Stacy Horner, PhD – Publications

Assistant Professor
Co-Director, Center for RNA Biology

research • biography • lab members • publications • lab website

Google Scholar Profile 

Representative Publications:

Gokhale NS, Horner SM. RNA modifications go viral. PLoS Pathog. 2017;13(3):e1006188. PMID:28278189.

Gokhale NS, Horner SM. Knotty Zika virus blocks exonuclease to produce subgenomic flaviviral RNAs. Cell Host Microbe. 2017. 21(1). PMID: 28081439.

McFadden MJ, Gokhale NS, Horner SM. Protect this house: cytosolic sensing of viruses. Curr Opin Virology. 2017; 22:36-43. PMID: 27951430.

Jarret A, McFarland AP*, Horner SM*, Kell A, Schwerk J, Hong M, Badil S, Joslyn RC, Baker DP, Carrington M, Hagedorn CH, Gale M, Jr., Savan R. Hepatitis C virus-induced microRNAs dampen interferon mediated antiviral signaling. Nat Med. 2016. 22: 1475-1481. PMID:27841874. *Equal contribution

horner-chm-cover-nov-2016Gokhale NS, McIntyre ABR, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, Hopcraft,SE, Quicke KM, Vazquez C, Willer J, Ilkayeca OR, Law BA, Holley CL, Garcia-Blanco MA, Evans MJ, Suthar MS, Bradrick SS, Mason CE, Horner SM. N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016; pii: S1931-3128(16)30393-6 PMID: 27773535 Featured on the cover.
Beachboard, DC, Horner SM. Innate immune evasion strategies of DNA and RNA viruses. Curr Opin Microbiol. 2016; 32:113-119. PMCID: PMC4475425.

Kennedy EM, Bogerd HP, Kornepati AVR, Kang B, Ghoshal D, Marshall JB, Poling BC, Tsai G, Gokhale N, Horner SM, Cullen BR. Post-transcriptional m6A editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe. 2016; 19(5): 675-85. PMCID: PMC4867121.

Aligeti M*, Roder A*, Horner SM. Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. J Virol. 2015;89(22):11523-33. PMCID: 4645646. *Equal Contribution

Vazquez C, Horner SM. MAVS Coordination of Antiviral Innate Immunity. J Virol. 2015;89(14):6974-7. PMCID: 4473567.

Horner SM*, Naggie S*. Successes and Challenges on the Road to Cure Hepatitis C. PLoS Pathog. 2015;11(6):e1004854. PMCID: 4472668. *Corresponding Author

Horner SM*, Wilkins C, Badil S, Iskarpatyoti J, Gale M, Jr. Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking. PLoS One. 2015;10(3):e0117963. PMCID: 4348417. *Corresponding Author

Horner SM. Insights into antiviral innate immunity revealed by studying hepatitis C virus. Cytokine. 2015;74(2):190-7. PMCID: 4475425.

Gokhale NS, Vazquez C, Horner SM. Hepatitis C virus: Strategies to evade antiviral responses. Future Virol. 2014;9(12):1061-75. PMCID: 4430848.

McFarland AP, Horner SM, Jarret A, Joslyn RC, Bindewald E, Shapiro BA, Delker DA, Hagedorn CH, Carrington M, Gale M, Jr., Savan R. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. Nat Immunol. 2014;15(1):72-9. PMID: 24241692.

Horner SM. Activation and Evasion of Antiviral Innate Immunity by Hepatitis C Virus. J Mol Biol. 2014;426(6):1198-209. PMID: 24184198.

Horner SM, Gale M, Jr. Regulation of hepatic innate immunity by hepatitis C virus. Nat Med. 2013;19(7):879-88. PMID: 23836238.

Horner SM, Park HS, Gale M, Jr. Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix alpha0. J Virol. 2012;86(6):3112-20. PMID: 22238314.

Patel MR, Loo YM, Horner SM, Gale M, Jr., Malik HS. Convergent evolution of escape from hepaciviral antagonism in primates. PLoS Biol. 2012;10(3):e1001282. PMID: 22427742.

Horner SM, Liu HM, Park HS, Briley J, Gale M, Jr. Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc Natl Acad Sci U S A. 2011. PMID: 21844353.

For a complete list of publications, click here.