Louis-Jan Pilaz, PhD
223 CARL Building
Box 3175 DUMC
Durham, N.C. 27710
During the development of the mammalian cortex, the precise regulation of the cell-cycle in neural stem cells/progenitors is crucial. My PhD work focused on the importance of the regulation of the G1 phase of the cell-cycle during mouse corticogenesis. In the Silver lab, I am currently studying the regulation of the mitotic phase in the context of cortical development, and more specifically, the importance of the exon-exon junction complex in that process. I am using a variety of tools such as immunohistochemistry, in utero electroporation and live imaging on organotypic brain slices.
Markov NT, Misery P, Falchier A, Lamy C, Vezoli J, Quilodran R, Gariel MA, Giroud P, Ercsey-Ravasz M, Pilaz LJ, Huissoud C, Barone P, Dehay C, Toroczkai Z, Van Essen DC, Kennedy H, Knoblauch K. Weight consistency specifies regularities of macaque cortical networks. Cereb Cortex. 2011 Jun;21(6):1254-72. [Epub 2010 Nov 2].
Pilaz LJ, Patti D, Marcy G, Ollier E, Pfister S, Douglas RJ, Betizeau M, Gautier E, Cortay V, Doerflinger N, Kennedy H, Dehay C.Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21924-9.