Faculty and Research
Heitman Lab Members
315 CARL Bldg
Box 3546 DUMC
Durham, N.C. 27710
Phone: (919) 684-2809
Fax: (816) 684-5458
I am an undergraduate in the Pratt School of Engineering, class of 2015, and am pursuing a degree in biomedical engineering with a minor in Spanish. Since starting at the lab in 2012, I have worked on a variety of projects. For a year and a half, I worked with Dr. Joseph Ying-Lien Chen, investigating thermotolerance and virulence in a variety of projects involving the Cryptococcus and Candidaspecies. More recently, my work has focused on characterization of novel drug combinations to investigate synergistic antifungal effects in in vitro models as well as in in vivo murine models. I am currently working on characterizing the Candida glabrata calcineurin pathway to investigate its role in virulence and as a potential novel drug target.
Chen Y.L., Yu S.J., Huang H.Y., Chang Y.L., Lehman V.N., Silao F.G., Bigol U.G., Bungay A.A., Averette A., Heitman J. Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis. Eukaryot Cell. 2014 Jul;13(7):844-54. doi: 10.1128/EC.00302-13. [Epub 2014 Jan 17].
Chen, Y.C., Lehman, V.N., Averette, A.F., Perfect, J.R., Heitman, J. 2013. Posaconazole Exhibits In Vito and In Vivo Synergistic Antifungal Activity with Caspofungin or FK506 against Candida albicans. PLoS One. 8(3):e57672.
Chen, Y.C., Lehman, V.N., Lewit, Y. Averette, A. F., Heitman, J. 2013. Calcineurin Governs Thermotolerance and Virulence of Cryptococcus gattii. G3. 3:527-539.
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