Duke University Medical Center
Faculty and Research

Heitman Lab Members

Sheng Sun
Post-Doctoral Fellow

320 CARL Building
Box 3546 DUMC
Durham, N.C. 27710

Phone: 919.684.3036
Fax: 919.684.5458
Email: sheng.sun@duke.edu

Sheng Sun

My research mainly focuses on 1) the evolution of mating type locus (MAT) in fungi, with emphasis on Cryptococcus neoformans and its closely related species; 2) meiotic recombination during same-sex and opposite-sex mating in Cryptococcus neoformans, and 3) uniparental mitochondrial inheritance in Cryptococcus amylolentus and Cryptococcus neoformans, the mechanisms and the evolutionary consequences.


*Lee, Soo Chan, *S. Sun and J. Heitman. 2013 Unseen sex in ancient virgin fungi. New Phytologist 201:3-5. (Commentary)
Equal Contribution

James TY, S. Sun, W. Li, J. Heitman, H-C Kuo, Y-H Lee, Asiegbu FO and A. Olson. 2013 Polyporales genomes reveal the genetic architecture underlying tetrapolar and bipolar mating systems. Mycologia 105:1374-1390.

* Sun, S., § F. Hagen, § J. Xu, T. Dawson, J. Heitman, J. Kronstad, C. Saunders and T. Boekhout. 2013 Ecogenomics of human and animal basidiomycetous yeast pathogens (BYP). In: Ecological Genomics of the Fungi
Equal Contribution

Heitman, J., S. Sun and TY James. 2013 Evolution of fungal sexual reproduction. Mycologia 105:1-27.

Lee, Soo Chan, S. Phadke, S. Sun and J. Heitman. 2012 Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases. Eukaryotic Cell 11:1391-1398.

Sun, S. and J. Heitman. 2012 Should Y stay or should Y go: the evolution of non-recombining sex chromosomes. Bioessays 34:938-942.

Wang, X, P. Wang, S. Sun, S. Darwiche, A. Idnurm and J. Heitman. 2012 Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans. PLoS Genetics 8:e1002885.

Sun, S., Y-P. Hsueh and J. Heitman. 2012 Gene conversion occurs within the mating-type locus of Cryptococcus neoformans during sexual reproduction. PLoS Genetics 8:e1002810.

Floudas, D., M. Binder, R. Riley, K. Barry, R.A. Blanchette, B. Henrissat, A.T. Martínez, R. Otillar, J.W. Spatafora, J.S. Yadav, et al. 2012 The paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science 336:1715-1719.

Wang, X., W. Li, S. Sun, L. Kozubowski, S. Lee, M. Feretzaki and J. Heitman. 2012 Know your enemy: how to build and vanquish a global fungal scourge. Mycopathologia, 173:295-301.

* Findley, F., § Sun, S., J.A. Fraser, Y-P. Hsueh, A. F. Averette, W. Li, F. S. Dietrich and J. Heitman. 2012 Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex. PLoS Genetics 8: e1002528.
Equal Contribution

Min, N., M. Feretzaki, S. Sun, X. Wang and J. Heitman. 2011 Sex in Fungi. Annual Reviews in Genetics 45:405-431.

Sun, S., B. Metin, K. Findley, A. Fonseca and J. Heitman. 2011 Validation of Kwoniella heveanensis, teleomorph of the basidiomycetous yeast Cryptococcus heveanensis. Mycotaxon 116:227–229.

Sun, S. and J. Heitman. 2011 Is sex necessary? BMC Biology 9:56.

Rodriguez-Carres, M., K. Findley, S. Sun, F.S. Dietrich and J. Heitman, 2010 Morphological and genomic characterization of Filobasidiella depauperata: A homothallic sibling species of the pathogenic Cryptococcus species complex. PLoS ONE 5:e9620.

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