Genetics of vertebrates/mammals


Headshot of Matt Detter

Matt Detter
Marchuk Lab







We work with genetically engineered mice to recapitulate a human neurovascular disease called cerebral cavernous malformations. By developing these mouse models we hope to gain a fundamental understanding of how this disease develops and test the efficacy of proposed therapeutics.



Above is an image of a mouse brain which demonstrates the characteristic dilatation of blood vessels observed in the human disease.

endothelial cells

Fluorescent marking of the endothelial cells with the brain vasculature: