Nicholas Heaton, PhD – Publications

Assistant Professor

research • biography • lab members • publications

Heaton BE, Kennedy EM, Dumm RE, Harding AT, Sacco MT, Sachs D, Heaton NS. A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.  Cell Reports. 2017 20(7): p1503-1512.  DOI: http://dx.doi.org/10.1016/j.celrep.2017.07.060  PMID: 28813663

Heaton NS. Revisiting the concept of a cytopathic viral infection. PLoS Pathogens. 2017 13(7): e1006409. https://doi.org/10.1371/journal.ppat.1006409. PMID: 28727844

Harding AT, Heaton BE, Dumm RE, Heaton NS. Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs. mBio. 2017 June 6, Vol. 8 no.3 e00669-17 doi: 10.1128/mBio.00669-17. PMID: 28588131

Hamilton JR, Sachs D, Lim JK, Langlois RA, Palese P, Heaton NS.  Club cells surviving influenza A virus infection induce temporary non-specific anti-viral immunity.  Proc Natl. Acad Sci USA.  2016 April 5, vol. 113 no. 14, 3861-3866.  doi: 10.1073/pnas.1522376113.  PMID: 27001854

Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist J, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathy S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, Garcia-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan N, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. Limiting influenza virus, HIV, and dengue virus infection by targeting viral proteostasis. Immunity.  2016 Jan 19;44:46-58 doi: 10.1016/j.immuni.2015.12.017. PMID: 26789921

Fulton BO, Palese P, Heaton NS. Replication competent influenza B reporter viruses as tools for screening antivirals and antibodies. Journal of Virology. 2015 Dec 1;89(23):12226-31. doi: 10.1128/JVI.02164-15. Epub 2015 Sep 23. PMID:26401044

Fulton BO, Sachs D, Beaty SM, Won ST, Lee B, Palese P, Heaton NS. Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins. Cell Reports.  2015 Jun 9;11(9):1331-8. doi: 10.1016/j.celrep.2015.04.054. Epub 2015 May 21. PMID:26004185

Heaton NS, Langlois RA, Sachs D, Lim JK, Palese P, tenOever BR. Long-term survival of influenza virus infected cells drives immunopathology. Journal of Experimental Medicine. 2014 Aug 25;211(9) 1707-1714 doi: 10.1084/jem.20140488 PMID:25135297

Heaton NS, Sachs D, Hai R, Chen C, Palese P.  Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins.  Proc Natl. Acad Sci USA. 2013; Dec 10;110(50):20248-53 doi: 10.1073/pnas.1320524110. Epub 2013 Nov 25. PMID:24277853

Margine I, Krammer F, Hai R, Heaton NS, Tan G, Andrews S, Runstadler J, Wilson O, Albrecht R, García-Sastre A, Palese P. Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect Against Group 2 Influenza A Viruses. Journal of Virology. 2013 Oct;87(19):10435-46. doi: 10.1128/JVI.01715-13. Epub 2013 Jul 31. PMID: 23698304

Heaton NS, Leyva-Grado VH, Tan G, Eggink D, Hai R, Palese P.  In vivo bioluminescent imaging of influenza A virus infection and characterization of novel cross-protective monoclonal antibodies.  Journal of Virology. 2013 87:8272-8281 doi:10.1128/JVI.00969-13 PMID: 23698304

Chou Y, Heaton NS, Gao Q, Palese P, Singer R, Lionnet T.  Colocalization of different influenza viral RNA segments in the cytoplasm of viral budding as shown by single-molecule sensitivity FISH analysis. PLoS Pathogens. 2013; 9(5): e1003358. doi:10.1371/journal.ppat.1003358 PMID: 23671419

Coller KE, Heaton NS, Berger K, Cooper JD, Saunders JL and Randall G. Molecular determinates and dynamics of hepatitis C virus secretion. PLoS Pathogens. 2012;8(1):e1002466. doi:10.1371/journal.ppat.1002466 PMID:22241992

Heaton NS and Randall G. Dengue virus and autophagy. Viruses. 2011; 3(8):1332-1341 PMID: 21994782

Heaton NS and Randall G. Multifaceted roles of lipids in viral infection. Trends in Microbiology. 2011;19(7):368-375 PMID:21530270

Heaton NS and Randall G.  Dengue virus-induced autophagy regulates lipid metabolism. Cell Host and Microbe. 2010; 8(5): 442-432 PMID: 21075353

Heaton NS, Berger KL, Perera R, Kuhn R, and Randall G.  Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl. Acad Sci USA. 2010; 107(40):17345-50 PMID: 20855599

For a complete list of publications, please click here.