Lee Dolat, PhD
Durham, NC 27710
Research Interest: I received my PhD from Drexel University and performed my thesis work in the lab of Dr. Elias Spiliotis. My research focused on the cell biology of septin GTPases, a family of heteropolymeric cytoskeletal-associated proteins, in the context of epithelial cell migration and macropinocytosis. In the Valdivia lab, I am interested in how Chlamydia trachomatis subverts host cellular pathways and the cytoskeleton during invasion and the formation of its replicative niche.
Lee Dolat and Elias T. Spiliotis (2016). Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion. The Journal of Cell Biology 214: 517 – 527.
Elias T. Spiliotis and Lee Dolat (2016). Priming for destruction: septins at the crossroads of mitochondrial fission and bacterial autophagy. EMBO Reports 17: 1-3.
Clayton Smith*, Lee Dolat*, Eva Forgacs, Elias T. Spiliotis and Vitold E. Galkin (2015). Septin 9 exhibits polymorphic binding to F-actin and inhibits myosin and cofilin activity. Journal of Molecular Biology 427: 3273 – 3284. *equal contribution
Lee Dolat, John L. Hunyara, Jonathan R. Bowen, Eva P. Karasmanis, Maha Elgawly, Vitold E. Galkin and Elias T. Spiliotis (2014). Septins promote stress fiber-mediated focal adhesion maturation and renal epithelial motility. The Journal of Cell Biology 207: 225 – 235.
Lee Dolat, Qicong Hu, Elias T. Spiliotis (2014). Septin functions in organ system physiology and pathology. Biological Chemistry 395:123 – 141.
Jianli Hu, Xiaobo Bai, Jonathan R. Bowen, Lee Dolat, Farida Korobova, Wenqian Yu, Peter W. Baas, Tatyana Svitkina, Gianluca Gallo, Elias T. Spiliotis (2012). Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons. Current Biology 22: 1109 – 1115.