Jamie Scaglione

Scaglione – Lab Members

Jamie Scaglione ThumbnailResearch Scientist
MSRBIII Room 5200
Durham, NC 27710
Phone: 919-613-5957


Research Interests:
protein quality control, protein structure/function

Personal Interestes:
I enjoy reading, knitting, sewing and spending time with family.


S. Santarriaga, A. Fikejs, J.B. Scaglione, K.M. Scaglione “A Heat Shock Protein 48 (HSP48) Biomolecular Condensate Is Induced During Dictyostelium discoideum Development” mSphere 4 314-19 (2019).

S. Santarriaga, A. Petersen, K. Ndukwe, A. Brandt, N. Gerges, J.B. Scaglione, K.M. Scaglione “The Social Amoeba Dictyostelium discoideum is Highly Resistant to Polyglutamine Aggregation” Journal of Biological Chemistry 290 25571-8  (2015).

S.J. Wood, Y.A. Park, N.P. Kanneganti, H. R. Mukkisa, L.L. Crisman, S.E. Davis, J.L. Vandenbosch, J.B. Scaglione, D.L. Heyl “Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity” International Journal of Peptide Research and Therapeutics, 20  519-530 (2014).

 A. Tripathi, M.M. Schofield, G.E. Chlipala, P.J. Schultz, I. Yim, S.A. Newmister, T.D. Nusca, J.B. Scaglione, P.C. Hanna, G. Tamayo-Castillo, D.H. Sherman “Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis” Journal of the American Chemical Society, 136 1579-86 (2014).

Nusca, Y. Kim, N. Maltseva, J. Lee, W. Eschenfeldt, L. Stols, M. Schofield, J. B. Scaglione, S. Dixon, D. Oves-Costales, G. Challis, P. Hanna, B. Pfleger, A. Joachimiak, D.H. Sherman “Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis.” Journal of Biological Chemistry 287, 16058-16072 (2012).

 D. H. Sherman, C. M. Rath, J. Mortison, J. B. Scaglione, J. D. Kittendorf, “Biosynthetic principles in marine natural product systems”; Chapter in Handbook of Marine Natural Products. (eds) E. Fattorusso, O. Taglialatela-Scafati, and W.H. Gerwick. Springer Science (2012).

J. B. Scaglione, D. Akey, R. Sullivan, J. Kittendorf, C. Rath, E-S. Kim, J. Smith, D. H. Sherman “Biochemical and Structural Characterization of the Tautomycetin Thioesterase:  Analysis of a Stereoselective Polyketide Hydrolase.” Angewandte Chemie 49, 5726-5730 (2010).

C. Rath, J. B. Scaglione, J. Kittendorf, D. H. Sherman “Hybrid PKS/NRPS natural product biosynthesis” (Chapter). In Comprehensive Natural Products II: Chemistry and Biology; Lew Mander, Hung-Wend Liu Editors; Elsevier: Oxford 2010; volume 1: 453-492.

B. F. Pfleger, Y. Kim, T. D. Nusca, N. Maltseva, J. Y. Lee, C. M. Rath, J. B. Scaglione, B. K. Janes, E. C. Anderson, N. H. Bergman, P. C. Hanna, A.  Joachimiak, D. H. Sherman “Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.”   Proceedings of the National Academy of Sciences of the United States of America 105, 17133-17138 (2008).

J. B. Scaglione*, I. Jastrzebska*, K. Krishnan, P. Li, G. Akk, B. D. Manion, A. Benz, A. Taylor, N. P. Rath, A.S. Evers, C. F. Zorumski, S. Mennerick, Douglas F. Covey  “Neurosteroid Analogues. 14. Alternative Ring System Scaffolds: GABA Modulatory and Anesthetic Actions of Cyclopenta[b]phenanthrenes and Cyclopenta[b]anthracenes” Journal of Medicinal Chemistry 51, 1309-1318 (2008).
*co-first author

I. Jastrzebska*, J. B. Scaglione*, G. T. DeKoster, N. P. Rath, D. F. Covey  “Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems” Journal of Organic Chemistry 72, 4837-4843 (2007).
*co-first author

  J. B. Scaglione, B. D. Manion, A. Benz, A. Taylor, G. T. DeKoster, N. P. Rath, A. S. Evers, C. F. Zorumski, S. Mennerick, D. F. Covey  “Neurosteroid Analogues. 11. Alternative Ring System Scaffolds: g-Aminobutyric Acid Receptor Modulation and Anesthetic Actions of Benz[f]indenes” Journal of Medicinal Chemistry 49, 4595-4605 (2006).

J. B. Scaglione, N. P. Rath, D. F. CoveyFirst synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes” Journal of Organic Chemistry 70, 1089-1092 (2005).

G. P. Tochtrop, J. L. Bruns, C. Tang, D. F. Covey, D. P. Cistola “Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein” Biochemistry 42, 11561-11567 (2003).