Host-viral interactions, RNA-binding proteins, transcriptomics
I grew up in Ohio and received a BS in Biotechnology from Kent State University (2013). I then moved to Philadelphia, PA where I completed a PhD in biochemistry and molecular biophysics at the University of Pennsylvania in Kristen Lynch’s lab (2019). My doctoral work focused on alternative splicing regulation of both host and viral transcripts during influenza A infection. During my time in Kristen’s lab I became interested in the mechanisms that cause mis-regulation of RNA binding proteins during infection to give rise to changes in the host and viral transcriptomes. In Stacy’s lab I am exploring this interest by studying how the proteins that regulate post-transcriptional modification of RNA are functionally altered during infection with viruses from the Flaviviridae family.
Outside the lab, I am an avid Cleveland sports fan (including watching the Browns lose every week at local fan clubs). I also enjoy making music and playing video games.
Matthew G. Thompson, Kristen W. Lynch. Functional and mechanistic interplay of host and viral alternative splicing regulation during influenza infection. Cold Spring Harb Symp Quant Biol. (2020). Accepted.
Ke Zhang, Guijun Shang, Abhilash Padavannil, Juan Wang, Ramanavelan Sakthivel, Xiang Chen, Min Kim, Matthew G. Thompson, Adolfo García-Sastre, Kristen W. Lynch, Zhijian J. Chen, Yuh Min Chook, and Beatriz M. A. Fontoura. Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Natl. Acad. Sci. U. S. A. 115, E12218–E12227 (2018). Available from: https://www.pnas.org/content/115/52/E12218.long
Thompson, M. G., Raquel Muñoz-Moreno, Prasanna Bhat, Renat Roytenberg, John Lindberg, Matthew R Gazzara, Michael J Mallory, Ke Zhang, Adolfo García-Sastre, Beatriz MA Fontoura, Kristen W Lynch. Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing. Commun. 9, 2407 (2018). Available from: https://www.nature.com/articles/s41467-018-04779-4
Mor A, White A, Zhang K, Thompson M, Esparza M, Muñoz-Moreno R, Koide K, Lynch KW, García-Sastre A, Fontoura BMA. Influenza virus mRNA trafficking through host nuclear speckles. Nat Microbiol [Internet]. Nature Publishing Group; 2016 May 27 [cited 2016 Jul 7];1(7):16069. Available from: http://www.nature.com/articles/nmicrobiol201669 PMID: 27572970
Yarosh CA, Tapescu I, Thompson MG, Qiu J, Mallory MJ, Fu X-D, Lynch KW. TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells. Nucleic Acids Res [Internet]. 2015 Oct 15 [cited 2015 Nov 16];43(18):9006–16. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4605305&tool=pmcentrez&rendertype=abstract PMID: 26261210
Farhath MM, Thompson M, Ray S, Sewell A, Balci H, Basu S. G-Quadruplex-Enabling Sequence within the Human Tyrosine Hydroxylase Promoter Differentially Regulates Transcription. Biochemistry [Internet]. American Chemical Society; 2015 Sep 15 [cited 2015 Nov 18];54(36):5533–45. Available from: http://dx.doi.org/10.1021/acs.biochem.5b00209 PMID: 26284527