Lee Dolat, PhD

Valdivia – Lab Members

Headshot of Lee Dolat, PhDPostdoctoral Fellow
272 Jones
DUMC
Durham, NC 27710
Phone: 919-668-2450
Fax: 919-684-2790
Email: lee.dolat@duke.edu

Research Interest: I received my PhD from Drexel University and performed my thesis work in the lab of Dr. Elias Spiliotis. My research focused on the cell biology of septin GTPases, a family of heteropolymeric cytoskeletal-associated proteins, in the context of epithelial cell migration and macropinocytosis. In the Valdivia lab, I am interested in how Chlamydia trachomatis subverts host cellular pathways and the cytoskeleton during invasion and the formation of its replicative niche.

Publications List:

Lee Dolat and Elias T. Spiliotis (2016). Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion. The Journal of Cell Biology 214: 517 – 527.

Elias T. Spiliotis and Lee Dolat (2016). Priming for destruction: septins at the crossroads of mitochondrial fission and bacterial autophagy. EMBO Reports 17: 1-3.

Clayton Smith*, Lee Dolat*, Eva Forgacs, Elias T. Spiliotis and Vitold E. Galkin (2015). Septin 9 exhibits polymorphic binding to F-actin and inhibits myosin and cofilin activity. Journal of Molecular Biology 427: 3273 – 3284.  *equal contribution

Lee Dolat, John L. Hunyara, Jonathan R. Bowen, Eva P. Karasmanis, Maha Elgawly, Vitold E. Galkin and Elias T. Spiliotis (2014). Septins promote stress fiber-mediated focal adhesion maturation and renal epithelial motility. The Journal of Cell Biology 207: 225 – 235.

Lee Dolat, Qicong Hu, Elias T. Spiliotis (2014). Septin functions in organ system physiology and pathology. Biological Chemistry 395:123 – 141.

Jianli Hu, Xiaobo Bai, Jonathan R. Bowen, Lee Dolat, Farida Korobova, Wenqian Yu, Peter W. Baas, Tatyana Svitkina, Gianluca Gallo, Elias T. Spiliotis (2012). Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons. Current Biology 22: 1109 – 1115.