Charlie Pyle, PhD
218 Jones Building
DUMC Box 3020
Durham, NC 27710
Phone: (919) 668-9234
Fax: (919) 684-2790
Research Interest: Innate immunity, Host-directed therapy, Microbial pathogenesis
I graduated from the Ohio State University with a PharmD, where I then went on to earn a PhD in the lab of Larry Schlesinger investigating the impact of human zinc metabolism on macrophage inflammation and host-resistance to Mycobacterium tuberculosis. In the Tobin lab my work focuses on investigation of tuberculosis pathogenesis. I use a number of unique model systems to evaluate host genetic factors that govern the immune response within mycobacterial granulomas in an effort to discover novel immunomodulatory mechanisms for host-directed therapy.
Personal Interests: Click here to enter text.
I spend most of my time outside of the lab trying to keep up with my two rambunctious daughters on journeys through North Carolina. For leisure I enjoy outdoor recreation, good conversation and discovering the works of talented artists, musicians, authors, chefs and the like.
Pyle CJ, Akhter S, Bao SY, Dodd CE, Schlesinger LS, Knoell DL. Zinc Modulates Endotoxin-Induced Human Macrophage Inflammation through ZIP8 Induction and C/EBPβ Inhibition. PLoS One. 2017 Jan 5;12(1):e0169531.
Dodd CE, Pyle CJ, Glowinski R, Rajaram MVS, Schlesinger LS. CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis. J. Immunol. 2016 Dec 15;197(12):4727-4735.
Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL. ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB. Cell Rep. 2013 Feb 21;3(2):386-400.