Genetics of vertebrates/mammals
Matt Detter
Marchuk Lab
We work with genetically engineered mice to recapitulate a human neurovascular disease called cerebral cavernous malformations. By developing these mouse models we hope to gain a fundamental understanding of how this disease develops and test the efficacy of proposed therapeutics.
Above is an image of a mouse brain which demonstrates the characteristic dilatation of blood vessels observed in the human disease.
Fluorescent marking of the endothelial cells with the brain vasculature: