Stacy Horner, PhD – Publications

Associate Professor
Co-Director, Center for RNA Biology

research • biography • lab members • publications • lab website

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Representative Publications:

McFadden MJ*, Sacco MT*, Murphy KA, Park M, Gokhale NS, Somfleth KY, Horner SM. FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression. bioRxiv. 2021:2021.07.23.453596. doi: 10.1101/2021.07.23.453596.  *Co-first.

Sacco MT, Horner SM. Flipping the script: viral capitalization of RNA modifications. Briefings in Functional Genomics. 2021;20(2):86-93. doi: 10.1093/bfgp/elaa025. PMID: 33401298. PMCID: PMC8008163.

McFadden MJ, Horner SM. N(6)-Methyladenosine Regulates Host Responses to Viral Infection. Trends Biochem Sci. 2021;46(5):366-77. doi: 10.1016/j.tibs.2020.11.008. PMID: 33309325. PMCID: PMC8052259.

McFadden MJ, McIntyre ABR, Mourelatos H, Abell NS, Gokhale NS, Ipas H, Xhemalçe B, Mason CE, Horner SM. Post-Transcriptional Regulation of Antiviral Gene Expression by N6-Methyladenosine. Cell Rep. 2021;34(9):108798. doi: 10.1016/j.celrep.2021.108798. PMID: 33657363. PMCID: PMC7981787.

da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A. Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell. 2020;183(5):1185-201 e20. PMID: 33242417.

Price AM, Hayer KE, McIntyre ABR, Gokhale NS, Abebe JS, Della Fera AN, Mason CE, Horner SM, Wilson AC, Depledge DP, Weitzman MD. Direct RNA sequencing reveals m(6)A modifications on adenovirus RNA are necessary for efficient splicing. Nat Commun. 2020;11(1):6016. PMCID: 7691994.

Williams GD, Gokhale NS, Snider DL, Horner SM. 2020. The mRNA cap 2′-O-methyltransferase CMTR1 regulates the expression of certain interferon-stimulated genes. mSphere. 2020; 5(3):e00202-20. PMCID: 7227766.

McIntyre ABR, Gokhale NS, Cerchietti L, Jaffrey SR, Horner SM*, Mason CE*. Limits in the detection of m(6)A changes using MeRIP/m(6)A-seq. Sci Rep. 2020;10(1):6590. PMCID: 7170965. *Co-corresponding.

Kwock JT, Handfield C, Suwanpradid J, Hoang P, McFadden MJ, Labagnara KF, Floyd L, Shannon J, Uppala R, Sarkar MK, Gudjonsson JE, Corcoran DL, Lazear HM, Sempowski G, Horner SM, MacLeod AS. IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection. Sci Adv. 2020;6(14):eaay3245. PMCID: 7112749.

Gokhale NS, McIntyre ABR, Mattocks MD, Lazear HM, Holley CL, Mason CE*, and Horner SM*. Altered m6A modification of cellular transcripts influences Flaviviridae infection. Molecular Cell. 2020;77(3):542-55 e8. PMCID: 7007864. *Co-corresponding. Highlighted in Nature Reviews Molecular Cell Biology,Featured on the cover of Molecular Cell.

Vazquez C, Tan CY, Horner SM. Hepatitis C virus infection is inhibited by a non-canonical antiviral signaling pathway targeted by NS3-NS4A. J Virol. 2019;93(23):e00725-19. PMCID: 6854490.

Beachboard DC, Park M, Vijayan M, Snider DL, Fernando DJ, Williams GD, Stanley S, McFadden MJ, and Horner SM. The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor–associated factor 3 (TRAF3). J Biol Chem. 2019; 294(39):14231-14240. PMCID: 31375559.

Williams GD, Gokhale NS, Horner SM. Regulation of Viral Infection by the RNA Modification N6-Methyladenosine. Annu Rev Virol. 2019;6(1):235-53. PMID: 31283446.

Roder AE, Horner SM. Measuring Hepatitis C Virus Envelopment by Using a Proteinase K Protection Assay. Methods Mol Biol. 2019;1911:209-17. PMCID: 6357228.

Roder AE, Vazquez C, Horner SM. The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein. PLoS Pathog. 2019;15(2):e1007163. PMCID: 6382253.

Dethoff EA, Boerneke MA, Gokhale NS, Muhire BM, Martin DP, Sacco MT, McFadden MJ, Weinstein JA, Messer WB*, Horner SM*, Weeks KM*. Pervasive tertiary structure in the dengue virus RNA genome. Proc Natl Acad Sci U S A. 2018;115(45):11513-8. PMCID: 6233125. *Co-corresponding

Imam H, Khan M, Gokhale NS, McIntyre ABR, Kim GW, Jang JY, Kim SJ, Mason CE, Horner SM, Siddiqui A. N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle. Proc Natl Acad Sci U S A. 2018;115(35):8829-34. PMCID: 6126736.

Wang L, Pittman KJ, Barker JR, Salinas RE, Stanaway IB, Williams GD, Carroll RJ, Balmat T, Ingham A, Gopalakrishnan AM, Gibbs KD, Antonia AL, e MN, Heitman J, Lee SC, Jarvik GP, Denny JC, Horner SM, DeLong MR, Valdivia RH, Crosslin DR, Ko DC. An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease. Cell Host Microbe. 2018;24(2):308-23 e6. PMCID: 6093297.

Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM. A potentially abundant junctional RNA motif stabilized by m(6)A and Mg(2). Nat Commun. 2018;9(1):2761. PMCID: 6050335.

McFadden MJ, Mitchell-Dick A, Vazquez C, Roder AE, Labagnara KF, McMahon JJ, Silver DL, Horner SM. A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. Viruses. 2018;10(2). doi: 10.3390/v10020095. PMCID: 5850402.

For a complete list of publications, click here.