Research Interest: My general research interests include protein quality control and post-translational modifications. I am working in the lab of Dr. Matt Scaglione. I work on a ubiquitin-conjugating enzyme (E2), the Ube2k. I am especially interested in investigating a) the structural-functional mechanisms underlying the K48-linked polyubiquitin chain synthesis by Ube2k. And b) the mechanisms on the regulatory roles of Ube2k in pathogenic Huntingtin protein quality control.
Personal Interests: Going for walks and watching squirrels.
Jie Tang, Santhanakrishanan Srinivasan, Wenmin Yuan, Ran Ming, Yayuan Liu, Zhipeng Dai, Charles O. Noble, Mark E. Hayes, Nan Zheng, Wenlei Jiang, Francis C. Szoka, Anna Schwendeman. (2018). Development of a flow-through USP4 apparatus drug release assay for the evaluation of amphotericin B liposome. European Journal of Pharmaceutics and Biopharmaceutics.
Dan Li, Maria V. Fawaz, Emily Morin, Ran Ming, Denis Sviridov, Jie Tang, Rose Ackerman, Karl Olsen, Alan Remaley, Anna Schwendeman. (2017). The effect of synthetic high density lipoproteins modification with polyethylene glycol on pharmacokinetics and pharmacodynamics. Molecular Pharmaceutics.