Dennis Ko, MD, PhD – Publications

Assistant Professor

research • biography • lab members • publications • data and analysis tools

Representative Publications:
Alvarez MI, Glover LC, Luo P, Wang L, Theusch E, Oehlers SH, Walton EM, Tram TTB, Kuang YL, Rotter JI, McClean CM, Chinh NT, Medina MW, Tobin DM, Dunstan SJ, and Ko DC. (2017) Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1706070114. PubMed PMID: 28827342.

Wang L, Ko ER, Gilchrist J, Pittman KJ, Rautanen A, Pirinen M, Thompson JW, Dubois LG, Langley RG, Jaslow SL, Salinas RE, Rouse DC, Moseley A, Mwarumba S, Njuguna P, Mturi N, Wellcome Trust Case-Control Consortium 2, The Kenyan Bacteraemia Study Group, Williams TN, Scott AG, Hill AVS, Woods CW, Ginsburg GS, Tsalik EL and Ko DC. (2017) Human genetic and metabolite variation reveal methylthioadenosine is a prognostic biomarker and inflammatory regulator in sepsis. Science Advances. 3(3):e1602096.

Galarza-Muñoz G, Briggs FBS, Evsyukova I, Bergamaschi L, Wang L, Ko DC, Bradrick SS, Barcellos LF, Garcia-Blanco MA, and Gregory SG. (2017) The RNA helicase DDX39B regulates IL7R splicing reducing the risk of Multiple Sclerosis. Cell. 169(1):72-84.e13.

Pittman KJ, Glover LC, Wang L, and Ko DC. (2016) The Legacy of Past Pandemics: Common Human Mutations that Protect Against Infectious Disease. PLoS Pathogens. 12(7):e1005680.

Oehlers SH, Flores MV, Hall CJ, Wang L, Ko DC, Crosier KE, Crosier PS.(2016) A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.  FEBS J. doi:10.1111/febs.13976 [Epub ahead of print].

Wang L, Oehlers SH, Espenschied ST, Rawls JF., Tobin DM, and Ko DC. (2015) CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation. Genome Biology. 16:190.

Salinas RE, Ogohara C, Shukla KP, Thomas MI, Miller SI, and Ko DC. (2014) A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death. Mol Biol Cell. 25(1):76-86.

Ko DC, Urban TJ. (2013) Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS. PLoS Pathogens. 9(8):e1003424.

Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI. (2012) Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. PNAS. 109:E2343-2352.

Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Dunstan S, Farrar JJ, Thwaites G, King MC, Serhan CN, Ramakrishnan L. (2012) Therapies directed to LTA4H genotype can optimize the inflammatory response to mycobacterial infections. Cell. 148(3):434-46.

Fong C, Ko DC, Wasnick M, Radey M, Miller SI, Brittnacher M. (2010) GWAS Analyzer: integrating genotype, phenotype and public annotation data for genome-wide association study analysis. Bioinformatics. 26(4):560-4.

Ko DC, Shukla KP, Fong C, Wasnick M, Brittnacher MJ, Wurfel MM, Holden TD, O’Keefe GE, Van Yserloo B, Akey JM, Miller SI. (2009) A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. Am J Hum Genet. 85(2):214-27.

Ko DC, Milenkovic L, Beier S,  Manuel H, Buchanan J, Scott MP. (2005) Cell-autonomous death of cerebellar Purkinje neurons with autophagy in Niemann-Pick type C disease. PLoS Genetics. 1(1):e7.

Ko DC, Binkley J, Sidow A, Scott MP. (2003) The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. Proc Natl Acad Sci U S A. 100(5):2518-25.

Ko DC, Gordon MD, Jin JY, Scott MP. (2001) Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. Mol Biol Cell. 12(3):601-14.

For a complete list of publications, click here.