Graham Williams, PhD
DUMC Box 3053
Durham, NC 27710
Phone: (919) 684-2319
Fax: (919) 684-2790
I received by PhD at Washington University in Saint Louis in fall 2017. During my doctoral studies, I focused on the evolution of influenza A virus and how this impacts viral replication and disease. I recently joined Dr. Horner’s lab to examine host responses to viral infection and innate immune mechanisms. Infection induces a host transcriptional burst, including the induction of hundreds of interferon-stimulated genes. These genes must be heavily regulated to successfully contain pathogens, but also minimize subsequent immunopathology. How post-transcriptional regulation of host RNAs, RNA modifications (the epitranscriptome) and innate immunity interface during virus-host interactions is currently incompletely understood.
Personal Interests: Soccer and cycling
Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication. Williams GD, Townsend D, Wylie KM, Kim PJ, Amarasinghe GK, Kutluay SB, Boon ACM. Nat Commun. 2018 Jan 31;9(1):465. doi: 10.1038/s41467-018-02886-w.
A North American H7N3 Influenza Virus Supports Reassortment with 2009 Pandemic H1N1 and Induces Disease in Mice without Prior Adaptation. Williams GD, Pinto AK, Doll B, Boon AC. J Virol. 2016 Apr 14;90(9):4796-806. doi: 10.1128/JVI.02761-15. Print 2016 May.
Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families. Pinto AK, Williams GD, Szretter KJ, White JP, Proença-Módena JL, Liu G, Olejnik J, Brien JD, Ebihara H, Mühlberger E, Amarasinghe G, Diamond MS, Boon AC. J Virol. 2015 Sep;89(18):9465-76. doi: 10.1128/JVI.00996-15. Epub 2015 Jul 8.
Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice. DesRochers BL, Chen RE, Gounder AP, Pinto AK, Bricker T, Linton CN, Rogers CD, Williams GD, Webby RJ, Boon AC. Virology. 2016 Jul;494:89-99. doi: 10.1016/j.virol.2016.04.013. Epub 2016 Apr 20.