Sriram Vijayraghavan, PhD
DUMC Box 3020
241 Jones Building
Durham, NC 27710
Research Interest: Research Interest: My research is based on the genetic analysis of quantitative traits in the yeast Saccharomyces cerevisiae. Our lab has sequenced and fully annotated the genomes of over 100 yeast strains that include clinical isolates and multiple non-clinical isolates from diverse geographical locations. My work focuses on analyzing phenotypic variations among these strains under varied growth conditions by high-throughput methods. The current work is aimed at elucidating how discrete genetic changes underlying complex traits influence fitness in challenging environments. Additionally, our work has implications for human health, as the availability of genome-wide phenotype-genotype association data allows us to test the emergence of yeast as an opportunistic pathogen.
Personal Interests: Along with my wife, I greatly enjoy hiking the various state parks in North Carolina.
Vijayraghavan S, Kantor B. J Vis Exp. 2017 Dec 12;(130). doi: 10.3791/56915.
Vijayraghavan S. J Mol Biol. 2017 Jul 7;429(14):2124-2126. doi: 10.1016/j.jmb.2017.05.002. Epub 2017 May 5. No abstract available.
Vijayraghavan S, Tsai FL, Schwacha A. PLoS Genet. 2016 Aug 24;12(8):e1006277. doi: 10.1371/journal.pgen.1006277. eCollection 2016 Aug.
Tsai FL, Vijayraghavan S, Prinz J, MacAlpine HK, MacAlpine DM, Schwacha A. Mol Cell Biol. 2015 Jun;35(12):2131-43. doi: 10.1128/MCB.01357-14. Epub 2015 Apr 13.
Vijayraghavan S, Schwacha A. Subcell Biochem. 2012;62:113-34. doi: 10.1007/978-94-007-4572-8_7. Review.