Research Assistant Professor
218 CARL Building
Durham, NC 27710
Phone: (919) 684-1375
Fax: (919) 684-2790
I received my PhD from the University of Chicago where I studied toxin/antitoxin systems in Brucella abortus. I then did my post-doctoral training at Memorial Sloan-Kettering and studied DNA repair in Mycobacterium tuberculosis. I have now jumped ship to become a virologist and my project focuses on understanding the mechanisms by which influenza viruses cause disease.
My interests outside of lab include knitting and finding new bakeries and restaurants to try.
Wipperman MF*, Heaton BE*, Nautiyal A*, Adefisayo O*, Evans H, Gupta R, van Ditmarsch D, Soni R, Hendrickson R, Johnson J, Krogan N, Glickman MS. Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin- Mediated Inhibition of the RecA Coprotease. Molecular Cell. 2018 *Authors contributed equally
Heaton BE, Kennedy EM, Dumm RE, Harding AT, Sacco MT, Sachs D, Heaton NS. A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. Cell Reports. 2017 20(7): p1503-1512. http://dx.doi.org/10.1016/j.celrep.2017.07.060 PMID: 28813663
Harding AT, Heaton BE, Dumm RE, Heaton NS. Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs. mBio. 2017 June 6, Vol. 8 no.3 e00669-17 doi: 10.1128/mBio.00669-17 PMID: 28588131
Heaton BE, Barkan D, Bongiorno P, Karakousis PC, Glickman MS. “Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection” 2014. Infection and Immunity. 82(8):3177-85. PMCID: PMC4136208
Heaton BE, Herrou J, Blackwell A, Wysocki V, and Crosson S. “Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus” 2012. Journal of Biological Chemistry. 287:12098-12110. PMCID: PMC3320955
Ragle BE, Karginov VA, and Bubeck Wardenburg J. “Prevention and treatment of Staphylococcus aureus pneumonia with a beta-cyclodextrin derivative. 2010. Antimicrobial Agents and Chemotherapy. 54(1):298-304. PMCID: PMC2798498
Ragle BE, Bubeck Wardenburg J. “Anti-α-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia.” 2009. Infection and Immunity. 77(7):2712-8. PMCID: PMC2708543
Dos Santos PC, Johnson DC, Ragle BE, Unciuleac MC, Dean DR. “Controlled expression of nif and isc iron-sulfur protein maturation components reveals target specificity and limited functional replacement between the two systems.” 2007. J Bacteriol. 189(7):2854-62. PMCID: PMC1855825