So Young Kim, PhD – Publications

Research Assistant Professor
Director, RNAi Screening Facility 

research • publications

Representative Publications:

Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K. The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24- stem cell-like breast cancer cells in human tumors. J Clin Invest. 2011 Jun 1. p: 44745.

Johannessen, CM, Boehm, JS, Kim SY, Thomas, S, Wardwell, L, Johnson, L, Emery, C, Stransky, N, Cogdill, AP, Barretina, J, Caponigro, G, Hieronymus, H, Murray, RR, Salehi-Ashtiani, K, Hill, D, Vidal, M, Zhao, J, Yang, X, Alkan, O, Kim, S, Harris, J, Willson, CJ, Myer, VE, Finan, PM, Root, DE, Roberts, TM, Golub T, Flaherty, KT, Dummer, R, Weber, BL, Sellers, WR, Schlegel, R, Wargo, JA, Hahn, WC, Garraway, LA. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010 468(7326):968-72.

Kalender A*, Selvaraj A*, Kim SY*, Gulati P, Brûlé S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab. 2010 May 5;11(5):390-401.
*These authors contributed equally to this work.

Kim, SY, Dunn, IF, Firestein, R, Gupta.P, Wardwell, L, Repich, K, Schinzel, AC, Wittner, B, Silver, SJ, Root, DE, Boehm, JS, Ramaswamy, S, Lander ES, and Hahn, WC. CK1e is required for breast cancers dependent on β-catenin activity. PLoS One. 2010 Feb 1;5(2):e8979.

Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG,Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O’Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M. SOX2 Is an Amplified Oncogene in Lung and Esophageal Squamous Cell Carcinomas. Nat Genet. 2009 Nov;41(11):1238-42.

Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC. Systematic RNA interference reveals that oncogenic KRAS-driven cancers required TBK1.Nature. 2009 Nov 5;462(7269):108-12.

Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.Cancer Cell. 2009 Jul 7;16(1):21-32.

Hahn WC, Dunn IF, Kim SY, Schinzel AC, Firestein R, Guney I, Boehm JS. Integrative approaches to understanding cancer. Biochim Biophys Acta. 2009 Jun;1790(6):478-84.

Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG. Synthetic Lethal Interaction Between Oncogenic KRAS Dependency and Suppression of STK33 in Human Cancer Cells. Cell. 2009 May 29;137(5):821-34.

Firestein, R, Bass, AJ, Kim SY, Dunn, IF, Silver, SJ, Guney, I, Freed, E, Ligon, AH, Vena, N, Ogino, S, Chheda, MG, Tamayo, P, Finn, S, Shrestha, Y, Boehm, JS, Jain, S, Bojarski, E, Mermel, C, Barretina, J, Chan, JA, Baselga, J, Tabernero, J, Root, DE, Fuchs, CS, Loda, M, Shivdasani, RA, Meyerson, M, and Hahn, WC. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25;455(7212):547-51.

Kim, SY and Hahn, WC. Cancer genomics: integrating form and function. Carcinogenesis. 2007 Jul;28(7):1387-92.

Boehm, JS, Zhao, JJ, Yao, J, Kim, SY, Firestein, R, Dunn, IF, Sjostrom, SK, Garraway, LA, Weremowicz, S, Richardson, AL, Greulich, H, Stewart, CJ, Mulvey, LA, Shen, RR, Ambrogio, L, Hirozane-Kishikawa, T, Hill, DE, Vidal, M, Meyerson, M, Grenier, JK, Hinkle, G, Root, DE, Roberts, TM, Lander, ES, Polyak, K, and Hahn, WC. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007 Jun 15;129(6):1065-79.

Moffat, J, Grueneberg, DA, Yang, X, Kim, SY, Kloepfer, AM, Hinkle, G, Piqani, B, Eisenhaure, TM, Luo, B, Grenier, JK, Carpenter, AE, Foo, SY, Stewart, SA, Stockwell, BR, Hacohen, N, Hahn, WC, Lander, ES, Sabatini, DM, and Root, DE. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.  Cell. 2006 Mar 24;124(6):1283-98.

Nobukuni, T, Joaquin M, Roccio, M, Dann, SG, Kim, SY, Gulati, P, Byfield, MP, Backer, JM, Natt, F, Bos, JL, Zwartkruis, FJ, and Thomas, G. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3 OH-kinase. Proc Natl Acad Sci. 2005 Oct 4;102(40):14238-43.

Herbst, A, Salghetti SE, Kim, SY, and Tansey, WP.  Multiple cell-type-specific elements regulate Myc protein stability.Oncogene. 2004 May 6;23(21):3863-71.

Kim, SY, Herbst, A, Tworkowski, KA, Salghetti, SE, and Tansey, WP.  Skp2 regulates Myc protein stability and activity. Mol Cell. 2003 May;11(5):1177-88.

Méndez, J, Zou-Yang, XH, Kim, SY, Hidaka, M, Tansey, WP, and Stillman, B. (2002).  Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol Cell. 2002 Mar;9(3):481-91.

Salghetti, SE, Kim, SY, and Tansey, WP.  Destruction of Myc by ubiquitin-mediated proteolysis:  cancer-associated and transforming mutations stabilize Myc. EMBO J. 1999 Feb 1;18(3):717-26.