Elwood Linney, PhD – Publications


research • biography • lab members • publications

Representative Publications:

Roy N.M., Arpie B., Lugo J., Linney E., Levin E.D., Cerutti D. (2012). Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicol Teratol. Nov-Dec;34(6):587-91. [Epub 2012 Aug 7].

Yen J., Donerly S., Levin E.D., Linney E. (2011).Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol. Nov-Dec;33(6):735-41. [Epub 2011 Oct 19].

Linney E., Donerly S., Mackey L., Dobbs-McAuliffe B. (2011). The negative side of retinoic acid receptors. Neurotoxicol Teratol. Nov-Dec;33(6):631-40. [Epub 2011 Jul 13]. Review.

Linney E., Perz-Edwards A., Kelley B. (2011).Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Gene. Oct 15;486(1-2):31-6. [Epub 2011 Jul 13].

Sledge D., Yen J., Morton T., Dishaw L., Petro A., Donerly S., Linney E., Levin E.D. (2011). Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicol Teratol. Nov-Dec;33(6):742-51. [Epub 2011 Jul 2].

Levin E.D., Sledge D., Roach S., Petro A., Donerly S., Linney E. (2011). Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicol Teratol. Nov-Dec;33(6):668-73. [Epub 2011 Jul 7].

Alexeyenko A., Wassenberg D.M., Lobenhofer E.K., Yen J., Linney E., Sonnhammer E.L., Meyer J.N. (2010). Dynamic zebrafish ineractome reveals transcriptional mechanisms of dioxin toxicity. PLoS One. 5:e10465.

Aschner M., Levin E.D., Sunol C., Olopade J.O., Helmcke K.J., Avila D.S., Sledge D., Ali R.H., Upchurch L., Donerly S., Linney E., Forsby A., Ponnuru P., Connor J.R. (2010). Gene-environment interactions: Neurodegeneration in non-mammals and mamals. Neurotoxicology. 2010 Mar 30. [Epub ahead of print]

Powers C.M., Yen J., Linney E., Seidler F.J., Slotkin T.A. (2010). Silver exposure in developing zebrafish (Danio rerio): Persistent effects on larval behavior and survival. Neurotoxicol Teratol. 32:391-397. [Epub 2010 Jan 29]

Eddins D., Cerutti D., Williams P., Linney E., Levin E.D. (2010). Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: Comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicol Teratol. 32(1):99-108. [Epub 2009 Mar 4].

Levin E.D., Aschner M., Heberlein U., Ruden D., Welsh-Bohmer K.A., Bartlett S., Berger K., Chen L., Corl A.B., Eddins D., French R., Hayden K.M., Helmcke K., Hirsch H.V., Linney E., Lnenicka G., Page G.P., Possidente D., Possidente B., Kirshner A. (2009). Genetic aspects of behavioral neurotoxicology. Neurotoxicology. 30:741-753. [Epub 2009 Jul 30].

Timme-Laragy A.R., Van Tiem L.A., Linney E.A., Di Giulio R.T. (2009). Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicol Sci. 109:217-227. [Epub 2009 Feb 20].

Hu P., Tian M., Bao J., Xing G., Gu X., Gao X., Linney E., Zhao Q. (2008). Retinoid regulation of the zebrafish cyp26a1 promoter. Dev Dyn. 237:3798-3808.

Lassiter C.S., and Linney E. (2007). Embryonic expression and steroid regualtion of brain aromatase cyp19a1b in zebrafish (Danio rerio). Zebrafish 4:49-57.

Malone M.H., Sciaky N., Stalheim L., Hahn K.M., Linney E., and Johnson G.L. (2007). Laser-scanning velocimetry: A confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnol 7:40.

Beyer R.P., Fry R.C., Lasarev M.R., McConnachie L.A., Meira L.B., Palmer V.S., Powell C.L., Ross P.K., Bammler T.K., Bradford B.U., Cranson A.B., Cunningham M.L., Fannin R.D., Higgins G.M., Hurban P., Kayton R.J., Kerr K.F., Kosyk O., Lobenhofer E.K., Sieber S.O., vliet P.A., Weis B.K., Wolfinger R., Woods C.G., Freedman J.H., Linnery E., Kaufmann, W.K., Kavanagh T.J., Paules R.S., Rusyn I., Samson L.D., Spencer P.S., Suk W., Tennant R.J., Zarbl H.; Members of the Toxicogenomics Research Consortium. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99:326-327. [Epub 2007 Jun 11].

Kim M.J., Liu I.H., Song Y., Lee J.A., Halfter W., Balice-Gordon R.J., Linney E., Cole G.J. (2007). Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Glycobiology 17:231-247.

Deak K.L., Dickerson M.E., Linney E., Enterline D.S., George T.M., Melvin E.C., Graham F.L., Siegel D.G., Hammock P., Mehltretter L., Bassuk A.G., Kessler J.A., Gilbert J.R., Speer M.C; NTD Collaborative Group. (2005). Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth Defects Res A Clin Mol Teratol 73:868:875.

Deak K.L., Boyles A.L., Etchevers H.C., Melvin E.C., Siegel D.G., Graham F.L., Slifer S.H., Enterline D.S., George T.M., Vekemans M., McClay D., Bassuk A.G., Kessler J.A., Linney E., gilbert J.R., and Speer M.C. SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects. Hum Genet 117:133-142. [Epub 2005 May 1].

Zhao Q., Dobbs-McAuliffe B., and Linney E. (2005). Expression of cyp26b1 during zebrafish early development. Gene Expr Patterns 5:363-369.

Linney E., Dobbs-McAuliffe B., Sajadi H., Malek R.L. (2004). Microarray gene expression profiling during the segmentation phase of zebrafish development. Comp Biochem Physiol C Toxicol Pharmacol 138:351-362.

Levin E.D., Swain H.A., Donerly S., and Linney E. (2004). Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicol Teratol 26:719-723.

Linney E., Upchurch L., and Donerly S. (2004). Zebrafish as a neurotoxicological model. Neurotoxicol Teratol 26:709-718. Erratum in: Neurotoxicol Teratol (2005) 27:175.

Schwartz D.A., Freedman J.H., and Linney E.A. (2004). Environmental genomics: a key to understanding biology, pathophysiology and disease. Hum Mol Genet 2:R217-224.

Dobbs-McAuliffe B., Zhao Q., and Linney E. (2004). Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. Mech Dev 121:339-350.

Linney E., and Udvadia A.J. (2004). Construction and detection of fluorescent, germline transgenic zebrafish. Methods Mol Biol 254:271-288.

Udvadia A.J. and Linney E. (2003). Windows into Development: Historic, Current and Future Perspectives on Transgenic Zebrafish. Developmental Biology 256:1-17.

Levin E. D., Crysthansis E., Yacisin K., and Linney, E. (2003). Chlorpyrifos exposure of developing zebrafish: Effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicology and Teratology 5527:1-7.

McDermott N. B., Gordon D. F., Kramer C. A., Liu Q., Linney E., Wood W. M., and Haugen B. R. (2002). Isolation and functional analysis of the mouse RXRgamma1 gene promoter in anterior pituitary cells. J. Biolo. Chem. 277:36839-44.

Perz-Edwards A., Hardison N. L., and Linney E. (2001). Retinoic acid-mediated gene expression in transgenic reporter zebrafish. Developmental Biology 28:89-101.

Linney E., Hardison NL., Lonze B. E., Lyons S., and DiNapoli L. (1999). Transgene expression in zebrafish: A comparison of retroviral-vector and DNA-injection approaches. Developmental Biology 213(1):207-16.

Linney E., Underhill T.M., and Kotch L. (1995). Retinoids and mouse embryos. In Vitamins and Hormones, vol. 51, pp. 403-457. edited by G. Litwack. Academic Press(New York).

Smith B., Johnson G.A., Groman E. and Linney E. (1994). Magnetic resonance microscopy of mouse embryos. Proc. Natl. Acad. Sci. USA. 91 3530-3533.