Gary Cox, MD
Associate Professor
Department of Medicine, Division of Infectious Diseases
biography  •  lab members  •  website

Selected Publications:

• Wormley FL Jr., Heimrich G, Miller JL, Perfect JR, and Cox GM. Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. Infect Immun., 73:5022-30, 2005.
  
  
• Nielsen K, Cox GM, Litvintseva AP, Mylonakis E. Malliaris SD, Benjamin DK Fr., Gilles SS, Mitchell TG, Casadevall A, Perfect JR, and Heitman J. Cryptococcus neoformans [alpha] strains preferentially disseminate to the central nervous system during coinfection. Infect Immun., 73:4922-33, 2005.
  
  
• Nielsen K, Marra RE, Hagen F, Boekhout T, Mitchell TG, Cox GM, and Heitman, J. Interaction between genetic background and the mating type locus in Cryptococcus neoformans virulence potential. Genetics, June 18 [Epub ahead of print], 2005.
  
  
• Wormley FL Jr., Cox GM, and Perfect JR. Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain. Microb Pathog., 38:113-23, 2005.
  
  
• Bahn YS, Kojima K, Cox GM, and Heitman, J. Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol Biol Cell, 16:2285-300, 2005.
  
  
• Pukkila-Worley R, Gerrald QD, Kraus PR, Boily MJ, Davis MJ, Giles SS, Cox GM, Heitman J, Alspaugh JA. Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. Eukaryot Cell., 4:190-201, 2005.
  
  
• Giles SS, Batinic-Haberle I, Perfect JR, and Cox GM. Cryptococcus neoformans mitochnodrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. Eukaryot Cell., 4:46-54, 2005.
  
  
• Giles SS, Perfect JR, and Cox GM. Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. Fungal Genet Biol., 42:20-9, 2005.
  
  
• Bahn YS, Hicks JK, Giles SS, Cox GM, and Heitman J. Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryot Cell., 3:1476-91, 2004.
  
  
• Wang P, Cox GM, and Heitman J. A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. Curr Genet., 46:247-55, 2004.
  
  
• Kraus PR, Boily MJ, Giles SS, Stajich JE, Allen A, Cox GM, Dietrich FS, Perfect JR, and Heitman J. Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray. Eukaryot Cell., 3:1249-60, 2004.
  
  
• Pascon RC, Ganous TM, Kingsbury JM, Cox GM, and McCusker JH. Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. Microbiology, 150:3013-23, 2004.
  
  
• Kingsbury JM, Yang Z, Ganous TM, Cox GM, and McCusker JH. Novel chimeric spermidine synhase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. Eukaryot Cell., 3:752-63, 2004.
  
  
• Hull CM, Cox GM, and Heitman J. The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans. Infect Immun., 72:3643-5, 2004.
  
  
• D'Souza CA, Hagen F, Boekhout T, Cox GM, and Heitman J. Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals. Curr Genet., 46:92-102, 2004.
  
  
• Kingsbury JM, Yang Z, Ganous TM, Cox GM, and McCusker JH. Cryptoccocus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. Microbiology, 150:1547-58, 2004.
  
  
• Olszewski MA, Noverr MC, Chen GH, Toews GB, Cox GM, Perfect JR, and Huffnagle GB. Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. Am J Pathol., 164:1761-71, 2004.
  
  
• Hicks JK, D'Souza CA, Cox GM, and Heitman, J. Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. Eukaryot Cell., 3:14-26, 2004.
  
  
• DeJesus-Berrios M, Liu L, Nussbaum JC, Cox GM, Stamler JS, and Heitman, J. Enzymes that counteract nitrosative stress promote fungal virulence. Curr Biol., 13:1963-8, 2003.
  
  
• Fox DS, Cox GM, and Heitman J. Phospholipid-binding protein Cts1 controls septation and functions coordinate with calcineurin in Cryptococcus neoformans. Eukaryot Cell., 2:1025-35, 2003.
  
  
• Noverr MC, Cox GM, Perfect JR, Huffnagle GB. Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production. Infect Immun., 71:1538-47, 2003.
  
  
• Cox GM, Harrison TS, McDade HC, Taborda CP, Heinrich G, Casadevall A, and JR Perfect. Superoxide dismutase is a virulence factor for Cryptococcus neoformans. Infect. Immun.; 71:173-80, 2003.
  
  
• Gorlach J.M., McDade H.C., Perfect J.R. and Cox, GM. Adapting antisense repression to Cryptococcus neoformans. Microbiology, 148:213-219, 2002.
  
  
• Hopfer RL, Starks SD and Cox GM. The use of flow cytometry as a tool for monitoring filament formation of fungi. Medical Mycology; 39:103-7, 2001.
  
  
• McDade H and Cox GM. Development of a new dominant selectable marker in Cryptococcus neoformans. Medical Mycology; 39:151-154, 2001.
  
  
• Cox GM, McDade HC, Gottfredsson M, Chen SCA, Wright LC, Sorrell TC, Ghannoum M, and Perfect JR. Extracellular phospholipase is a virulence factor in experimental cryptococcosis. Molecular Microbiology; 39:166-175, 2001.
  
  
• Perfect JR and Cox GM. Virulence mechanisms for fungi. Clin Micro Newsletter; 22:113-119, 2000.
  
  
• Cox GM, Mukherjee J, Cole GT, Casadevall A, and Perfect JR. Urease as a virulence factor in experimental cryptococcosis. Infection and Immunity, 68:443-8, 2000.
  
  
• Cox GM and Perfect JR. The management of candidemia. Clinical Updates in Fungal Infections, 2000.