Genetics of vertebrates/mammals

 

Headshot of Matt Detter

Matt Detter
Marchuk Lab

 

 

 

 

 

 

We work with genetically engineered mice to recapitulate a human neurovascular disease called cerebral cavernous malformations. By developing these mouse models we hope to gain a fundamental understanding of how this disease develops and test the efficacy of proposed therapeutics.

 

mouse-brain

Above is an image of a mouse brain which demonstrates the characteristic dilatation of blood vessels observed in the human disease.

endothelial cells

Fluorescent marking of the endothelial cells with the brain vasculature: