Thomas G. Mitchell, PhD – Publications

Faculty and Research

Thomas G. Mitchell, PhD
Associate Professor Emeritus

researchbiography • publications

Representative Publications:

Mitchell TG. 2019. Medical Mycology. In: Riedel S, Morse SA, Mietzner TA, Miller S (eds). Jawetz, Melnick & Adelberg’s Medical Microbiology. McGraw-Hill Education, New York, NY, In Press.

Chen Y, Farrer RA, Giamberardino C, Sakthikumar S, Jones A, Yang T, Tenor JL, Wagih O, Van WM, Govender NP, Mitchell TG, Litvintseva AP, Cuomo CA, Perfect JR. 2017. Microevolution of serial clinical isolates of Cryptococcus neoformans var. grubii and C. gattii. mBio 8:e00166-17. doi: 10.1128/mBio.00166-17. https://mbio.asm.org/content/8/2/e00166-17.

Chen Y, Litvintseva AP, Frazzitta AE, Haverkamp MR, Wang L, Fang C, Muthoga C, Mitchell TG, Perfect JR. 2015. Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana. Molecular Ecology 24:3559-3571. doi: 10.1111/mec.13260. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758399/.

van Wyk M, Govender NP, Mitchell TG, Litvintseva AP, GERMS-SA. 2014. Multilocus sequence typing of serially collected isolates of Cryptococcus from HIV-infected patients in South Africa. Journal of Clinical Microbiology 52:1921-1931. doi: 0.1128/JCM.03177-13. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042789/.

Litvintseva AP and Mitchell TG. 2012. Population genetic analyses reveal the African origin and strain variation of Cryptococcus neoformans var. grubii. PLoS Pathogens 8:e1002495. doi: 10.1371/journal.ppat.1002495. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285590/.

Schell WA, Benton JL, Smith PB, Poore M, Rouse JL, Boles DJ, Johnson MD, Alexander BD, Pamula VK, Eckhardt AE, Pollack MG, Benjamin DK, Jr., Perfect JR, Mitchell TG. 2012. Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood. European Journal of Clinical Microbiology and Infectious Diseases 31:2237-2245. doi: 10.1007/s10096-012-1561-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939829/.

Litvintseva AP, Carbone I, Rossouw J, Thakur R, Govender NP, Mitchell TG. 2011. Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa. PLoS ONE 6:e19688. doi: 10.1371/journal.pone.0019688. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092753/.

Litvintseva AP, Xu J, Mitchell TG. 2011. Population structure and ecology of Cryptococcus neoformans and Cryptococcus gattii. In: Heitman J, Kozel TR, Kwon-Chung KJ, Perfect JR, Casadevall A (eds). Cryptococcus: from Human Pathogen to Model Yeast. ASM Press, Washington, DC. pp 97-111. ISBN: 9781555815011. doi: 10.1128/9781555816858.ch8. http://www.asmscience.org/content/book/10.1128/9781555816858.ch08.

Mitchell TG, Castañeda E, Nielsen K, Wanke B, Lazéra MS. 2011. Environmental niches of Cryptococcus neoformans and Cryptococcus gattii. In: Heitman J, Kozel TR, Kwon-Chung KJ, Perfect JR, Casadevall A (eds). Cryptococcus: From Human Pathogen to Model Yeast. ASM Press, Washington, DC. pp 237-259. ISBN: 9781555815011. doi: 10.1128/9781555816858.ch18. http://www.asmscience.org/content/book/10.1128/9781555816858.ch18.

Govender NP, Mitchell TG, Litvintseva AP, Miglia KJ. 2011. Cryptococcosis in Africa. In: Heitman J, Kozel TR, Kwon-Chung KJ, Perfect JR, Casadevall A (eds). Cryptococcus: from Human Pathogen to Model Yeast. ASM Press, Washington, DC. pp 269-285. ISBN: 9781555815011. Doi: 10.1128/9781555816858.ch20. http://www.asmscience.org/content/book/10.1128/9781555816858.ch20.

Miglia KJ, Govender NP, Rossouw J, Meiring ST, Mitchell TG. 2011. Analysis of pediatric isolates of Cryptococcus neoformans from South Africa. Journal of Clinical Microbiology 49:307-314. doi: 10.1128/JCM.01277-10. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020432/.

Mitchell TG, Verweij PE, Hoepelman AIM. 2010. Opportunistic and systemic fungi. In: Cohen J, Powderly WG, Opal SM (eds). Infectious Diseases. Mosby Elsevier, London. pp 1823-1852.

Wulff-Burchfield E, Schell WA, Eckhardt AE, Pollack MG, Hua Z, Rouse JL, Pamula VK, Srinivasan V, Benton JL, Alexander BD, Wilfret DA, Kraft M, Cairns CB, Perfect JR, Mitchell TG. 2010. Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens. Diagnostic Microbiology and Infectious Disease 67:22-29. doi: 10.1016/j.diagmicrobio.2009.12.020. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854258/.

Litvintseva AP and Mitchell TG. 2009. Most environmental isolates of Cryptococcus neoformans var. grubii are not lethal for mice. Infection and Immunity 77:3188-3195. doi: 10.1128/IAI.00296-09. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715664/.

Litvintseva AP, Thakur R, Vilgalys RJ, Mitchell TG. 2006. Multilocus sequence typing reveals three genetic subpopulations of Cryptococcus neoformans var. grubii (serotype A), including a unique population in Botswana. Genetics 172:2223-2238. doi: 10.1534/genetics.105.046672. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456387/.

Mitchell TG. 2005. Kingdom fungi: fungal phylogeny and systematics. In: Merz WG, Hay RJ (eds). Topley & Wilson’s Microbiology & Microbial Infections. Medical Mycology. Hodder Arnold, London. pp 43-68.

Xu J, Vilgalys RJ, Mitchell TG. 2000. Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans. Molecular Ecology 9:1471-1481. doi: 10.1046/j.1365-294x.2000.01021.x. http://www.ncbi.nlm.nih.gov/pubmed/11050543.

Xu J, Vilgalys RJ, Mitchell TG. 1999. Lack of genetic differentiation between two geographically diverse samples of Candida albicans isolated from patients infected with human immunodeficiency virus. Journal of Bacteriology 181:1369-1373. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC93522/

Gräser Y, Volovsek M, Arrington J, Schönian G, Presber W, Mitchell TG, Vilgalys RJ. 1996. Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination. Proceedings of the National Academy of Science, USA 93:12473-12477. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC38016/.

Mitchell TG and Perfect JR. 1995. Cryptococcosis in the era of AIDS—100 years after the discovery of Cryptococcus neoformans. Clinical Microbiology Reviews 8:515-548. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC172874/.

Miller MF and Mitchell TG. 1991. Killing of Cryptococcus neoformans strains by human neutrophils and monocytes. Infection and Immunity 59:24-28. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC257700/.

Small JM and Mitchell TG. 1989. Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A. Infection and Immunity 57:3751-3756. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC259900/.