Soo Chan Lee, PhD – Publications

research • biography • publications

Lee, Soo Chan, Li, A., Calo, S., Inoue, M., Tonthat, N. K., Bain, J. M., Louw, J., Shinohara, M., Erwig, L.,  Schumacher, M., Ko, D., and Heitman, J. Calcineurin orchestrates dimorphic transitions, antifungal drug responses, and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. Molecular Microbiology. 2015. 97:844-865

Lee, Soo Chan* and Heitman, J. 2014. Sex in the Mucoralean fungi. Mycoses. Suppl. 3:18-24.
* corresponding author.

Calo, S., Shertz, C., Lee, Soo Chan, Bastidas, R. J., Nicolas, F. E., Granek, J. A., Mieczkowski, P., Torres-Martinez, S., Ruiz-Vazquez, R. M., Cardenas, M. E., and Heitman, J. 2014. Epimutations evoke antifungal drug resistance in the human fungal pathogen Mucor via RNAi. Nature. 513:555-558.

Lee, Soo Chan*, Billmyre, B. R., Li, A., Carson, S., Sykes, S. M., Huh, E. Y., Mieczkowski, P., Ko, D., Cuomo, C. A., and Heitman, J*. 2014. Analysis of a foodborne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. mBio. 5:e01390-14.
* co-corresponding authors.

Lee, Soo Chan*, Sun, S*., and Heitman, J. 2014. Unseen sex in ancient virgin fungi. New Phytologist. 201:3-5.
*co-first authors.

Lee, Soo Chan, Li, A., Calo, S., and Heitman, J. 2013. Calcineurin plays key roles in the dimorphic transition and virulence in the human pathogenic zygomycete Mucor circinelloides. PLOS Pathogens. 9: e1003625.

Lee, Soo Chan, Ristaino, J., and Heitman, J. 2012. Parallels in intercellular communication in oomycete and fungl pathogens of plants and humans. PLOS Pathogens. 12:e1003028. Pearls Review.

Lee, Soo Chan, Phadke, S., Sun, S., and Heitman, J. 2012. Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires theAmt1/2 ammonium permeases. Eukaryotic Cell. 11:1391-1398.

Lee, Soo Chan and Heitman, 2012. J. Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating in. Eukaryotic Cell. 11:783-794.

Bastidas, R. J., Shertz, C. A., Soo Chan Lee, Heitman, J., and Cardenas, M. E. 2012. Rapamycin exerts antifungal activity in vitro and in vivo in Mucor circinelloides via FKBP12 dependent inhibition of TOR. Eukaryotic Cell. 11:270-281.

Wang, X., Li, W., Sun, S., Kozubowski, L., Lee, Soo Chan, Feretzaki, M., Heitman, J. 2012. Know your enemy: how to build and vanquish a global fungal scourge. Mycopathologia. 173:295-301.

Li, C. H., Cervantes, M., Springer, D. J., Ruiz-Vazquez, R. M., Torres-Martinez, S. R., Heitman, J.*, and Lee, Soo Chan*. 2011. Sporangiospore size dimorphism is linked to virulence of Mucor circinelloides species subcomplex. PLOS Pathogens. 7:e1002086.
* co-corresponding authors
– evaluated by the Faculty of 1000
– cover image

Gryganskyi, A. P., Lee, Soo Chan, Litvintseva, A. P., Smith, M. E., Bonito, G., Porter, G. M., Anishchenko, I. M., Heitman, J., Vilgalys, R. 2010. Structure, function, and phylogeny of the mating locus in the Rhizopus oryzae  PLOS ONE. 5: e15273.

Lee, Soo Chan, Corradi, N., Doan, S., Dietrich, F. S., Keeling, P. J., and Heitman, J. 2010. Evolution of the sex-related locus and genomic features shared in microsporidia and fungi. PLOS ONE. 5: e10539.

Lee, Soo Chan, Ni, M., Li, W., Shertz, C., and Heitman, J. 2010. The evolution of sex: a perspective from the fungal kingdom. Microbiology and Molecular Biology Reviews. 74: 298-340.

Lee, Soo Chan, Louis M. Weiss, and Joseph Heitman. 2009. Generation of genetic diversity in microsporidia via sexual reproduction and horizontal gene transfer. Communicative & Integrative Biology. 2:5, 414-417.

Kozubowski, L*, Lee, Soo Chan*, and Heitman, J. 2009. Signaling pathways in the pathogenesis of Cryptococcus. Cellular Microbiology. 11:370-380.
*co-first authors

Lee, Soo Chan, Corradi, N., Byrnes, E. J., Torres-Martinez, S., Dietrich, F. S., Keeling, P. J., and Heitman, J. 2008. Microsporidia evolved from ancestral sexual fungi. Current Biology. 18:1675-1679.
This paper was  highlighted and commented on in:
– Surridge, C. 2008. Sex and the parasitic fungi. Nature Reviews Microbiology. 6:873.
– Dyer, P. 2008. Microsporidia sex – a missing link to fungi. Current Biology. 18: R1012-R1014

Lee, Soo Chan and Shaw, B.D. 2008. ArfB links protein lipidation and endocytosis to polarized growth of Aspergillus nidulans. Communicative & Integrative Biology. 1:51-52.

Lee, Soo Chan, Schmidtke, S.N., Dangott, L. J., and Shaw, B.D. 2008. Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth. Eukaryotic Cell.7:1278-1288.

Lee, Soo Chan and Shaw, B.D. 2008. Localization and function of ADP ribosylation factor A in Aspergillus nidulans. FEMS Microbiology Letters. 283:216-222.

Lee, Soo Chan and Shaw, B.D. 2007. A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis. Molecular Microbiology. 63: 1054-1068.

Lee, S. J., Lee, Soo Chan, Choi, S. H., Chung, M. K, Rhie, H. G., and Lee, Ho Sa. 2001 Effect of ArsA, arsenite-specific ATPase, on inhibition of cell division in Escherichia coli. Journal of  Microbiology and Biotechnology. 11: 825-830.

  • Book Chapters

Mendoza, L., Vilela, R., Volz, K., Ibrahim, A., Voigt, K., and Soo Chan Lee*. A book chapter: Human fungal pathogens of Mucorales and Entomorphthorales in the monograph “Human Fungal Pathogens”. 2014. Cold Spring Harbor Laboratory. ISBN: 978-1-621820-75-8. 483-515.
* Senior author

Lee, Soo Chan, Heitman, J., and Ironside, J. A book chapter: Sex in the microsporidia in the book “Microsporidia: Pathogens of Opportunity”. 2014. Wiley Press. ISBN: 978-1-118-39522-6. 231-243.