Vikas Yadav

Post-Doctoral Fellow
315 CARL Building
Box 3546, DUMC
Durham, NC 27710
Phone: 919.684.2809
Fax: 919.684.2790
vikas.yadav@duke.edu

Research Interest:

Research Interest: My research interest mainly lies in understand the genome dynamics and cell biology of the pathogenic Cryptococcus species including Cryptococcus neoformans, Cryptococcus deneoformans and Cryptococcus deuterogattii. My work involves understanding the role of retrotransposons in the genome organization of these pathogenic species and their possible role in the centromere and MAT locus evolution. I am also interested in Calcineurin signaling pathway that is essential for pathogenicity of Cryptococcus neoformans and some other fungi. Additionally, I also plan to develop some tools that can be used to study some critical cellular processes in this species.

Personal Interest:

I like hiking, photography, dancing and try to keep myself updated with latest gadgets.

Publications:

Yadav V, Sreekumar L, Guin K, Sanyal K. 2018. Five pillars of centromeric chromatin in fungal pathogens. PLoS pathog. (Pearls), 14(8): e1007150.

Yadav V#, Sanyal K#. 2018. Sad1 spatiotemporally regulates kinetochore clustering to ensure high-fidelity chromosome segregation in the human fungal pathogen Cryptococcus neoformans. mSphere. 3(4): e00190-18. #corresponding authors

Hoque J, Yadav V, Prakash RG, Sanyal K, Haldar J. 2018. Dual function polymer-silver nanocomposites for rapid killing of microbes and inhibiting biofilms. ACS Biomater. Sci. Eng. Article ASAP.

Yadav V
, Sun S, Billmyre RB, Thimmappa BC, Shea T, et al. 2018. RNAi is a critical determinant of centromere evolution in closely related fungi. Proc. Natl. Acad. Sci. 115(12):3108-3113.

Ghosh C, Yadav V, Younis W, Mohammad H, Hegazy YA, et al. 2017. Aryl-alkyl-lysines: membrane-active fungicides that act against biofilms of Candida albicans. ACS Infect. Dis. 3(4):293–301.

Sun S, Yadav V, Billmyre RB, Cuomo CA, Nowrousian M, et al. 2017. Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. PLoS Biol. 15(8): e2002527.

Datta A*, Yadav V*, Ghosh A, Choi J, Bhattacharyya D, et al. 2016. Mode of action of a designed antimicrobial peptide: high potency against Cryptococcus neoformans. Biophys. J. 111(8):1724–37. *equal authors

Hoque J, Adhikary U, Yadav V, Samaddar S, Konai MM, et al. 2016. Chitosan derivatives active against multidrug-resistant bacteria and pathogenic fungi: In vivo evaluation as topical antimicrobials. Mol. Pharm. 13(10):3578–89.

Hoque J, Akkapeddi P, Yadav V, Manjunath GB, Uppu DSSM, et al. 2015. Broad spectrum antibacterial and antifungal polymeric paint materials: Synthesis, structure-activity relationship, and membrane-active mode of action. ACS Appl. Mater. Interfaces. 7(3):1804–15.

Sutradhar S*, Yadav V*, Sridhar S*, Sreekumar L, Bhattacharyya D, et al. 2015. A comprehensive model to predict mitotic division in budding yeasts. Mol. Biol. Cell. 26(22):3954–65. *equal authors

Janbon G, Ormerod KL, Paulet D, Byrnes EJ, Yadav V, et al. 2014. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet. 10(4): e1004261.

Roy B, Varshney N, Yadav V, Sanyal K. 2013. The process of kinetochore assembly in yeasts. FEMS Microbiol. Lett. 338(2):107–17.

Kozubowski L*, Yadav V*, Chatterjee G, Sridhar S, Yamaguchi M, et al. 2013. Ordered kinetochore assembly in the human-pathogenic basidiomycetous yeast Cryptococcus neoformans. mBio. 4(5): e00614-13. *equal authors