Nicholas Heaton, PhD – Publications

Associate Professor

Google Scholar Profile

research • biography • lab members • publications

Recent, selected publications

  1. Froggatt HM, Burke KN, Chaparian RR, Miranda HA, Zhu X, Chambers BS, Heaton NS. Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity. PLoS Pathog. 2021 Sep 27;17(9):e1009951. doi: 10.1371/journal.ppat.1009951. Epub ahead of print. PMID: 34570829.


  1. Froggatt HM, Harding AT, Chaparian RR, Heaton NS. ETV7 limits antiviral gene expression and control of influenza viruses. Sci Signal. 2021 Jul 13;14(691):eabe1194. doi: 10.1126/scisignal.abe1194. PMID: 34257104


  1. Trimarco JD, Heaton BE, Chaparian RR, Burke KN, Binder RA, Gray GC, Smith CM, Menachery VD, Heaton NS. TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2. PLoS Pathog. 2021 May 27;17(5):e1009599. doi: 10.1371/journal.ppat.1009599. PMID: 34043740; PMCID: PMC8189496.


  1. Luo Z, Girton AW, Heaton BE, Heaton NS. Engineered influenza virions reveal the contributions of non-hemagglutinin structural proteins to vaccine mediated protection. J Virol. 2021 Mar 3;95(10):e02021-20. doi: 10.1128/JVI.02021-20. Epub ahead of print. PMID: 33658342; PMCID: PMC8139674.


  1. Harding AT, Goff MA, Froggatt HM, Lim JK, Heaton NS. GPER1 is required to protect fetal health from maternal inflammation. Science. 2021 Jan 15;371(6526):271-276. doi: 10.1126/science.aba9001. PMID: 33446553; PMCID: PMC8060949.


  1. Froggatt HM, Heaton BE, Heaton NS. Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLproReporter Assay. Journal of Virology. 2020 Oct 27;94(22):e01265-20. doi: 10.1128/JVI.01265-20. PMID: 32843534; PMCID: PMC7592234.


  1. Dumm RE, Wellford SA, Moseman EA, Heaton NS. Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses. Cell Reports. 2020 Sep 1;32(9):108103. doi: 10.1016/j.celrep.2020.108103. PMID: 32877682; PMCID: PMC7462569.


  1. Harding AT, Haas GD, Chambers BC, Heaton NS. Influenza viruses that required 10 genomic segments as antiviral therapeutics. PLoS Pathogens. 2019. Nov 15;15(11):e1008098. doi: 10.1371/journal.ppat.1008098. PMID: 31730644


  1. Chambers BS, Heaton BE, Rausch K, Dumm RE, Hamilton JR, Cherry S, Heaton NS. DNA mismatch repair is required for the host innate response and controls cellular fate after influenza virus infection.  Nature Microbiology. 2019. Nov;4(11):1964-1977. doi: 10.1038/s41564-019-0509-3. PMID: 31358986


  1. Dumm RE, Fiege JK, Waring BM, Kuo CT, Langlois RA, Heaton NS. Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function. Nature Communications. 2019 Feb 15;10(1):779. doi: 10.1038/s41467-019-08617-z. PMID: 30770807


  1. Heaton BE, Kennedy EM, Dumm RE, Harding AT, Sacco MT, Sachs D, Heaton NS. A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. Cell Reports. 2017 20(7): p1503-1512.


  1. Harding AT, Heaton BE, Dumm RE, Heaton NS. Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs. mBio. 2017 June 6, Vol. 8 no.3 e00669-17 doi: 10.1128/mBio.00669-17. PMID: 28588131


  1. Hamilton JR, Sachs D, Lim JK, Langlois RA, Palese P, Heaton NS. Club cells surviving influenza A virus infection induce temporary non-specific anti-viral immunity.  Proc Natl. Acad Sci USA.  2016 April 5, vol. 113 no. 14, 3861-3866.  doi: 10.1073/pnas.1522376113.  PMID: 27001854


  1. Fulton BO, Palese P, Heaton NS. Replication competent influenza B reporter viruses as tools for screening antivirals and antibodies. Journal of Virology. 2015 Dec 1;89(23):12226-31. doi: 10.1128/JVI.02164-15. Epub 2015 Sep 23. PMID:26401044


  1. Fulton BO, Sachs D, Beaty SM, Won ST, Lee B, Palese P, Heaton NS. Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins. Cell Reports. 2015 Jun 9;11(9):1331-8. doi: 10.1016/j.celrep.2015.04.054. Epub 2015 May 21. PMID:26004185


For a complete list of publications from Dr. Heaton, please click here.