J. Andrew Alspaugh, MD
Associate Professor
Department of Medicine, Division of Infectious Diseases
biography  •  lab members  •  website

Selected Publications:

• C Skrynia, DM Binninger, JA Alspaugh and PJ Pukkila. Molecular characterization of TRP1, a gene encoding for tryptophan synthetase in the basidiomycete C. cinereus. Gene 81:73-82, 1989.
  
  
• JA Alspaugh and DL Granger. Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis. Infect Immun 59:2291-2296, 1991.
  
  
• JA Alspaugh, JR Perfect, and J Heitman. Cryptococcus neoformans mating and virulence are regulated by the G-protein a subunit GPA1 and cAMP. Genes & Dev 11:3206-3217, 1997.
  
  
• JA Alspaugh and JR Perfect. Infections due to zygomycetes and other rare opportunistic fungi. Seminars in Respiratory and Critical Care Medicine 18:265-279, 1997.
  
  
• GM Lyons, JA Alspaugh, FT Meredith, LJ Harrell, V Tapson, RD Davis, and SS Kanj. Mycoplasma hominis pneumonia complicating bilateral lung transplantation: Case report and review of the literature. Chest 112: 1428-1432, 1997.
  
  
• MA Mallory, RE Nettles, JA Alspaugh, and DJ Sexton. Community acquired prosthetic valve endocarditis due to methicillin-resistnt Staphylococcus aureus. Clin Infect Dis 24:1272-1273, 1997.
  
  
• JA Alspaugh, JR Perfect, and J Heitman. Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. Fungal Genet Biol 25:1-14, 1998.
  
  
• VG Fowler Jr, FM Nacinovich, JA Alspaugh, and GR Corey. Prosthetic joint infection with Histoplasms capsulatum: case report and review of the literature. Clin Infect Dis 26:1017, 1998.
  
  
• S Sudarshan, RC Davidson, J Heitman, and JA Alspaugh. Molecular characterization of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. Fungal Genet Biol, 1999, 27: 36-48. 1999.
  
  
• C Yue, LM Cavallo, JA Alspaugh, P Wang, GM Cox, JR Perfect, and J Heitman. The STE12α homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans, Genetics 153: 1601-1615, 1999.
  
  
• J Heitman, B Allen, JA Alspaugh, KJ Kwon-Chung. On the origins of congenic MATα and MATa strains of the pathogenic yeast Cryptococcus neoformans. Fungal Genet Biol 28: 1-5, 1999.
  
  
• JA Alspaugh, RC Davidson, and J Heitman. Morphogenesis in Cryptococcus neoformans. In J. F. Ernst and A. Schmidt, eds. Dimorphism in Human Pathogenic and Apathogenic Yeasts. Karger: Basel, 1999.
  
  
• RC Davidson, MC Cruz, RA Sia, BM Allen, JA Alspaugh, and J Heitman. Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. Fungal Genet Biol, 29: 38-48, 2000.
  
  
• JA Alspaugh, LM Cavallo, JR Perfect and J Heitman. RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Molecular Microbiology, 36: 352-365, 2000.
  
  
• CA D’Souza, JA Alspaugh, C Yue, T Harashima, GM Cox, JR Perfect, and J Heitman. Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Molecular and Cellular Biology 21:3179-3191, 2001.
  
  
• JA Alspaugh, R Pukkila-Worley, T Harashima, LM Cavallo, D Funnell, GM Cox, JR Perfect, JW Kronstad, and J Heitman. Adenylyl cyclase functions downstream of the Gα protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryotic Cell 1:75-84, 2002.
  
  
• MS Waugh, CS Breeding, CM DeCesare, GM Cox, J Heitman, and JA Alspaugh. Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. Microbiology 148: 191-201, 2002.
  
  
• D Schiappa, A Geuyikian, S Kakar, JA Alspaugh, JR Perfect, and PR Williamson. An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow. Medical Mycology 40: 1-5, 2002.
  
  
• JA Alspaugh and JR Perfect. Cryptococcal meningitis. Current Treatment Options in Infectious Diseases 4: 75-80, 2002.
  
  
• Z Yang, JA Alspaugh, GM Cox, JM McCusker. Requirement of the C. neoformans MET3 gene for growth and pathogenicity. Microbiology 148: 2617-2625, 2002.
  
  
• MS Waugh, MA Vallim, J Heitman, JA Alspaugh. Ras1 controls pheromone expression and response during mating in C. neoformans. Fungal Genetics and Biology, 38:110-121, 2003.
  
  
• R Pukkila-Worley and JA Alspaugh. Cyclic AMP signaling in Cryptococcus neoformans. FEMS Yeast Research 4:361-367, 2003.
  
  
• MA Vallim, L Fernandes, and JA Alspaugh. The RAM1 gene encoding a protein-farnesyltransferase {beta}-subunit homologue is essential in Cryptococcus neoformans. Microbiology 150:1925-1935, 2004.
  
  
• R Pukkila-Worley, QD Gerrald, PR Kraus, MJ Boily, MJ Davis, SS Giles, GM Cox, J Heitman, and JA Alspaugh. Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. Eukaryotic Cell 4:190-201, 2005.
  
  
• JA Fraser, JC Huang, R Pukkila-Worley, JA Alspaugh, TG Mitchell, and J Heitman. Chromosomal translocation and segmental duplication in Cryptococcus neoformans. Eukaryotic Cell 4:401-406, 2005.
  
  
• MA Vallim, CB Nichols, L. Fernandes, KL Cramer, and JA Alspaugh. A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. Eukaryotic Cell 4:1066-1078, 2005.
  
  
• BD Alexander, ES Dodds Ashley, RM Addison, JA Alspaugh, NJ Chao, and JR Perfect. Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 8:13-20, 2006.
  
  
• KL Cramer, QD Gerrald, CB Nichols, MS Price, and JA Alspaugh. Transcription factor Nrgl mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. Eukaryotic Cell 5:1147-1156, 2006.
  
  
• SS Giles, JE Stajich, CB Nichols, QD Gerrald, JA Alspaugh, FS Dietrich, and JR Perfect. The Cryptococcus neoformans catalase gene family and its role in antioxidant defense. Eukaryotic Cell 5:1447-1459, 2006.
  
  
• GM Olson, DS Fox, P Wang, JA Alspaugh, and KL Buchanan. Role of protein O-Mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans. Eukaryotic Cell 6:222-234, 2007. [Epub 2006 Dec 1].
  
  
• CB Nichols, ZH Perfect, and JA Alspaugh. A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. Molecular Microbiology 63:1118-1130, 2007.