EMPLOYMENT AND POSITIONS

Employment and Positions

1. Postdoctoral Position Working on Viral EpitranscriptomicsWhile it has been known for some time that both cellular and viral mRNAs are subject to post-transcriptional modifications that do not change their inherent coding capacity, the importance of these “epitranscriptomic” changes as regulators of gene expression has only recently come into focus. The most prevalent epitranscriptomic mark is addition of a methyl group to the N6 position of adenosine (m6A) and this modification is not only essential for embryonic viability and development in both plants and animals but also greatly influences viral replication, as documented, for example, in a recent publication from this laboratory (1) and discussed in more detail in a recent review from my group (2). The field of viral epitranscriptomics, while clearly important for understanding viral gene regulation, is nevertheless currently at a very early stage of development. As a result, this area of research offers a tremendous opportunity for a postdoc to contribute to an emerging but clearly important area of research that they eventually will be able to take with them when they start their own research group.

Candidates should be less than two years out from their Ph.D and should have documented expertise in the fields of virology and/or molecular biology.

1. Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, Cullen BR. (2016) Posttranscriptional m(6)A editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe; 19: 675-685. PMCID: PMC4867121.

2. Kennedy EM, Courtney DG, Tsai K & Cullen BR. (2017) Viral Epitranscriptomics. J Virol; 91. PMCID: PMC5391447.

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, gender expression, national origin, race, religion, sexual orientation, or veteran status.

Application Materials Required:

Submit the following items online at this website:

  • Cover Letter
  • Curriculum Vitae
  • Research Statement
  • Publication List
  • Contact information for 3 references
  • Three Reference Letters (to be submitted by the reference writers at this site help popup)
And anything else requested in the position description.

Further Info:

https://sites.duke.edu/cullenlaboratory/
email
919-684-3369
Duke University Medical Center, Box 3025
213 Research Dr., Room 0036 CARL Building
Durham, NC 27710
https://academicjobsonline.org/ajo/jobs/9170
    1. 2. Molecular Genetics of Vascular Malformations: A post-doctoral position is available to investigate the role of somatic mutation in vascular malformation syndromes. This newly funded study will investigate vascular malformations that have been proposed to follow a two-hit mutation mechanism, as previously described by our laboratory for Cerebral Cavernous Malformations (CCM). See Akers et al., 2009, Human Molecular Genetics 18:919-930, PMC26402099, and McDonald et al., 2014. Human Molecular Genetics 23:4357-70, PMC4103679 for our published studies on CCM. The anticipated start date is approximately September 1, 2017. The ideal applicant will have previous experience with library construction for next-generation DNA sequencing and with analysis of the sequence data. Please submit a cover letter outlining your professional interests, your CV, copies of up to three of your published papers, and the names and email addresses of three references. Please apply online at

https://academicjobsonline.org/ajo/jobs/9158

3. NIH funded post-doctoral position available in the Aballay lab at Duke University School of Medicine. Our laboratory has several exciting projects related to neural-immune communications, including the study of infection-induced neurodegeneration, the role of GPCRs in the control of immune homeostasis, and proteostasis. A variety of genetic, genomic, proteomic, pharmacologic, and cell biology approaches to clarify the role of the nervous system in the regulation of innate immune responses against bacterial pathogens will be used. The candidate should have a Ph.D. degree with a strong publication record. Applicants should submit a CV, a statement of no more than 2 pages of research interests and future career plans, and three letters of recommendation. Please apply at https://academicjobsonline.org/ajo/jobs/9096

4. An NIH-funded position is available for a highly motivated Postdoctoral Fellow to investigate Mycobacterium tuberculosis pathogenesis at the Department of Molecular Genetics and Microbiology, Duke University School of Medicine. The research will focus on: i) molecular mechanisms of infection-induced autophagy, and ii) the effects of autophagy on mycobacterial virulence and host immunity. The candidate will have the opportunity to expand knowledge in immunology, vaccinology, and in vivo animal models of M. tuberculosis infections. The successful candidate is expected to be knowledgeable of standard molecular, cellular biology, and immunology techniques. The applicant must hold a Ph.D. in Microbiology, Immunology, or related field. Candidates must have a record of publications as well as excellent communication (oral and written) skills. Ability to work independently is essential and previous research experience in the autophagy field and animal model is a plus.
Only candidates who have received their PhD or equivalent within the last 24 months will be considered. Qualified candidates meeting the above criteria should submit a current CV, description of previous research work, and the names and contact information of three references. Please apply at https://academicjobsonline.org/ajo/jobs/8808

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, gender expression, national origin, race, religion, sexual orientation, or veteran status.

Please visit Duke’s Human Resources website often for future openings or contact jason.howard@duke.edu for additional information.

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Duke University prohibits discrimination and harassment, and provides equal employment opportunity without regard to race, color, religion, national origin, disability, veteran status, sexual orientation, gender identity and expression, sex, age, or genetic information. Duke is committed to recruiting, hiring, and promoting qualified minorities, women, individuals with disabilities, and veterans.