Duke University Medical Center
Faculty and Research

Heitman Lab Members

Nachi Shamaprasad
Undergraduate Student

312 CARL Building
Box 3546 DUMC
Durham, N.C. 27710

Phone: 919.684.9702
Fax: 919.684.5458
Email: nks10@duke.edu

Nachi Shamaprasad

I am currently an undergraduate student in the Trinity College of Arts and Sciences, class of 2015. I am a biology major, and am also pursuing a certificate in Genome Sciences and Policy as well as a computational biology minor. I work in the Heitman lab with Dr. Joanne Kingsbury. The goal of my project is to profile the effects of a gain-of-function mutation in the isocitrate dehydrogenase enzyme that results in production of 2-hydroxy-glutarate (2HG). This mutation is common in glioma tumors. We are using a S. cerevisiae model of the mutation to elucidate the effects of 2HG on DNA stability and on metabolism.


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