Kenneth Matt Scaglione, PhD – Biography

Research • Biography • Lab Members • Alumni • Publications

Matt has an undergraduate degree in Biology from McKendree University.  For his graduate work Matt attended Saint Louis University’s School of Medicine where he studied mechanisms that regulate ubiquitin transfer.  During his graduate studies Matt became interested in understanding protein homeostasis in neurodegenerative diseases and later joined Dr. Henry Paulson’s lab at the University of Michigan.  In Dr. Paulson’s lab Matt investigated mechanisms that regulate the neuroprotective E3 ligase CHIP and identified Ube2w as the first enzyme that mediates N-terminal ubiquitination.  Following his postdoctoral studies Matt joined the Department of Biochemistry at the Medical College of Wisconsin as an Assistant Professor.  At the Medical College of Wisconsin Matt became interested in how protein homeostasis in the social amoeba Dictyostelium discoideum and this became the main focus of his research.  In January of 2019 Matt moved to the Duke Center for Neurodegeneration and Neurotherapeutics at Duke University.  Matt is currently at Assistant Professor in the Department of Molecular Genetics and Microbiology with a secondary appointment in the Department of Neurology at Duke University.