So Young Kim, PhD, Publications

research

Google Scholar Profile

Selected Publications

Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct 5;171(2):481-494. PMID: 28985567.

Subramanian S, Gottschalk WK, Kim SY, Roses AD, Chiba-Falek O. The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster. Biochim Biophys Acta. 2017 Mar;1863(3):810-816. PMID: 28065845.

Keenan M, Liu B, Tang X, Wu J, Cyr D, Stevens R, Ilkayeva, O, Huang Z, Tollini L, Murphy S, Lucas J, Muoio D, Kim SY, Chi JT. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. PLoS Genet. 2015 Oct 9;11(10):e1005599. PMID: 26452058.

Moody S, Schinzel A, Singh S, Izzo F, Strickland M, Luo L, Thomas S, Boehm J, Kim SY, Wang Z, Hahn WC. PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling. Oncogene. 2014 Jun 9;0. PMID: 24909179.

Barrows NJ, Jamison SF, Bradrick SS, Le Sommer C, Kim SY, Pearson J, Garcia-Blanco MA. Functional genomics approach for the identification of human host factors supporting dengue viral propagation. Methods Mol Biol. 2014;1138:285-99. PMID: 24696344.

Hagerstrand D, Tong A, Schumacher SE, Ilic N, Shen RR, Cheung HW, Vazquez F, Shrestha Y, Kim SY, Giacomelli AO, Rosenbluh J, Schinzel AC, Spardy NA, Barbie DA, Mermel CH, Weir BA, Garraway LA, Tamayo P, Mesirov JP, Beroukhim R, Hahn WC. Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer driversPMID: 23764425.. Cancer Discov. 2013 Sep;3(9):1044-57. PMID: 23764425.

Serra V, Eichhorn P, Garcia-Garcia C, Ibrahim Y, Prudkin L, Sanchez G, Rodriguez O, Anton P, Parra JL, Marlow S, Scaltriti M, Perez-Garcia J, Prat A, Arribas J, Hahn WC, Kim SY*, Baselga J*. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. J Clin Invest, 2013 Jun 3;123(6):2551-63. PMID: 23635776.*Co-corresponding authors.

 Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K. The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24- stem cell-like breast cancer cells in human tumors. J Clin Invest. 2011 Jul;121(7):2723-35. PMID: 21633165.

 Johannessen, CM, Boehm, JS, Kim SY, Thomas, S, Wardwell, L, Johnson, L, Emery, C, Stransky, N, Cogdill, AP, Barretina, J, Caponigro, G, Hieronymus, H, Murray, RR, Salehi-Ashtiani, K, Hill, D, Vidal, M, Zhao, J, Yang, X, Alkan, O, Kim, S, Harris, J, Willson, CJ, Myer, VE, Finan, PM, Root, DE, Roberts, TM, Golub T, Flaherty, KT, Dummer, R, Weber, BL, Sellers, WR, Schlegel, R, Wargo, JA, Hahn, WC, Garraway, LA. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010 468(7326):968-72. PMID: 21107320.

Kalender A*, Selvaraj A*, Kim SY*, Gulati P, Brûlé S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab. 2010 May 5;11(5):390-401. PMID: 20444419.*These authors contributed equally to this work.

Kim, SY*, Dunn, IF*, Firestein, R, Gupta.P, Wardwell, L, Repich, K, Schinzel, AC, Wittner, B, Silver, SJ, Root, DE, Boehm, JS, Ramaswamy, S, Lander ES, and Hahn, WC. CK1e is required for breast cancers dependent on β-catenin activity. PLoS One. 2010 Feb 1;5(2):e8979. PMID: 20126544.*These authors contributed equally to this work.

Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 2009 Jul 7;16(1):21-32. PMID: 19573809.

Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC. Systematic RNA interference reveals that oncogenic KRAS-driven cancers required TBK1. Nature. 2009 Nov 5;462(7269):108-12. PMID: 19847166.

Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O’Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M. (2009) SOX2 Is an Amplified Oncogene in Lung and Esophageal Squamous Cell Carcinomas. Nat Genet. 41(11):1238-42. PMID: 19801978.

 Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG. Synthetic Lethal Interaction Between Oncogenic KRAS Dependency and Suppression of STK33 in Human Cancer Cells. Cell. 2009 May 29;137(5):821-34. PMID: 19490892.

 Hahn WC, Dunn IF, Kim SY, Schinzel AC, Firestein R, Guney I, Boehm JS. (2009) Integrative approaches to understanding cancer. Biochim Biophys Acta. 1790(6):478-84. PMID: 19364473.

 Moffat, J, Grueneberg, DA, Yang, X, Kim, SY, Kloepfer, AM, Hinkle, G, Piqani, B, Eisenhaure, TM, Luo, B, Grenier, JK, Carpenter, AE, Foo, SY, Stewart, SA, Stockwell, BR, Hacohen, N, Hahn, WC, Lander, ES, Sabatini, DM, and Root, DE. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.  Cell. 2006 Mar 24;124(6):1283-98. PMID: 16564017.

 Kim, SY and Hahn, WC. Cancer genomics: integrating form and function. Carcinogenesis. 2007 Jul;28(7):1387-92. PMID: 17434922.

 Firestein, R, Bass, AJ, Kim SY, Dunn, IF, Silver, SJ, Guney, I, Freed, E, Ligon, AH, Vena, N, Ogino, S, Chheda, MG, Tamayo, P, Finn, S, Shrestha, Y, Boehm, JS, Jain, S, Bojarski, E, Mermel, C, Barretina, J, Chan, JA, Baselga, J, Tabernero, J, Root, DE, Fuchs, CS, Loda, M, Shivdasani, RA, Meyerson, M, and Hahn, WC. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25;455(7212):547-51. PMID: 18794900.

Boehm, JS, Zhao, JJ, Yao, J, Kim, SY, Firestein, R, Dunn, IF, Sjostrom, SK, Garraway, LA, Weremowicz, S, Richardson, AL, Greulich, H, Stewart, CJ, Mulvey, LA, Shen, RR, Ambrogio, L, Hirozane-Kishikawa, T, Hill, DE, Vidal, M, Meyerson, M, Grenier, JK, Hinkle, G, Root, DE, Roberts, TM, Lander, ES, Polyak, K, and Hahn, WC. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007 Jun 15;129(6):1065-79. PMID: 17574021.