Maria Cardenas-Corona, PhD – Publications

Research Professor

research • lab members • publications • alumni

Representative Publications:

Park, H.S., Lee S.C., Cardenas, M.E., Heitman, J. (2019). The calcium-calmoduline-calcineurin signaling cascade: A globally conserved eukaryotic microbial pathogen virulence cascade. Cell Hosts and Microbes, 26(4):453-462. doi: 10.1016/jchom.2019.08.004.

Son. Y.E., Ci-Fu, Jung, W.H., Oh, S.H., Kwak, J.H., Cardenas, M.E., Heitman, J. and Park, H.S. (2019) Pbp1-interacting protein Mkt1 regulates virulence and sexual reproduction in Cryptococcus neoformans. Front. Cell. Infect. Microbiol. 9:355. doi: 10.3389/fcimb.2019.00355

Son. Y.E., Jung, W.H., Oh, S.H., Kwak, J.H., Cardenas, M.E., Park, H.S. (2018) Mon1 is essential for fungal virulence and stress survival in Cryptococcus neoformans. Microbiology 46 (2): 114-121. doi: 10.1080/12298093.2018.1468053. eCollection 2018.

Fu, C., Donadio, N., Cardenas, M.E, and Heitman, J. (2018) Dissecting the roles of the calcineurin pathway in unisexual reproduction, stress responses, and virulence in Cryptococcus deneoformans. Genetics 208 (2): 639-653. doi: 10.1534/genetics.117.300422.

Jung, W.H., Son. Y.E., Oh, S.H., Fu, C., Kim, H.S., Kwak, J.H., Cardenas, M.E., Heitman, J, Park, H.S. (2018) Had1 is required for cell wall integrity and fungal virulence in Cryptococcus neoformans. G3 8 (2), 643-652. doi:10.1534/g3.117.300444. This study was featured in the cover of the issue.

  1. Liu, N-N., Flanagan, P., Zeng, J., Jani1, N., Cardenas, M.E., Moran, G.P., Köhler, J.R. (2017) Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition. Natl. Acad. Sci. USA. In press.

Chow, E.W.L., Clancey, S.A., R. Billmyre, B., Floyd, A., Granek, J.A., Mieczkowski, P., Cardenas, M.E., and Heitman, J. (2017). Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans. PLoS Genet. 13(4):e1006667.

  1. Calo, S., Nicolas, F.E., C., Lee, S.C., Vila, A., Cervantes, M., Torres-Martinez, S., Ruiz-Vazquez, R.M.,  Cardenas, E., and Heitman, J. (2017) A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutation in the human fungal pathogen Muccor circinelloides. PLoS Genet. 13(3):e1006686.

Park, H., Chow, E.W.L., Soderblom, E.J., Moseley, A., Heitman, J., and Cardenas M.E. (2016) Calcineurin targets involved in stress survival and virulence of Cryptococcus neoformasns. PLoS Pathogens 12(9):e1005873.

  1. Kingsbury, J.M., Shamaprasad, N., Billmyre, B., Heitman, J., and Cardenas M.E.   (2016) Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability. Mol. Genet. 25 (16): 3524-3538 doi: 10.1093/hmg/ddw195
  2. Kingsbury, J.M., and Cardenas M.E. (2016) Vesicular trafficking systems impact TORC1-controlled transcriptional programs in Saccharomyces cerevisiae. G3 6 (3), 641-652.

Kingsbury JM, Sen ND, Cardenas ME.  (2015) Branched-chain aminotransferases control TORC1 signaling in Saccharomyces cerevisiae.  PLoS Genet. 11:e1005714.

Xu B, Sowa N, Cardenas ME, Gerton JL. (2015) L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome.  Hum Mol Genet.  24:1540-1555.

Calo, S., Shertz-Wall, C.,  Lee, S.C., Bastidas, R.J., Nicolas, F.E., Granek, J.A., Mieczkowski, P., Torres-Martinez, S., Ruiz-Vazquez, R.M., CardenasM.E., and Heitman, J. (2014) Antifungal drug resistance evoked via RNAi-dependent epimutations. Nature 513:555-558.

Kingsbury, J. M., Sen, N. D., Heitman, J. and Cardenas, M. E. (2014). Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. Genetics 196:1077-1089.

Gioti, A., Nystedt, B., Li, W., Xu, J., Andersson, A., Averette, A.F., Munch, K., Wang, X., Kappauf, C., Kingsbury, J.M., Kraak, B., Walker, L.A., Johansson, H.J., Holm, T., Lehtio, J., Stajich, J.E., Mieczkowski, P., Kahmann, R., Kennell, J.C., Cardenas, M.E., Lundeberg, J., Saunders, C.W., Boekhout, T., Dawson, T.L., Munro, C.A., de Groot, P.W., Butler, G., Heitman, J., Scheynius, A. (2013). Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis. mBio 4:e00572-00512.

Bastidas, R.J., Shertz, C.A., Lee, S.C., Heitman, J.and Cardenas, M.E. (2012). Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloidesvia FKBP12-dependent inhibition of Tor. Euk. Cell. 11:270-281. *This study was highlighted in the April 2012 issue of the ASM magazine Microbe (vol. 7, page 186).

Shertz, C.A., and Cardenas, M.E. (2011). Exploiting and subverting Tor signaling in the pathogenesis of fungi, parasites, and viruses. PLoS Pathog. 7(9):e1002269. 

Kozubowski, L., Aboobakar, E.F., Cardenas, M.E., and Heitman, J. (2011). Calcineurin co-localizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformansEuk. Cell. 11:1396-1402.

Shertz, C.A., Bastidas, R.J., Li, W., Heitman, J., and Cardenas, M.E. (2010). Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. BMC Genomics, 11:510.

Morales-Johansson, H., Puria, R., Brautigan, D.L., and Cardenas, M.E. (2009). Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiaePLoS One, 4:e6331.

Bastidas, R.J., Heitman, J., and Cardenas, M.E. (2009). The protein kinase Tor1 regulates adhesin gene expression in Candida albicansPLoS Pathogens, 5:e1000294.

Puria, R. and Cardenas, M.E. (2008). Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiae. Communicative & Integrative Biology, 1:23-25.

Bastidas, R.J., Reedy, J.L., Morales-Johansson, H., Heitman, J., and Cardenas, M.E. (2008). Signaling cascades as drug targets in model and pathogenic fungi. Current Opinion in Investigational Drugs, 9:856-864.

Puria, R., Zurita-Martinez, S.A., and Cardenas, M.E. (2008). Nuclear translocation of Gln3 in response to nutrient signals requires Golgi to endosome trafficking in Saccharomyces cerevisiaeProc. Natl. Acad. Sci. USA,105:7194-7199.
This study was featured on the cover and highlighted by a commentary in the same PNAS issue. It was also highlighted in the editor’s choice section of Science Signaling: A.M. VanHook, Route to Specificity. Sci. Signal. 1, ec199 (2008). 

Rohde, J.R., Bastidas, R., Puria, R., and Cardenas, M.E. (2008). Nutritional control via Tor signaling in Saccharomyces cerevisiae. Current Opinion in Microbiology, 2:153-160.

Rutherford, J.C., Chua, G., Hughes, T., Cardenas, M.E., and Heitman J. (2008). A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. Molecular Biology of the Cell, 19:3028-3039.

Zurita-Martinez, S.A., Puria, R., Pan, X., Boeke, J.D., and Cardenas, M.E. (2007). Efficient Tor signaling requires a functional Class C Vps protein complex in Saccharomyces cerevisiaeGenetics, 107:2139-2150.

Bahn, Y-S., Xue, C., Idurm, A., Rutherford, J.C., Heitman, J., and Cardenas, M.E. (2007). Sensing the environment: Lessons from fungi. Nature Reviews Microbiology, 5:57-69.

Zurita-Martinez, S.A., and Cardenas, M.E. (2005). TOR and cyclic AMP-Protein Kinase A: Two parallel pathways regulating expression of genes required for cell growth. Eukaryotic Cell, 4:63-71.

Rohde, J.R., Campbell, S., Cutler, N.S., Zurita-Martinez, S.A., Ashe, M., and Cardenas, M.E. (2004). TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase effectors. Molecular Cell Biology,24:8332-8341.

Rohde, J. and Cardenas, M.E. (2003). The TOR pathway links nutrient sensing to histone acetylation. Molecular Cell Biology, 23:629-635.

Rohde, J., Heitman, J., and Cardenas, M.E. (2001). The TOR kinases link nutrient sensing to cell growth. Journal of Biological Chemistry, 276:9583-9586.

Cutler, N.S., Pan, X., Heitman, J., and Cardenas, M.E.(2001). The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Molecular Biology of the Cell, 12:4103-4113.

Cardenas, M. E., Cutler, N. S., Lorenz M.C., Di Como, C.J., and Heitman, J. (1999). The TOR signaling cascade regulates gene expression in response to nutrients.Genes and Development, 13:3271-3279.

Alarcon, C.M., Heitman, J., and Cardenas, M.E. (1999). Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Molecular Biology of the Cell, 10:2531-2546.

Cardenas, M.E., Crux, M.C., Del Poeta, M., Chung, N., Perfect, J.R., and Heitman, J. (1999). Antifungal actions of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clinical Microbiology Reviews, 12:583-611.

Cutler, N.S., Heitman, J., and Cardenas, M.E. (1999). TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. Molecular and Cellular Endocrinology, 155:135-142.