Shelly Clancey

Heitman – Lab Members

Headshot of Shelly ClanceyLab Research Analyst I
312 CARL Building
Box 3546 DUMC
Durham, N.C. 27710
Phone: 919.684.9702
Fax: 919.684.2790
shelly.clancey@duke.edu

Biography

I am originally from Minnesota, growing up Rochester, MN and attending college in Minneapolis, MN. I graduated from the University of Minnesota with a Bachelor’s of Science in Genetics, Cell Biology and Development and a minor in Animal Science. My love for science started in a biotechnology class, and from there, I pursued more molecular genetics based courses. During my time at the U of M, I worked in two different molecular biology labs. The first was with the Department of Animal Science where I aimed to express the human APOBEC system in an avian cell line. The second was with the Department of Genetics, Cell Biology and Development where I studied the flexibility of kinetochores and centromeres in the model organism Candida albicans, a human fungal pathogen. Additionally, I looked at the relationship between monopolin and condensin, and how monopolin works to organize highly repetitive regions of the genome. My general research interests include genome organization and how genomes evolve in response to stress.

Outside of the lab I spend my time cooking, traveling and spending time with friends and family!

Publications

Laura S Burrack, Shelly E Applen and Judith Berman. The requirement for the Dam1 complex is dependent upon the number of kinetochore proteins and microtubules. Current Biology  21(10):889-896, 2011.

Laura S Burrack, Shelly E Applen Clancey, Jeremy M Chacon, Melissa K Gardner and Judith Berman. Monopolin recruits condensin to organize centromere DNA and repetitive DNA sequences. Mol Bio Cell In Press doi:10.1091, 2013.

Phadke SS, Feretzaki M, Clancey SA, Mueller O, Heitman J. 2014. Unisexual reproduction of Cryptococcus gattii. PLoS One 9 (10), e111089.

Marianna Feretzaki, R. Blake Billmyre, Shelly Applen Clancey, Xuying Wang, and Joseph Heitman. 2015. Gene network polymorphism illuminates loss and retention of novel RNAi silencing components in the Cryptococcus pathogenic species complex. PLoS Genetics, 12(3):e1005868.

Burrack LS, Hutton HF, Matter KJ, Clancey SA, Plemmons AE, et al. 2016. Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome. PloS Genetics 12(9):e1006317.

Eve W.L. Chow, Shelly A. Clancey, R. Blake Billmyre, Anna Floyd Averette, Joshua A. Granek, Poitr Mieczkowski, Maria E. Cardenas, and Joseph Heitman. 2017 Elucidation of the Calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcusw neoformans. PloS Genetics, 13(4):e1006667.

  1. Blake Billmyre, Shelly Applen Clancey, and Joseph Heitman. 2017. Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii. eLife 6:28802.
  2. Giuseppe Ianiri, Shelly Applen Clancey, Soo Chan Lee, and Joseph Heitman. 2017. FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia. mBio 8(5):e01752-17.