A Model for Coordinated Posttranscriptional Gene Control

DURHAM, N.C. – Duke scientists have developed a model for coordinated gene control through the action of RNA binding proteins that regulate classes of mRNAs during cell growth and development.

The model predicts that functionally related groups of mRNAs are coordinately regulated at the posttranscriptional level by specific mRNA binding proteins that recognize common sequences in the mRNAs The modes, authored by Jack Keene and Scott Tenenbaum in the Department of Molecular Genetics and Microbiology at Duke, is described in a paper published in the June 2002 issue of Molecular Cell.