Faculty and Research
Heitman Lab Members
Yong-Sun Bahn, PhD
Visiting Associate Professor
340 CARL Building
Box 3546 DUMC
Durham, N.C. 27710
Yong-Sun Bahn is an associate professor in the Department of Biotechnology at Yonsei University in South Korea. He received his Ph.D.(Ohio State University, USA) working with
Paula Sundstrom on the cAMP signaling pathway of a human fungal pathogen Candida albicans. In postdoctoral studies with Joseph Heitman (Duke University, USA), he investigated
the molecular mechanisms of various stress sensing signal cascades that affect the virulence of another human fungal pathogen, Cryptococcus neoformans. He became an independent researcher as a faculty member at Soongsil University (South Korea) in 2006 and moved to his current position in Yonsei University in 2008. Stemming from his research background,
his current focus is on genome-wide, comprehensive understanding of complex signaling cascades that govern growth, differentiation, stress response, and virulence of human fungal pathogens by using C. neoformans as a model system.
Janbon G*, Ormerod KL, Paulet D, Byrnes III EJ, Chatterjee G, Yadav V, Hon CC, Billmyre RB, Brunel F, Bahn YS, Chen W, Chen Y, Chow EWL, Coppee JY, Floyd-Averette A, Gaillardin C, Gerik KJ, Goebels C, Goldberg J, Gonzalez-Hilarion S, Gujja S, Hamlin JL, Hsueh YP, Ianiri G, Jones S, Kodira CD, Lam W, Marra M, Mesner LD, Mieczkowski PA, Moyrand F, Nielsen K, Proux C, Rossignol T, Schein JE, Sun S, Wood IA, Zeng Q, Neuveglise C, Newlon CS, Perfect JR, Lodge JK, Idnurm A, Stajich JE, Kronstad JW, Sanyal K, Heitman J*, Fraser JA, Cuomo CA,* and Dietrich FS*. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genetics 2014, In press.
Bang S, Lee D, Kim H, Park J, and Bahn YS*. Global transcriptome analysis of eukaryotic genes affected by gromwell extract. Journal of the Science of Food and Agriculture 2014. Feb 94:445-452. (*corresponding author)
Cheon SA, Jung KW, Bahn YS*, and Kang HY*. The unfolded protein response (UPR) pathway in Cryptococcus. Virulence 2014 Feb 5(2):1-10. (*corresponding author)
Bahn YS* and Jung KW. Stress signaling pathways for the pathogenicity of Cryptococcus. Eukaryotic Cell 2013 Dec 12(12):1564-1577. (*corresponding author)
Upadhyal R, Kim H, Jung KW, Park G, Lam W, Lodge JK*, and Bahn YS*. Sulfiredoxin plays peroxiredoxin-dependent and –independent roles via the HOG signaling pathway in Cryptococcus neoformans and contributes to fungal virulence. Molecular Microbiology 2013 Oct 90(3):630-648. (*corresponding author)
Singh H, Kim H, Song H, Joe M, Kim D, Bahn YS, Choi JI, and Lim S. A novel radiation-resistant strains of Filobasidium sp. Isolated from the West Sea of Korea. Journal of Microbiology and Biotechnology 2013 23(11):1493-1499.
Yang DH, Maeng S, and Bahn YS*. Msi1-like (MSIL) proteins in fungi. Mycobiology 2013 Mar 41(1):1-12. (*corresponding author)
Jung KW, Kang HA, and Bahn YS*. Essential roles of the Kar2/BiP molecular chaperone downstream of the UPR pathway in Cryptococcus neoformans. PLoS ONE 2013 8(3):e58956. (*corresponding author)
Yang DH, Maeng S, Strain AK, Floyd A, Nielsen K, Heitman J, and Bahn YS*. Pleiotropic roles of the Msi1-like protein, Msl1, in Cryptococcus neoformans. Eukaryotic Cell 2012 Dec;11(12):1482-1495. (*corresponding author)
Park JN, Lee DJ, Kwon O, Oh DB, Bahn YS, and Kang HA. Unraveling the unique structure and biosynthesis pathway of N-linked glycans in the human fungal pathogen Cryptococcus neoformans by glycomics analysis. Journal of Biological Chemistry 2012 Jun;287(23):19501-19515.
Jung KW, Strain AK, Nielsen K, Jung KH, and Bahn YS*. Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway. Fungal Genetics and Biology 2012 Apr;49:332-345. (*corresponding author)
Song MH, Lee JW, Kim MS, Yoon JK, White TC, Floyd A, Heitman J, Strain AK, Nielsen JN, Nielsen K, and Bahn YS*. A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. Eukaryotic Cell 2012 Jan;11(1):53-67. (*corresponding author)
Okagaki LH, Wang Y, Ballou ER, O’Meara TR, Bahn YS, Alspaugh JA, Xue C, and Nielsen K*. Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli.
Eukaryotic Cell 2011 Oct;10(10):1306-1316. (*corresponding author)
Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS*, and Kang HY*. Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathogens 2011 Aug;7(8):e1002177. (*co-corresponding authors)
Lee JW, Ko YJ, Kim SY, and Bahn YS*. Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans. Eukaryotic Cell 2011 Jul;10(7):988-1002. (*corresponding author)
Kim SY, Ko YJ, Jung KW, Strain A, Nielsen K, and Bahn YS*. Hrk1 plays both Hog1-dependent and –independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans. PLoS ONE 2011 Apr;6(4):e18769. (*corresponding author)
Jung KW, Kim SY, Okagaki LH, Nielsen K, and Bahn YS*. Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone response MAPK signaling pathway. Fungal Genetics and Biology 2011 Feb;48(2):154-165. (*corresponding author)
Janbon G, Maeng S, Yang DH, Ko YJ, Jung KW, Moyrand F, Floyd A, Heitman J, and Bahn YS*. Characterizing the role of RNA silencing components in Cryptococcus neoformans. Fungal Genetics and Biology 2010 Dec;47(12):1070-1080. (*corresponding author)
Kim MS, Ko YJ, Maeng S, Floyd A, Heitman J, and Bahn YS*. Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans. Genetics 2010 Aug;185:1207-1219. (*corresponding author)
Jung KW, Maeng S, and Bahn YS*. Functional Characterization of cAMP-Regulated Gene, CAR1, in Cryptococcus neoformans. Mycobiology 2010 Mar;38(1):26-32. (*corresponding author)
Ko YJ, Kwon YW, Na H, and Bahn YS*. Pathogenomic Signaling Networks and Antifungal Drug Development for Human Fungal Pathogen Cryptococcus neoformans. Korean Journal of Microbiology and Biotechnology 2010 March 38(1):13-18 (*corresponding author)
Maeng S, Ko YJ, Kim GB, Jung KW, Floyd A, Heitman J, and Bahn YS* Comparative transcriptome analysis reveals novel roles of the Ras- and cAMP-signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. Eukaryotic Cell 2010 Mar;9(3):360-78. (*corresponding author)
Han KH, Chun YH, Pimentel Figueiredo BDC, Soriani FM, Savoldi M, Almeida A, Rodrigues F, Cairns, Bignell CTE, Goldman MHS, Kim JH, Bahn YS, Goldman GH, and da Silva Ferreira ME. The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans. Molecular Microbiology, 2010 75(6):1372-1388.
Kim MS, Kim SY, Yoon JK, Lee YW, and Bahn YS*. An efficient gene-disruption method in Cryptococcus neoformans by double-joint PCR with NAT-split markers. Biochemical and Biophysical Research Communications, 2009 390(3):983-988.(*corresponding author)
Jung KW and Bahn YS*. The Stress-Activated Signaling (SAS) Pathways of a Human Fungal Pathogen, Cryptococcus neoformans. Mycobiology, 2009 37(3):161-170. (*corresponding author)
Ko YJ, Yu YM, Kim GB, Lee GW, Maeng PJ, Kim SS, Floyd A, Heitman J, and Bahn YS*. Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryotic Cell, 2009 Aug;8(8):1197-1217. (*corresponding author)
Bahn YS*, Master and commander in fungal pathogens: the two-component system and the HOG signaling pathway. Eukaryotic Cell, 2008 Dec;7(12):2017-36. (*corresponding author)
Bahn YS, Geunes-Boyer S, and Heitman J. Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans. Eukaryotic Cell,2007 Dec;6(12):2278-89.
Bahn YS, Molenda M, Staab JF, Lyman CA, Gordon LJ, and Sundstrom P. Genome-wide transcriptional profiling of the cyclic AMP-dependent signaling pathway during morphogenic transitions of Candida albicans, Eukaryot. Cell, 2007, Dec;6(12):2376-90.
Ponniah G, Rollenhagen C, Bahn YS, Staab JF, and Sundstrom P. State of differentiation defines buccal epithelial cell susceptibility to cross2 linking by Candida albicans Hwp1, J. Oral Pathol. Med. 2007 Sep, 36(8):456-67.
Bahn YS, Xue C, Idnurm A, Rutherford J, Heitman J, and Cadenas M. Sensing the environment: Lessons from fungi. Nature Reviews Microbiology., 2007 Jan, 5(1):57-69.
Bahn YS*, and Muhlschlegel F. CO2 sensing in fungi and beyond. Current Opinion in Microbiology, 2006 Dec, 9(6):572-578. (*corresponding author)
Bahn YS, Kojima K, Cox G, and Heitman J. A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Molecular Biology of the Cell. 2006, Jul; 17(7):3122-35.
Kojima K, Bahn YS, and Heitman J. Calcineurin, Mpk1, and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology, 2006 Mar; 152(Pt 3): 591-604.
Xue C, Bahn, YS, Cox GM, and Heitman J. G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Molecular Biology of the Cell, 2006 Feb; 17(2): 667-679. Epub 2005 Nov 16.
Hicks JK, Bahn YS, and Heitman J. Pde1 phosphodiesterase modulates cAMP levels through a protein kinase A mediated negative feedback loop in Cryptococcus neoformans. Eukaryotic Cell, 2005 Dec;4(12): 1971-1981.
Bahn YS, Cox GM, Perfect JR, and Heitman J. Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence. Current Biology, 2005 Nov 22; 15(22): 2013-2020
Idnurm A, Bahn YS, Nielsen K, Lin X, Fraser JA, and Heitman J. Deciphering the model pathogenic fungus Cryptococcus neoformans. Nature Reviews Microbiology, 2005 Oct; 3(10): 753-64. Review
Bahn YS, Kojima K, Cox GM and Heitman J. Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Molecular Biology of the Cell, 2005 May; 16(5): 2285-300. Epub 2005 Feb 23.
Bahn YS, Hicks JK, Giles SS, Cox GM, and Heitman J. Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryotic Cell, 2004 Dec; 3(6): 1476-91.
Staab JF, Bahn YS, Tai CH, Cook PF, and Sundstrom P. Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification. Journal of Biological Chemistry, 2004 Sep 24; 279(39): 40737-47., Epub 2004 Jul 15.
Bahn YS, Staab JF, and Sundstrom P. Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicans, Molecular Microbiology, 2003 Oct; 50(2): 391-409.
Staab JF, Bahn YS, and Sundstrom P. Integrative, multifunctional plasmids for hypha-specific or constitutive expression of green fluorescent protein in Candida albicans. Microbiology, 2003 Oct; 149(Pt 10): 2977-86.
Bahn YS and Sundstrom P. CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth and cyclic AMP levels, and is required for virulence of Candida albicans. Journal of Bacteriology, 2001 May; 183 (10): 3211-3223.
Bahn YS, Park JM, Bai DH, Takase S, and Yu JH. YUA001, a novel aldose reductase inhibitor isolated from alkalophilic Corynebacterium sp. YUA25. I. Taxonomy, fermentation, isolation and characterization. Journal of Antibiotics (Tokyo), 1998 Oct; 51(10): 902-907.
1. “Applied Microbiology”, published date 2007-02-28, publisher: Hyo-il,
- Authors : Yu-Ju Hyun, et al (co-authored by Yong-Sun Bahn).
2. “Food Microbiology”, published date 2007-08-30, publisher: Hyo-il,
- Authors : Yu-Ju Hyun, et al (co-authored by Yong-Sun Bahn).
3. “Applied Microbial Experiments”, published date 2007-09-28 publisher: Hyo-il,
- Authors : Yu-Ju Hyun, et al (co-authored by Yong-Sun Bahn).
4. “Cryptococcus : from human pathogen to model yeast”, 2011, publisher: ASM press
- Editor Joseph Heitman et al. (co-authored by Yong-Sun Bahn)
5. “Methods in Molecular Biology: Host-Fungus interactions”, 2012, publisher: Springer press
- Editors: Alexandra C. Brand and Donna M. MacCallum
- ISBN: 978-1-61779-538-1
- Chapter 5: Targeted Gene Disruption in Cryptococcus neoformans Using Double-Joint PCR with Split Dominant Selectable Markers (authors: Kim MS, Kim SY, Jung KW, and Bahn YS)
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