Exploring the link between microbial pathogenesis and gene regulation/expression in response to environmental stress. I am currently studying temperature-dependent mutagenesis and the movement of transposons in the fungal pathogen Cryptococcus neoformans to determine whether transposition in C. neoformans occurs during host-pathogen interactions.
I enjoy cooking and entertaining with friends and family, enjoying all of the amazing food offerings in the area.
Gusa, A., Williams, J.D., Cho, J., Averette, A.F., Sun, S., Shouse, E., Heitman, J., Alspaugh, J.A., Jinks-Robertson, S. Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro. Proceedings of the National Academy of Sciences 2020, 117 (18) 9973-9980; https://doi.org/10.1073/pnas.2001451117
Gusa, A., Jinks-Robertson, S., Mitotic Recombination and Adaptive Genomic Changes in Human Pathogenic Fungi. Genes 2019, 10(11), 901; https://doi.org/10.3390/genes10110901
Balthazar J.T., Gusa A., Martin L.E., Choudhury B., Carlson R., Shafer W.M. 2011. Lipooligosaccharide structure is an important determinant in the resistance of Neisseria gonorrhoeae to antimicrobial agents of innate host defense. Front Microbiol, 2(30).
Gusa, A., Froehlich, B.J., Desai, D., Stringer, V. and J.R. Scott. 2007. CovR activation of the dipeptide permease promoter (PdppA) in group A streptococcus. J Bacteriol, 189(4):1407-16.
Gusa, A., Gao, J., Stringer, V., Churchward, G., and J.R. Scott. 2006. Phosphorylation of the group A streptococcal CovR response regulator causes dimerization and promoter-specific recruitment of RNA polymerase. J Bacteriol, 188(13):4620-6.
Gao, J., Gusa, A., Scott, J.R., and G. Churchward. 2005. Binding of the global response regulator protein CovR to the sag promoter of Streptococcus pyogenes reveals a new mode of CovR-DNA interaction. J Biol Chem, 280(47):38948-56.
Gusa, A. and J.R. Scott. 2005. The CovR response regulator of group A streptococcus (GAS) acts directly to repress its own promoter. Mol Microbiol, 56(5):1195-1207.
Bjoersdorff, A., Bagert, B., Massung, R.F., Gusa, A., and I. Eliasson. 2002. Isolation and characterization of two European strains of Ehrlichia phagocytophila of equine origin. Clin Diagn Lab Immunol, 9(2):341-343.
Massung, R.F., Lee, K., Mauel, M., and A. Gusa. 2002. Characterization of the rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila. DNA Cell Biol, 21(8):587-596
Gusa, A., R.S. Buller, G.A. Storch, M.M. Huyke, L.J. Machado, L.N. Slater, S.L. Stockham, and R.F. Massung. 2001. Identification of a p28 gene in Ehrlichia ewingii: evaluation of gene for use as a target for a species-specific PCR diagnostic assay. J Clin Microbiol, 39(11):3871-3876