Jörn Coers, PhD – Publications

Associate Professor
Director, Center for Host Microbial Interactions

research  biography • lab members • publications

Representative Publications

Google Scholar Profile

Kutsch, M., Sistemich, L., Lesser, CF., Goldberg, MB., Herrmann, C., Coers, J. Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions. EMBO J 2020 10.15252/embj.2019104926

Kohler, KM.*, Kutsch, M.*, Piro, AS.*, Wallace, G., Coers, J.$, Baber, MF.$ Evolution of a C-terminal polybasic motif modulates pathogen recognition by primate guanylate binding proteins. mBio 2020 May 19;11(3):e00340-20 PMID: 32430466 (*Authors contributed equally to this study; $Authors contributed equally to this study)

Giebel, AM., Hu, S., Rajaram, K., Finethy, R., Toh, E., Brothwell, JA., Morrison, SG., Suchland, RJ., Stein, BD., Coers, J., Morrison, RP., Nelson, DE. Genetic screen in Chlamydia muridarum reveals role for an Interferon-induced host cell death program in antimicrobial inclusions rupture. mBio 2019 Apr 9;10(2) pii: e00385-19. PMID:30967464ope

Coers, J., Brown, HM., Hwang, S., Taylor, GA. Partners in anti-crime: how IFN-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense. Current Opinion in Immunology 2018. 54:93-101. PMID: 29986303

Liu, BC., Sarhan, J., Panda, A., Muendlein, HI. Coers, J., Yamamoto, M., Isberg, RR., Poltorak, P. Constitutive-IFN maintains GBP expression required for release of bacterial components upstream of pyroptosis and anti-DNA responses. Cell Rep. 2018 Jul 3;24(1):155-168.e5. PMID: 29972777

Piro, AS., Hernandez, D., Luoma, S., Feeley, EM., Finethy, R., Yirga, A., Frickel, EM., Lesser, CF., Coers, J. Detection of cytosolic Shigella flexneri via a C-terminal triple-ariginine motif of GBP1 inhibits actin-based motility. mBio 2017 Dec 12;8(6) pii: e01979-17. PMID: 29233899

Finethy, R., Luoma, S., Orench-Rivera, N., Feeley, EM., Haldar, AK., Yamaoto, Y., Kanneganti, TD., Kuehn, MJ., Coers, J. Inflammasome activation by bacterial outer membrane vesicles requires guanylate binding proteins. mBio 2017 Oct 3;8(5). pii: e01188-17. PMID: 28974614

Feeley, EM.*, Pilla-Moffett, D.*, Zwack, EE., Piro, AS., Finethy, R., Kolb, JP, Martinez, J., Brodsky, IE., Coers, J. Galectin-3 directs antimicrobial Guanylate Binding Proteins to vacuoles furnished with bacterial secretion systems. (*Authors contributed equally to this study). Proc Natl Acad Sci U.S.A.  2017 Feb 28;114(9):E1698-E1706 PMID: 28193861

Coers, J. Sweet host revenge: galectins and GBPs join forces at broken membranes. Cell Microbiol. 2017 Dec;19(12). doi: 10.1111/cmi.12793. PMID: 28973783

Sixt, BS., Bastidas, RJ., Finethy, R., Baxter, RM., Carpenter, VK., Kroemer, G., Coers, J., Valdivia, RH. The Chlamydia trachomatis inclusion membrane protein CpoS counteracts cellular surveillance and suicide programs. Cell Host and Microbe 2017 Jan 11;21(1):113-121.  PMID: 28041929.

Zwack, EE., Feeley, EM., Bliska, JB., Yamamoto, M., Coers, J., Brodsky, IE. Guanylate Binding Proteins regulate inflammasome activation in response to Yersinia Type III translocon proteins. Infection and Immunity 2017 Sep 20;85(10). pii: e00778-16. PMID: 28784930

Haldar, AK., Piro, AS., Finethy, R., Espenschied, ST., Brown, HE., Giebel, AM., Frickel, E-A., Nelson, DE., Coers, J. Chlamydia trachomatis is resistant to inclusion ubiquitination and associated host defense in IFNg-primed human cells. mBio 2016. Dec 13;7(6). pii: e01417-16.  PMID: 27965446

Pilla-Moffett, D., Barber, MF., Taylor, GA., Coers, J. IFN-inducible GTPases in host defense, inflammation and disease. Journal of Molecular Biology 2016 May 12. pii: S0022-2836(16)30142-5.  PMID: 27181197

Coers, J., Finethy, R. Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis FEMS Microbiology Review 2016 Jul 29. pii: fuw027.  PMID: 27476078

Finethy, R., Jorgensen, I., Haldar, AK., de Zoete, MR., Flavell, RA., Yamamoto, M., Nagarajan, UM., Miao, EA., Coers, J. Guanylate Binding Proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. Infection and Immunity 2015 Dec; 83(12):4740-9.  PMID: 26416908; PMC4645370.

Selected by I&I editors as article of significant interest. See Research Spotlight: Infection and Immunity 83(12): 4465

Haldar, AK., Finethy, R., Piro, AS., Feeley, EM., Pilla-Moffett, D., Foltz, C., Komatsu, M., Frickel, EM., Coers, J. Ubiquitin systems mark pathogen-containing vacuoles for host defense by Guanylate Binding Proteins. Proc Natl Acad Sci U.S.A.  2015 Oct 13;112(41):E5628-37.  PMID: 26417105; PMC4611635.

FACULTY OF 1OOO: recommended article

NSF DISCOVERY FILES RADIO SPOT: http://news.science360.gov/archives/20151209

 Aachoui, Y., Kajiwara, Y., Leaf, IA., Mao, D., Ting, JP., Coers, J., Aderem, A., Buxbaum, JD., Miao, EA. Canonical inflammasomes prime murine caspase-11, but not human caspase-4 during cytosol-invasive bacterial infection. Cell Host and Microbe 2015 Sep 9;18(3):320-32.  PMID: 26320999;

Pilla, D., Hagar, JA., Haldar, AK., Mason, AK., Ernst, RK., Yamamoto M., Miao, EA., Coers, J. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U.S.A.  2014 Apr 22;111(16):6046-51.  PMID: 24715728

Haldar, AK., Saka, HA., Piro, AS., Dunn, JD., Henry, SC., Taylor, GA., Frickel, EM., Valdivia,RH., Coers, JC. IRG and GBP host resistance factors target aberrant, “non-self” vacuoles characterized by the missing of “self” IRGM proteins. PLoS Pathogens 2013 Jun;9(6):e1003414.  PMID: 23785284