Alex Wells

Coyne – Lab Members

Visiting Grad Student
MSRB 3, Floor 3, Bay 23
Durham, NC 27710
alexandra.wells@duke.edu

 

 

Research Interests:
I graduated from Bucknell University in 2015 with a BS in Biology. Follow graduation, I was post-baccalaureate researcher with Kathy Zoon at the NIH for 2 years. While in Dr. Zoon’s lab, I focused on the characterization of a new interferon stimulated gene that had antiviral properties against dengue virus.  My research interests are focused on how viruses evade the innate immune response and how the host over comes these evasion mechanisms. I am particularly interested in how RNA viruses evade immune response with such a small genome. My current training in Dr. Coyne’s laboratory is focused on defining the mechanisms which enteroviruses infect the gastrointestinal tract and the mechanisms these viruses evade the host response to disseminate to secondary tissues and cause disease.

Publications:

Culler Freeman M, Wells AI, Ciomperlik-Patton J, Myerburg MM, Anstadt J, Coyne CB. Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates. eLife. 2021 Jul 1. PMID: 34196272.

Wells AI, Grimes KA, Kim K, Branche E, Bakkenist CJ, DePas WH, Shresta S, Coyne CB. Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice. PLOS Pathogens. 2021 Jan 29;17(1):e1009252. PMID: 33513208.

Good C, Wells AI, Coyne CB. Type III interferon signaling restricts Enterovirus 71 infection of goblet cells. Science Advances. 2019 March 6; 5(3): eaau4255. PMID: 30854425.

Morosky S*, Wells AI*, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB. The neonatal Fc receptor is a pan-echovirus receptor. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3758-3763. Epub 2019 Feb 11. PMID: 30808762. (*Authors contributed equally).

Wells AI, Coyne CB. Uterine NK cell education: Learning the ropes in pregnancy. Immunity. 2021 June 8. 54. Preview. PMID: 34107267.

Wells AI, Coyne CB. Inhibiting Ebola virus and SARS-CoV-2 entry. Science. 2020 October 9; 370(6513). Perspective. PMID: 33033203.

Wells AI, Coyne CB. Enteroviruses: a gut-wrenching game of entry, detection and evasion. Viruses. 2019 May 21; 11(460). doi:10.3390/v11050460. Review. PMID: 31117206.