Charlie Pyle, PhD

Tobin – Lab members

Headshot of Charlie Pyle, PhDPostdoctoral Associate
218 Jones Building
DUMC Box 3020
Durham, NC 27710
Phone: (919) 668-9234
Fax: (919) 684-2790
charlie.pyle@duke.edu

Research Interest: Innate immunity, Host-directed therapy, Microbial pathogenesis

I graduated from the Ohio State University with a PharmD, where I then went on to earn a PhD in the lab of Larry Schlesinger investigating the impact of human zinc metabolism on macrophage inflammation and host-resistance to Mycobacterium tuberculosis. In the Tobin lab my work focuses on investigation of tuberculosis pathogenesis. I use a number of unique model systems to evaluate host genetic factors that govern the immune response within mycobacterial granulomas in an effort to discover novel immunomodulatory mechanisms for host-directed therapy.

Personal Interests: Click here to enter text.

I spend most of my time outside of the lab trying to keep up with my two rambunctious daughters on journeys through North Carolina. For leisure I enjoy outdoor recreation, good conversation and discovering the works of talented artists, musicians, authors, chefs and the like.

Publications List:

Pyle CJ, Akhter S, Bao SY, Dodd CE, Schlesinger LS, Knoell DL. Zinc Modulates Endotoxin-Induced Human Macrophage Inflammation through ZIP8 Induction and C/EBPβ Inhibition. PLoS One. 2017 Jan 5;12(1):e0169531.

Dodd CE, Pyle CJ, Glowinski R, Rajaram MVS, Schlesinger LS. CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis. J. Immunol. 2016 Dec 15;197(12):4727-4735.

Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL. ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB. Cell Rep. 2013 Feb 21;3(2):386-400.