Host-Microbial Interactions

The Center for Host-Microbial Interactions (CHoMI) provides an interdepartmental intellectual home for Duke investigators who are interested in this broad area of research. CHoMI was originally conceived as the Center for Microbial Pathogenesis, which was designed to build on the success of the mycology group at Duke and strengthen bacterial pathogenesis initiatives at our institution. Following the successful recruitment of new faculty, the Center has evolved into a community of 40 laboratories spanning a number of departments and divisions that are focused on the study of various unique aspects of host-microbial interactions.

Specific areas of research and expertise within the CHoMI community include:

  • Model hosts to study host-microbial interactions
  • Infectious complications in immunocompromised hosts
  • Mechanisms of microbial pathogenesis using the tools of fungal and bacterial genetics
  • Genomic technology to address microbial pathogenesis
  • Immune responses triggered by pathogen-associated molecular patterns
  • Population biology of microbes
  • Virus-host interactions
  • Microbiome influence on susceptibility to infections, host physiology, and disease
  • Human genetic basis for determinants of susceptibility to infections and inflammatory disorders
  • Host-pathogen interactions via bacterial vesicle production
  • Characterization of novel virulence factors

[Please visit our Faculty page for detailed information regarding individual research programs and laboratory websites. Visit our History page to learn more about the center.]

The overall goals of the Center for Host-Microbial interactions (CHoMI) are to provide members with:

  • A supportive and interactive atmosphere where colleagues with common interests in host-pathogen interactions can interact and collaborate.
  • A robust training environment for graduate students, post-doctoral fellows, medical students, and medical fellows with an interest in training in the field.
  • An environment for recruiting future outstanding faculty to Duke University Medical Center to join us in our quest to understand the molecular nature of the host-pathogen interaction and develop the means to intercede for therapy.