Miriam Kutsch, PhD
230 Jones Building
Durham, NC 27710
I studied Biochemistry at the Ruhr-University Bochum (RUB) in Germany. By joining the group of Christian Herrmann I had the opportunity to gain experience in purifying recombinant proteins and characterizing them with biochemical and biophysical techniques. In particular, I investigated members of the human guanylate-binding protein (hGBP) family which belong to the large GTPases. GBPs play important roles in the innate immune response against viral and bacterial pathogens. In order to move from investigating the molecular basis to investigate the biological functions of hGBPs I joint the group of Jörn Coers at Duke after earning my Doctor of Natural Sciences in Chemistry. My goal is to identify molecular mechanisms of antibacterial effects mediated by hGBPs using a combination of in vitro and in cellula techniques.
I love to travel.
- Kutsch M, Ince S & Herrmann C (2018) Homo and hetero dimerisation of the human guanylate-binding proteins hGBP-1 and hGBP-5 characterised by affinities and kinetics. FEBS J 285, 2019–2036. doi:10.1111/febs.14459
- Ince S*, Kutsch M*, Shydlovskyi S & Herrmann C (2017) The human guanylate-binding proteins hGBP-1 and hGBP-5 cycle between monomers and dimers only. FEBS J 284, 2284–2301. doi: 10.1111/febs.14126
- Shydlovskyi S, Zienert AY, Ince S, Dovengerds C, Hohendahl A, Dargazanli JM, Blum A, Günther SD, Kladt N, Stürzl M, Schauss A, Kutsch M, Roux A, Praefcke GJK. & Herrmann C (2017) Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1. Proc Natl Acad Sci 114, E5559–E5568. doi: 10.1073/pnas.1620959114
- Athanasopoulos PS, Jacob W, Neumann S, Kutsch M, Wolters D, Tan EK, Bichler Z, Herrmann C & Heumann R (2016) Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2. Biological Chemistry 397, 6. doi: 10.1515/hsz-2015-0189
- Kutsch M, Hortmann P, Herrmann C, Weibels S & Weingärtner H (2016) Dissecting ion-specific from electrostatic salt effects on amyloid fibrillation: A case study of insulin. Biointerphases 11, 019008. doi: 10.1116/1.4941008