Max M. Villa, PhD
2133 CIEMAS Building
Box 3382 DUMC
Durham, NC 27710
Research Interest: Microfluidics, Microbiology
I am interested in harnessing droplet based microfluidic systems for high throughput microbiology. These tools can help us identify novel interactions that orchestrate microbial community ecology.
For my doctoral project I developed ways of using progenitor cells and biomaterials to regenerate bone in response to injury. As part of this process, I developed biomaterials and applied new imaging methods for examining cells and cell-biomaterial interactions in vivo.
During my Master’s thesis I developed microfluidic systems for growing stem cells. These devices enable exquisite control of the cell microenvironment, which can be used to understand how stem cells develop into specific tissues, and can be arranged in a high throughput format using very small volumes of fluids (microliters of culture medium per chamber).
Personal Interests: I enjoy kiteboarding, surfing, and bicycle touring. In 2009 I completed a coast-to-coast tour of the U.S. by bicycle, retracing the Bikecentennial originally done in 1976.
Villa, M.M., Wang, L., Huang, J.P., Rowe, D.W., Wei, M., “Improving the permeability of lyophilized collagen-hydroxyapatite scaffolds for cell-based bone regeneration with a gelatin porogen”, Journal of Biomedical Materials Research Part B: Applied Biomaterials, (in press).
Villa, M.M., Wang, L., Huang, J.P., Rowe, D.W., Wei, M., “Effects of cell-attachment and extracellular matrix on bone formation in vivo in collagen-hydroxyapatite scaffolds”, PLoS One, 9 (10), (2014).
Villa, M.M., Wang, L., Huang, J.P., Rowe, D.W., Wei, M., “Bone tissue engineering with a collagen-hydroxyapatite scaffold and mouse bone marrow stromal cells in a critical size calvarial defect”, Journal of Biomedical Materials Research Part B: Applied Biomaterials 103, 243-253 (2015).
Xia, Z., Villa, M.M., Wei, M., “A biomimetic collagen–apatite scaffold with a multi-level lamellar structure for bone tissue engineering”, Journal of Materials Chemistry B, 2(14), 1998-2007, 2014.
Villa, M.M., Wang, L., Huang, J.P., Rowe, D.W., Wei, M., “Visualizing Osteogenesis In Vivo within a Cell-Scaffold Construct for Bone Tissue Engineering using 2-Photon Microscopy”, Tissue Engineering: Part C 19, 839-849 (2013). (cover image)
Villa, M.M., Pope, S.E., Conover, J.C., & Fan, T.-H., “Growth of primary embryo cells in a microculture system”, Biomedical Microdevices 12, 253-261 (2010).