Sue Jinks-Robertson, PhD – Publications

Mary Bernheim Distinguished Professor and co-Vice Chair
Director, Cell and Molecular Biology Program

researchbiography • lab members • publications • lab website

Representative Publications:

Sloan R, Huang SN, Pommier Y, Jinks-Robertson S.Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae. DNA Repair (Amst). 2017 Nov;59:69-75. doi: 10.1016/j.dnarep.2017.09.004. Epub 2017 Sep 18.

Guo X, Hum YF, Lehner K, Jinks-Robertson S.Regulation of hetDNA Length during Mitotic Double-Strand Break Repair in Yeast. Mol Cell. 2017 Aug 17;67(4):539-549.e4. doi: 10.1016/j.molcel.2017.07.009. Epub 2017 Aug 3. PMID:

Hum YF, Jinks-Robertson S.Mitotic Gene Conversion Tracts Associated with Repair of a Defined Double-Strand Break in Saccharomyces cerevisiae. Genetics. 2017 Sep;207(1):115-128. doi: 10.1534/genetics.117.300057. Epub 2017 Jul 25. PMID:

Kim N, Jinks-Robertson S.The Top1 paradox: Friend and foe of the eukaryotic genome.
DNA Repair (Amst). 2017 Aug;56:33-41. doi: 10.1016/j.dnarep.2017.06.005. Epub 2017 Jun 9. Review.
PMID:

Cho JE, Jinks-Robertson S.Ribonucleotides and Transcription-Associated Mutagenesis in Yeast.
J Mol Biol. 2017 Oct 27;429(21):3156-3167. doi: 10.1016/j.jmb.2016.08.005. Epub 2016 Aug 7. Review. PMID:

Cho, J.E., Huang, S.N., Burgers, P.M., Shuman, S., Pommier. Y.and Jinks-Robertson S. (2016). Parallel analysis of ribonucleotide-dependent deletions produced by yast Top1 in vitro and in vivo. Nucleic Acids Res. 44, 7714-7721.

Andersen, S.L., Sloan, R., Petes, T.D. and Jinks-Robertson, S. (2015). Genome-destabilizing effects associated with Top1 loss or accumulation of Top1 cleavage complexes in yeast. PLoS Genet. 11, e1005098.

Guo X., Lehner, K., O’Connell, K., Zhang, J., Dave, S.S. and Jinks-Robertson, S. (2015). SMRT sequencing for parallel analysis of multiple targets and accurate SNP phasing. G3 5, 2801-2808.

O’Connell, K., Jinks-Robertson, S. and Petes, T.D. (2015). Elevated genome-wide instability in yeast mutants lacking RNase H activity. Genetics 201, 963-975.

Cho, J.E., Kim, N. and Jinks-Robertson, S. (2015). Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter. Nucleic Acids Res. 43, 9306-9313.

Lehner, K. and Jinks-Robertson, S. (2014). Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast. Genetics 198, 519-530.

Guo, X. and Jinks-Robertson, S. (2013). Roles of exonucleases and translesion synthesis DNA polymerases during mitotic gap repair in yeast. DNA Repair 12, 1024-1030.

Guo, X. and Jinks-Robertson, S. (2013). Removal of N-6-methyladenine by the nucleotide excision repair pathway triggers the repair of mismatches in yeast gap-repair intermediates. DNA Repair 12, 1053-1061.

Kim, N. and Jinks-Robertson, S. (2013). RNA:DNA hybrids initiate quasi-palindrome-associated mutations in highly transcribed yeast DNA. PLoS Genet. 9, e100392.

Boiteux, S. and Jinks-Robertson, S. (2013). DNA repair mechanisms and the bypass of DNA damage. Genetics, 193, 1025-64.

Mitchel, K., Lehner, K. and Jinks-Robertson, S. (2013). Heteroduplex DNA position defines the roles of the Sgs1, Srs2 nad Mph1 helicases in promoting distinct recombination outcomes. PLoS Genet., 9, e1003340

Kozmin, S.G. and Jinks-Robertson, S. (2013). UV-induced mutagenesis in non-dividing yeast cells. Genetics, 193, 803-817.

Cho, J.-E., Kim, N. and Jinks-Robertson, S. (2013). Two distinct mechanisms of Topoisomerase 1-dependent mutatgenesis in yeast. DNA Repair, 1, 205-11.

Kim N, Jinks-Robertson, S. (2012). Transcription as a source of genome instability. Nat. Rev. Genet. 13, 204-214.

Lehner K, Mudrak SV, Minesinger BK, Jinks-Robertson S. (2012). Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae. Genetics 190, 501-510.

Kim, N., Mudrak, S.V. and Jinks-Robertson, S. (2011). The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenous AP sites in yeast. DNA Repair 10, 1262-1271.

Kim, N. and Jinks-Robertson, S. (2011). Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. DNA Repair 10, 953-960.

Lippert, M.J., Kim, N., Cho, J.E., Larson, R.P., Schoenly, N.E., O’Shea, S.H. and Jinks-Robertson, S. (2011). Role for topoisomerase 1 in transcription-associated mutagenesis in yeast. Proc. Natl. Acad. Sci. USA 108, 698-703.

Kim, N., Huang, S.Y., Williams, J.S., Li, Y.C., Clark, A.B., Cho, J.E., Kunkel, T.A., Pommier, Y., and Jinks-Robertson, S. (2011) Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. Science 24, 1561-1564.

Kim, N., and Jinks-Robertson, S. (2010) Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled necleotide excision repair. Mol. Cell. Bio. 30, 3206-3215.

Mitchel, K., Zhang, H., Welz-Voegele, C., and Jinks-Robertson, S. (2010) Molecular structures of crossover and noncrossover intermediates during gap repair in yeast: Implications for recombination. Mol. Cell. 38, 211-222.

Mudrak, S.V., Welz-Voegele, C., and Jinks-Robertson, S. (2009) The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast. Mol. Cell. Biol. 29, 5316-5326.

Kim, N. and Jinks-Robertson, S. (2009) dUTP incorporation into genomic DNA is linked to transcription in yeast. Nature 459,1150-1153.

Lehner, K. and Jinks-Robertson, S. (2009) The mismatch repair system promotes DNA polymerase zeta-dependent translesion synthesis in yeast. Proc. Natl. Acad. Sci. USA 106, 5749-5754.

Welz-Voegele, C. and Jinks-Robertson, S. (2008) Sequence divergence impedes crossover more than noncrossover events during mitotic gap repair in yeast. Genetics 179, 1251-1262.

Stone, J.E., Ozbirn, R.G., Petes, T.D and Jinks-Robertson, S. (2008). Role of proliferating cell nuclear antigen interactions in the mismatch repair-dependent processing of mitotic and meiotic recombination intermediates in yeast. Genetics 178, 1221-1236.

Abdulovic, A.L., Minesinger, B.K. and Jinks-Robertson, S. (2008). The effect of sequence context on spontaneious Polzeta-dependent mutagenesis in Saccharomyces cerevisiae. Nucleic Acids Res. 36, 2082-2093.

Welz-Voegele, C. and Jinks-Robertson, S. (2008). Sequence divergence impedes crossover more than noncrossover events during mitotic gap repair in yeast. Genetics 179, 1251-1262.

Abdulovic, A.L., Minesinger, B.K. and Jinks-Robertson, S. (2007). Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Poleta. DNA Repair (Amst). 6, 1307-1318.

Kow, Y.W., Bao, G., Reeves, J.W., Jinks-Robertson, S. and Crouse, G.F. (2007). Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands. Proc. Natl. Acad. Sci. USA 104, 11352-11357.

Abdulovic, A.L., Kim, N. and Jinks-Robertson, S. (2006). Mutagenesis and the three R’s in yeast. DNA Repair 5, 409-421.

Abdulovic, A.L. and Jinks-Robertson, S. (2006). The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: novel insight into Polζ and Polη dependent frameshift mutagenesis. Genetics 172, 1487-1498.

Sabbioneda, S., Minesinger, B.K., Giannattasio, M., Plevani, P., Muzi-Falconi, M. and Jinks-Robertson, S. (2005). The 9-1-1 checkpoint clamp physically interacts with Polζ and is partially required for spontaneous Polζ-dependent mutagenesis in Sacchaormyces cerevisiae. J. Biol. Chem. 280, 38657-38665.

Minesinger, B.K. and Jinks-Robertson, S. (2005). Roles of RAD6 epistasis group members in spontaneous Polζ-dependent translesion synthesis in Saccharomyces cerevisiae. Genetics 169, 1939-1955.

Lippert, M.J., Freedman, J.A., Barber, M.A. and Jinks-Robertson, S. (2004). Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast. Mol. Cell. Biol. 24, 4801-4809.

Welz-Voegele, C., Stone, J.E., Tran, P.T., Kearney, H.M., Liskay, R.M., Petes, T.D. and Jinks-Robertson, S. (2002). Separation-of-function alleles of the yeast PMS1 mismatch repair gene differentially affect recombination- and replication-related processes. Genetics 162, 1131-1145.

Harfe, B.D. and Jinks-Robertson, S (2000). DNA polymerase ζ introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. Mol. Cell 6, 1491-1499.

Saxe, D., Datta, A. and Jinks-Robertson, S. (2000). Stimulation of mitotic gene conversion and crossover events by high levels of RNA polymerase II transcription in yeast. Mol. Cell. Biol. 20, 5404-5414.

Chen, W. and Jinks-Robertson, S. (1998). Mismatch repair proteins regulate heteroduplex formation during mitotic recombination in yeast. Mol. Cell. Biol. 18, 6525-6537.

Datta, A., Hendrix, M., Lipsitch, M. and Jinks-Robertson, S. (1997). Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic recombination in yeast. Proc. Natl. Acad. Sci. USA 94, 9757-9762.

Greene, C.N. and Jinks-Robertson, S. (1996). Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins. Mol. Cell. Biol. 17, 2844-2850.

Datta, A. and Jinks-Robertson, S. (1995). Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science 268, 1616-1619.