Breast Cancer Cells Starve for Cystine. Ashley Chi, MD, PhD recently published a paper reporting that cells from a vicious and treatment-resistant form of breast cancer, called triple negative breast cancer (TNBC), die off rapidly when deprived of a key nutrient called cystine. Breast cancer is a collection of different types of cancer subtypes. Among different breast cancer subtypes, we don’t have effective treatment for triple negative breast cancer that lack any of the targets we use to target cancer cells. In this study, we have found that the triple negative breast cancer cannot live without the import of the cysteine, an non-essential amino acids. Therefore, the removal or blockage of cysteine import into cancer cells may help patients with triple negative breast cancer.The research was featured in Duke Today. Read the full article here.
The Minute Marvels, Computing the Structure of Smell. Claire de March, PhD was featured a 60 second video on the Duke Research Computing website. Claire studies how we detect smells and the molecular structures that accomplish the work of disclosing odors to our consciousness. Watch the video here.
Odom received the Emerging Leader Award. Audrey Odom John, MD, PhD, was awarded the emerging Leader Award from the Duke Medical Alumni Association at the Medical Alumni Reunion in November. Audrey also presented a seminar talk with the MGM Thursday Seminar Series on November 10, 2016. Watch Audrey’s video here.
Hu selected for a Graduate Fellowship in Neurosceinces sponsored by the Trice family. Xiaoyang Serene Hu is a graduate student in the department of Molecular Genetics & Microbiology. Her dissertation research focuses on receptor-ligand interactions underlying olfactory-mediated innate fear. Anxiety disorders affect nearly 18% of adults in the United States and a significant portion of them experience uncontrollable states of chronic fear-related anxiety. The etiology of the disorder is considered to be influenced by both innate and learned mechanisms of fear. The identification of receptors responsible for innate-fear behavior could be applied to future studies to examine how instinctive emotions are organized and regulated in the mammalian brain and help formulate modern emotion theories.
Genetic causes of small head size share common mechanism. Debby Silver, PhD was recently featured in Duke Today about a recent study of genetic microcephaly in mice that may reveal insights into Zika-based microcephaly. To read the full article on Duke Today click here. To read the published paper in PLOS Genetics, click here.
Can Scientists Really Harness the Poliovirus to Kill Cancer? Dr. Matthias Gromeier, MD was recently featured in DukeForward. Dr. Gromeier created a modified poliovirus that was awarded “breakthrough therapy” status from the Food and Drug Administration. The modified virus has shown dramatic success in a small number of adults with aggressive brain cancer. Dr. Gromeier was also featured on 60 minutes on CBS on March 29th, 2015. You may read the article here. Please visit CBSNews to watch the 60 minute video.
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