Riley Mangan

CMB/MGM Graduate Student (2018)
Lowe Lab
289 CARL, 3175 DUMC
Durham, NC 27710
Fax: 919-684-2790


Research Interest: My primary research interest is in human brain evolution. My work combines techniques from comparative genomics, computational molecular evolution, and developmental neuroscience to investigate how the neurodevelopmental gene regulatory architecture has changed in the human evolutionary lineage to give rise to the human-specific phenotypes of enhanced cognition, neocortical expansion, and language.

Personal Interests: Outside the lab, I enjoy performing as a freelance jazz pianist in the Raleigh-Durham area.

Publications List:

Martinez DR, Kumar A, Tu JJ, Mangold JF, Mangan RJ, Goswami R, Giorgi EE, Chen J, Mengual M, Douglas AO, Heimsath H, Saunders KO, Eudailey J, Hernandez G, PK Morgan-Asiedu, Wiehe K, LaBranche C, Montefiori DC, Gao F, Permar SR. (2019) Maternal broadly neutralizing responses select for neutralization-resistant infant transmitted/founder HIV variants. Preprint:

Nelson AN, Goswami R, Dennis M, Tu J, Mangan RJ, Saha P, Cain DW, Shen X, Bar K, Hudgens M, Pollara J, De Paris K, Van Rompay KKA, and Permar SR. (2019) SHIV CH505 infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T follicular helper (Tfh) and germinal center B cell landscapes. Accepted, Journal of Virology.

Mangan RJ, Stamper L, Ohashi T, Eudailey JA, Go EP, Jeager F, Itell HL, Watts BE, Fouda GG, Erickson HP, Alam SM, Desaire H, Permar SR. (2019) Determinants of tenascin-C and HIV Env binding and neutralization. Mucosal Immunology.

Kim J*, Chun A*, Mangan RJ, Doyle H, Mourao B, and El Bejjani R. (2019) A retromer-independent function for RAB-6.2/RAB6 in C. elegans epidermis integrity. Journal of Cell Science. 8(3): 3826-2839. *Indicates co-first author

Himes JE, Goswami R*, Mangan RJ*, Kumar A, Jeffries TL, Eudailey JA, Hemsath H, Nguyen QN, Pollara J, LaBranche C, Chen M, Vandergrift NA, Schiro F, Midkiff C, Ferrari G, Montefiori DC, Alvarez-Hernandez X, Aye PP, Permar SR. (2018) Polyclonal anti-HIV envelope breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys. Mucosal Immunology. 11(6): 1716-1726. *Indicates co-second author

Nguyen QN, Martinez DR, Himes JE, Edwards RW, Han Q, Kumar A, Mangan R, Nicely NI, Shen X, Pollara J, Permar SR. (2018) Predominant envelope variable loop 2-specific and antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys. Retrovirology 15(1): 24.

Principe DR, Diaz AM, Torres C, Mangan RJ, DeCant B, McKinney R, Tsao MS, Lowy A, Munshi HG, Grippo PJ (2017) TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. Oncogene 36(30):4336-4348.

Principe DR, Mangan RJ, Grippo PJ. (2017) Transforming Growth Factor β. Cancer Therapeutic Targets, pp.503-516. (Textbook Chapter)

Principe DR, DeCant B, Staudacher J, Vitello D, Mangan RJ, Wayne E, Mascariñas E, Diaz AM, Bauer J, McKinney RD, Khazaie K, Pasche B, Dawson DW, Munshi HG, Grippo PJ, Jung B (2016) Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation. Oncotarget 8(3):3826-3839.

Principe DR, Decant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F (2016) PEDF inhibits pancreatic tumorigenesis by attenuating the fibroinflammatory reaction. Oncotarget 7(19): 28218-28234.