Brook Heaton

Heaton – Lab Members

Headshot of Brook Heaton_Heaton LabResearch Assistant Professor
218 CARL Building
Box 3054
Durham, NC 27710
Phone: (919) 684-1375
Fax: (919) 684-2790
brook.heaton@dm.duke.edu

Research Interest:

I received my PhD from the University of Chicago where I studied toxin/antitoxin systems in Brucella abortus. I then did my post-doctoral training at Memorial Sloan-Kettering and studied DNA repair in Mycobacterium tuberculosis.   I have now jumped ship to become a virologist and my project focuses on understanding the mechanisms by which influenza viruses cause disease.

Personal Interests:

My interests outside of lab include knitting and finding new bakeries and restaurants to try.

Publications List:

Wipperman MF*, Heaton BE*, Nautiyal A*, Adefisayo O*, Evans H, Gupta R, van Ditmarsch D, Soni R, Hendrickson R, Johnson J, Krogan N, Glickman MS. Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin- Mediated Inhibition of the RecA Coprotease. Molecular Cell. 2018 *Authors contributed equally

Heaton BE, Kennedy EM, Dumm RE, Harding AT, Sacco MT, Sachs D, Heaton NS. A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. Cell Reports. 2017 20(7): p1503-1512. http://dx.doi.org/10.1016/j.celrep.2017.07.060 PMID: 28813663

Harding AT, Heaton BE, Dumm RE, Heaton NS. Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs. mBio. 2017 June 6, Vol. 8 no.3 e00669-17 doi: 10.1128/mBio.00669-17 PMID: 28588131

Heaton BE, Barkan D, Bongiorno P, Karakousis PC, Glickman MS. “Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection” 2014. Infection and Immunity. 82(8):3177-85. PMCID: PMC4136208

Heaton BE, Herrou J, Blackwell A, Wysocki V, and Crosson S. “Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus” 2012. Journal of Biological Chemistry. 287:12098-12110. PMCID: PMC3320955

Ragle BE, Karginov VA, and Bubeck Wardenburg J. “Prevention and treatment of Staphylococcus aureus pneumonia with a beta-cyclodextrin derivative. 2010. Antimicrobial Agents and Chemotherapy. 54(1):298-304. PMCID: PMC2798498

Ragle BE, Bubeck Wardenburg J. “Anti-α-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia.” 2009. Infection and Immunity. 77(7):2712-8. PMCID: PMC2708543

Dos Santos PC, Johnson DC, Ragle BE, Unciuleac MC, Dean DR. “Controlled expression of nif and isc iron-sulfur protein maturation components reveals target specificity and limited functional replacement between the two systems.” 2007.  J Bacteriol.  189(7):2854-62. PMCID: PMC1855825