Micah Luftig, PhD – Publications

Associate Professor and co-Vice Chair
Director, Center for Virology

research • biography • lab members • alumni • publications

Google Scholar Profile 

Representative Publications:

Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.  Dai J, Luftig MA. J Immunol. 2018 Mar 1;200(5):1727-1736. doi: 10.4049/jimmunol.1701473. Epub 2018 Jan 22. [Abstract] [Full Text]

Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines.  Grossman L, Chang C, Dai J, Nikitin PA, Jima DD, Dave SS, Luftig MA. mSphere. 2017 Nov 29;2(6). pii: e00305-17. doi: 10.1128/mSphere.00305-17. eCollection 2017 Nov-Dec. [Abstract] [Full Text]

Characterization of the EBV-Induced Persistent DNA Damage Response. Hafez AY, Luftig MA.  Viruses. 2017 Dec 1;9(12). pii: E366. doi: 10.3390/v9120366. [Abstract] [Full Text]

c-Myc Represses Transcription of Epstein-Barr Virus Latent Membrane Protein 1 Early after Primary B Cell Infection. Price AM, Messinger JE, Luftig MA. J Virol. 2018 Jan 2;92(2). pii: e01178-17. doi: 10.1128/JVI.01178-17. Print 2018 Jan 15. [Abstract] [Full Text]

The Epstein-Barr virus miR-BHRF1 microRNAs regulate viral gene expression in cis. Poling BC, Price AM, Luftig MA, Cullen BR. Virology. 2017 Dec;512:113-123. doi: 10.1016/j.virol.2017.09.015. [Abstract] [Full Text]

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA. Elife. 2017 Apr 20;6. pii: e22509. doi: 10.7554/eLife.22509. [Full Text]

Limited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization.  Hafez AY, Messinger JE, McFadden K, Fenyofalvi G, Shepard CN, Lenzi GM, Kim B, and Luftig MA. Oncogenesis. 2017 href=”https://www.ncbi.nlm.nih.gov/pubmed/28408983″> [Full Text]

Recent advances in understanding Epstein-Barr virus.  Stanfield BA, Luftig MA.  F1000Res. 2017 Mar 29;6:386. doi: 10.12688/f1000research.10591.1. eCollection 2017. Review.

McFadden K, Hafez AY, Kishton R, Messinger JE, Nikitin PA, Rathmell JC, Luftig MA (2016) Metabolic stress is a barrier to Epstein-Barr virus mediated B-cell immortalization. Proc Natl Acad Sci U S A 113:E782-90. [Article]

Price AM, Luftig, MA (2015) To Be or Not IIb: A Multi-Step Process for Epstein-Barr Virus Latency Establishment and Consequences for B Cell Tumorigenesis. PLoS Pathog 11: e1004656.PLoS Pathog. 2015 Mar 19;11(3):e1004656. doi: 10.1371/journal.ppat.1004656. [Article]

Luftig, M.A. (2014). “Viruses and the DNA Damage Response: Activation and Antagonism.” Annual Review of Virology, Vol. 1:605 -625 (Volume publication date November 2014). [Abstract] [Full Text] [PDF]

Nikitin, P.A., Price, A.M., McFadden, K., Yan, C.M., Luftig M.A. (2014). “Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.” PLoS One. 2014 Jan 30;9(1):e87299. [Abstract] [Article]

Price, A.M., Luftig, M.A. (2014). “Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation.” Adv Virus Res. 88:279-313. [Abstract]

Olive, V., Sabio, E., Bennett, M.J., De Jong, C.S., Biton, A., McGann, J.C., Greaney, S.K., Sodir, N.M., Zhou, A.Y., Balakrishnan, A., Foth, M., Luftig, M.A., Goga, A., Speed, T.P., Xuan, Z., Evan, G.I., Wan, Y., Minella, A.C., He, L. (2013). “A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.” Elife. Oct 15;2:e00822. [Abstract]

Homa, N.J., Salinas, R., Forte, E., Robinson, T.J., Garcia-Blanco, M.A., Luftig, M.A. (2013). “Epstein-Barr virus induces global changes in cellular mRNA isoform usage important for the maintenance of latency.” J Virol. 2013 Sep 11. [Epub ahead of print] [Abstract]

McFadden, K., Luftig, M.A. “Interplay between DNA tumor viruses and the host DNA damage response.” (2013). Curr Top Microbiol Immunol. 371:229-57. Review.[Abstract]

Price, A.M., J.P. Tourigny, E. Forte, R. E. Salinas, S.S. Dave, Luftig, M.A. (2012). “Analysis of EBV-Regulated Host Gene Expression Changes through Primary B-Cell Outgrowth Reveals Delayed Kinetics of LMP1-Mediated NFΚB Activation.” J Virol. 86(20):11096-106.[Abstract][PDF]

Robinson, T.J., E. Forte, R.E. Salinas, S. Puri, M. Marengo, M.A. Garcia-Blanco, Luftig, M.A. (2012). “SplicerEX: A tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data.” RNA. 18(8):1435-45.[Abstract] [PDF]

Nikitin, P.A., Luftig, M.A. (2012). “The DNA damage response in viral-induced cellular transformation. Br J Cancer. 106:429-435. [Abstract] [PDF]

Skalsky, R.L., Corcoran, D.L., Gottwein, E., Frank, C.L., Kang, D., Hafner, M., Nusbaum, J.D., Feederle, R., Delecluse, H.J., Luftig, M.A., Tuschl, T., Ohler, U., Cullen, B.R. (2012). “The viral and cellular microRNA targetome in lymphoblastoid cell lines.” PLoS Pathog. 8: e1002484. [Abstract] [PDF]

Forte, E., Salinas, R., Chang, C., Zhou, T., Linnstaedt, S.D.,  Gottwein, E., Jacobs, C., Jima, D., Li, Q.J., Dave, S.S., Luftig. M.A. (2012). The Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells. J Virol. 86, 6889-6898. [Abstract] [PDF]

Forte, E., Luftig, M.A. (2011). “The role of microRNAs in Epstein-Barr virus latency and lytic reactivation.” Microbes Infect. 13:1156-1167. [Abstract] [PDF]

Nikitin, P.A, Luftig, M.A. (2011). “At a crossroads: Human DNA tumor viruses and the host DNA damage response.”  Future Virol. 6: 813-830. [Abstract] [PDF]

Nikitin, P.A., Yan, C.M., Forte, E., Bocedi, A.,  Tourigny, J.P., Hu, K.,  Guo, J., Tainter, D., Rusyn, E. and Luftig, M.A. (2010). “An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.” Cell Host Microbe. Dec 16;8(6):510-22. [Abstract] [PDF]

Linnstaedt, S.D., E. Gottwein, R.L. Skalsky, Luftig, M.A., and Cullen, B.R. (2010). “Virally induced cellular miR-155 plays a key role in B-cell immortalization by EBV.” J Virol. Nov;84(22):11670-11678. [Epub 2010 Sept 15].[Abstract] [PDF]

Forte, E. and Luftig, M.A. (2009). “MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B cell growth transformation and infected cell survival.” J Virol.(2009). 83:2491-2499. [Epub 2009 Jan 14]. [Abstract] [PDF]