Second Annual Joklik Distinguished Lectureship

Durham, N.C. —The Department of Molecular Genetics and Microbiology will host the Second Annual Joklik Distinguished Lecture on September 23, 2011 in conjunction with the annual MGM departmental retreat. This year’s speaker is Karla Kirkegaard, PhD, Professor and Chair of the Department of Microbiology and Immunology at the Stanford University School of Medicine.

Karla Kirkegaard, PhD
Professor and Chair
Department of Microbiology and Immunology
Stanford University School of Medicine
Fairchild D325
299 Campus Drive
Stanford CA 94305-5124
karlak@stanford.edu

Seminar: Positive-strand RNA viruses: Dominant drug targets and novel routes of viral spread
4:00pm-5:00pm
103 Bryan Research Building
Reception to follow lecture

Karla Kirkegaard, PhD is Professor and Chair of the Department of Microbiology and Immunology at Stanford University School of Medicine. Her laboratory studies the biochemistry, cell biology, and genetics of RNA viral propagation.

The laboratory’s recent work has emphasized studies of the mechanism of the poliovirus RNA-dependent RNA polymerase and its cooperative interaction with template RNAs, as well as the inhibition of protein secretion and evasion of the cellular immune response by non-enveloped RNA viruses.

Dr. Kirkegaard has received a number of awards including the Searle Scholar’s Award, a David and Lucile Packard Fellowship, an American Cancer Society Junior Faculty Research Award, and an appointment as an Ellison Senior Scholar in Global Infectious Disease.  In 2006, she was awarded a prestigious National Institutes of Health (NIH) Director’s Pioneer Award, which will support her investigation of how the dengue, West Nile, hepatitis C, and polio viruses develop drug resistance and how to reduce the frequency of such occurrences.

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The Joklik Distinguished Lectureship honors and commemorates the myriad contributions of Dr. Bill (Wolfgang Karl) Joklik to the Department of Microbiology and Immunology at Duke, which he chaired; to the institution, specifically for his role as the co-founder of the Duke Comprehensive Cancer Center; and to the broader microbiology community for his research program in virology, service in founding the American Society for Virology, and for his editorial work for the journal Virology and the seminal text, Zinsser’s Microbiology.

Together with the Nobel Laureate Paul Berg, Dr. Joklik was responsible for the discovery of the enzyme terminal transferase. Dr. Joklik was the first to examine the mechanism of action of interferon–the first cytokine to be recognized in molecular terms in 1964–and was recently conferred an honorary member of the International Society for Interferon and Cytokine Research. Much of his scientific career was devoted to the development and application of molecular virology with a focus on reovirus and vaccinia. Many alumni who trained in his laboratory are leading investigators in biomedical research, including Joseph Nevins, PhD, who is the Barbara Levine University Professor of Breast Cancer Genomics.

Dr. Joklik is currently a James B. Duke Professor Emeritus of Molecular Genetics and Microbiology, a member of the National Academy of Sciences, and an active member of the community.