Raphael Valdivia, PhD – Publications

Professor
Vice Dean for Basic Science

research • biography • lab members • publications

Representative Publications:

Kokes, M., Barker, J., Dunn, JD, Nguyen, BD, J, Granek, Valdivia, RH., and Bastidas, R. (2015) Integrating chemical mutagenesis and whole genome sequencing as a platform for forward and reverse genetic analysis in Chlamydia. Cell Host & Microbe (In Press)

Chen YS, Bastidas, RJ, Saka, HA, Carpenter, VK, Richards, KL, Plano GV, and Valdivia, RH (2014) The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling. PLoS Pathog DOI: 10.1371/journal.ppat.1003954

Nguyen BD, Valdivia RH. (2012) Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches. Proc Natl Acad Sci U S A. 109:1263-1268.

Saka HA, Thompson JW, Chen YS, Kumar Y, Dubois LG, Moseley MA, Valdivia RH. (2011) Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms. Mol Microbiol. 82:1185-1203.

Nguyen, B.D., Cunningham, D., Liang, X., Chen, X., Toone, E.J., Raetz, C.R., Zhou, P., and Valdivia, R.H. (2011) Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis. Proc Natl Acad Sci U S A. 108:10284-10289.

Jorgensen, I., Bednar, M.M., Amin, V., Davis, B.K., Ting, J.P., McCafferty, D.G., and Valdivia, R.H. (2011) The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. Cell Host Microbe. 10:21-31.

Spaeth, K.E., Chen, Y.S. and Valdivia, R.H. (2009) The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complex. PLoS Pathog. 5(9):e1000579. [Epub 2009 Sep 11].

Kumar, Y., and Valdivia, R.H. (2009) Leading a sheltered life: Intracellular pathogens and maintenance of vacuolar compartments. Cell Host Microbe. 5:593-601.

Kumar, Y., and Valdivia, R.H. (2008) Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. Cell Host Microbe. 4:159-169.

Cocchiaro, J.L., Kumar, Y., Fischer, E.R., Hackstadt, T., and Valdivia, R.H. (2008) Cytoplasmic lipid droplets are translocated into the lumen of Chlamydia trachomatisparasitophorous vacuole. Proc Natl Acad Sci USA. 105:9379-9384.

 For a complete list of publications, click here.