David J. Pickup, PhD – Publications

Emeritus Associate Professor

research • biography • publications

Representative Publications:

Ray, C. A., Black, R. A., Kronheim, S. R., Greenstreet, T. A., Sleath, P. R., Salvesen, G. S. and Pickup, D.J. (1992). Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1b converting enzyme. Cell. 69:597-604.

Hu, F.-Q., Smith, C. A., and Pickup, D. J. (1994). Cowpox virus contains two copies of an early gene encoding a soluble, secreted form of the Type II TNF receptor. Virology. 204:343-356.

Smith, C. A., Hu, F.-Q., Davis-Smith, T, Richards, C.L., Smolak, P., Goodwin, R. G., and Pickup, D. J. (1996). Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LTa. Virology. 223:132-147.

Loparev, V.N., Parsons, J.M., Knight, J.C., Fanelli Panus, J., Ray, C.A., Buller, R.M.L., Pickup, D.J., and Esposito, J.J. (1998). A third distinct tumor necrosis factor receptor of orthopoxviruses. Proc. Natl. Acad. Sci. USA. 95:3786-3791.

Oie, K.L. and Pickup, D.J. (2001). Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of the activation of NF-kB. Virology. 288:175-187.

Fanelli Panus, J., Smith, C.S., Ray, c.A., Davis Smith, T., Ptael, D.D., and Pickup, D.J. (2002). Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue. Proc. Natl. Acad. Sci. USA. 99:8348-8353.

McKelvey, T.A., Andrews, S.A., Miller, S.E., Ray, C.A., and Pickup, D.J. (2002). Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions. J. Virology. 76:11216-11225.

D’Costa, S.M., Antczak, J.B., Pickup, D.J., and Condit, R.C. (2004). Post-transcription cleavage generates the 3′ end of F17R transcripts in vaccinia virus. Virology. 319:1-11.

Thornburg, N.J., Ray, C.A., Collier, M.L., Liao, H.X., Pickup, D.J. and Johnston, R.E. (2007). Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Virology. 362:441-452.

Pickup, D.J. (2007). Understanding orthopoxvirus interference with host immune responses to inform novel vaccine design. Expert Rev Vaccines. 6:87-95.

Lynch, H.E., Ray, C.A., Oie, K.L., Pollara, J.J., Petty, I.T., Sadler, A.J., Williams, B.R., and Pickup, D.J. (2009). Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication. Virology. 391:177-186.

Byun, M., Verweij, M.C., Pickup, D.J., Wiertz, E.J., Hansen, T.H., and Yokoyama, W.M. (2009). Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells. Cell Host Microbe. 19:422-432.

Pickup, D.J. (2010). Perspective: Propelling Progeny. Science. 327:787-788.

Hansen, S.J., Rushton, J., Dekonenko, E.P., Chand, H.S., Olson, G.K., Hutt, J.A., Pickup, D.J., Lyons, C.R., and Lipscomb, M.F. (2011). Cowpox virus inhibits human dendritic cell function by non-lethal, non-productive infection. Virology. 412:411-425.

Spesock, A.H., Barefoot, B.E., Ray, C.A., Kenan, D.J., Gunn, M.D., Ramsburg, E.A., and Pickup, D.J. (2011). Cowpox virus induces interleukin-10 both in vitro and in vivoVirology 417(1):87–97.

Pollara, J.J., Spesock, A.H., Pickup, D.J., Laster, S.M., and Petty, I.T. (2012). Production of prostaglandin E2 in response to infection with modified Vaccinia Ankara virus. Virology. 428(2):146-155 [Epub 2012 Apr 23].

Fouda, G. G. A., Amos, J. D., Wilks, A. B., Pollara, J., Ray, C. A., Chand, A., Kunz, E.L., Liebl, B.E., Whitaker, K., Carville, A., Smith, S., Colvin, L., Pickup, D.J., Staats, H.F., Overman, G., Eutsey-Lloyd, K., Parks, R., Chen, H., Labranche, C., Barnett, S., Tomaras, G.D., Ferrari, G., Montefiori, D.C., Liao, HX., Letvin N.L., Haynes, B.F., Permar, S.R. (2013). Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 Envelope induces strong Env-specific IgA antibody responses in breast milk. Journal of Virology. 87:146-155.

Alzhanova, D., Hammarlund, E., Reed, J., Meermeier, E., Rawlings, S., Ray, C.A., Edwards, D., Bimber, B., Legasse, A., Planer, S., Sprague, J., Axthelm, M.K., Pickup D.J., Lewinsohn, D.M., Gold M.C., Wong S.W., Sacha J.B., Slifka M.K., and Früh, K. (2014). T cell inactivation by poxviral B22R family proteins increases viral virulence. PLoS Pathogens. 10(5):e1004123.

Pickup, D. J. (2015) Poxviruses. In: Encyclopedia of Life Sciences (eLS). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0001083.pub3

Pickup, D.J. (2015). Extracellular Virions: The Advance Guard of Poxvirus Infections. PLoS Pathogens, 11(7), e1004904. doi:10.1371/journal.ppat.1004904.

Nelson C.S., Pollara J., Kunz E.L., Jeffries T.L. Jr, Duffy R., Beck C., Stamper L., Wang M., Shen X., Pickup D.J., Staats H.F., Hudgens M.G., Kepler T.B., Montefiori D.C., Moody M.A., Tomaras G.D., Liao H.-X., Haynes B.F., Ferrari G., Fouda G.G., and Permar S.R. (2016) Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces Robust IgA-Isotype B Cell Response in Breast Milk. J Virol. Apr 29;90(10):4951-65. doi.org/10.1128/JVI.00335-16   PMID: 26937027

Jones D.I., McGee C.E., Sample C.J., Sempowski G.D., Pickup D.J., Staats H. (2016) Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge. Clin Vaccine Immunol. 2016 Jul 5;23(7):648-51.

Phillips B., Fouda G.G., Eudailey J., Pollara J., Curtis A.D. 2nd, Kunz E., Dennis M.,
Shen X., Bay C., Hudgens M., Pickup D., Alam S.M., Ardeshir A., Kozlowski P.A., Van Rompay
K.K.A., Ferrari G., Moody M.A., Permar S., De Paris K. (2017) Impact of Poxvirus Vector
Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120
Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. Clin. Vaccine
Immunol. 2017 Oct 5;24(10). pii: e00231-17. doi: 10.1128/CVI.00231-17. PMCID: PMC5629672.

Eudailey J., Dennis M., Parker M., Phillips B., Huffman T., Bay C., Hudgens M., Wiseman R., Pollara J., Fouda G.G., Ferrari G., Pickup D., Kozlowski P., Van Rompay K., De Paris K., and Permar S. Maternal HIV-1 Env vaccination for systemic and breast milk immunity to prevent oral SHIV acquisition in infant macaques (2017) In press, mSphere.