DUKE BACTERIOLOGY RESEARCH UNIT
Faculty and Research

Patrick Seed, MD, PhD
Assistant Professor
Department of Pediatrics
Department of Molecular Genetics and Microbiology
biography  •  lab members  •  website

Selected Publications:

• Wright KJ, Seed PC, Hultgren SJ. Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Cell Microbiol, 2007; 9:2230-2241.
  
  
• Uhlmann EJ, Seed PC, Schwan TG, Storch GA. Tick-borne relapsing fever polymerase chain reaction of tick-borne relapsing fever caused by Borrelia hermsii. Pediatr Infect Dis J, 2007;26:267-269.
  
  
• Justice SS, Hunstad DA, Seed PC, Hultgren SJ. Filamentation by Escherichia coli subverts innate defenses during urinary tract infection. Proc Natl Acad Sci USA, 2006; 103:19884-19889.
  
  
• Pinkner, JS, Remaut H, Buelens F, Miller E, Aberg V, Pemberton N, Hedenström M, Larsson A, Seed PC, Waksman G, Hultgren S, Almqvist F. A novel class of antibiotics targeting virulence factors: chemical knockout of pilus biogenesis in uropathogenic bacteria. Accepted, PNAS.
  
  
• Justice SS, Hunstad DA, Seed PC, Hultgren SJ. Filamentation by E. coli subverts innate defenses during urinary tract infection. In revision, PNAS; 103(52):19884-19889. [Epub 2006 Dec 15].
  
  
• Uhlmann E, Seed PC, Schwan TG, Storch GA. Diagnosis by polymerase chain reaction of tick-borne relapsing fever caused by Borrelia hermsii. Ped Infect Dis J, 2006. In Press.
  
  
• Elward A, Grim A, Schroeder P, Kieffer P, Sellenriek P, Ferrett R, Adams HC, Phillips V, Barton R, Mays D, Lawrence S, Seed P, Holzmann-Pazgal G, Polish L, Leet T, Frazer V.  Salmonella javiana outbreak in Children's Hospital. Infect Control Hosp Epidemiol, 2006; 27:586-592.
  
  
• Wright KJ*, Seed PC *, Hultgren SJ. UPEC flagella aid in efficient urinary tract colonization. Infect Immun, 2005; 73:7657-7668. (*Co-first authors)
  
  
• Seed PC, Hultgren SJ. Blueprinting the regulatory response of Escherichia coli to the urinary tract. Trend Micro, 2005; 13(5):246-8.
  
  
• DeKievit T*, Seed PC* , Nezezon J, Passador L, Iglewski BH.   RsaL, a novel repressor of virulence gene expression in Pseudomonas aeruginosa . J Bacteriol, 1999; 181 (7):2175-2184. (*Co-first authors)
  
  
• Pesci EC, Pearson JP, Seed PC, Iglewski BH. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol, 1997; 179(10):3127-3132.
  
  
• Preston MJ, Seed PC, Toder DS, Iglewski BH, Ohman DE, Gustin JK, Goldberg JB, Pier GB. Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. Infect Immun., 1997; 65(8):3086-3090.
  
  
• Seed PC, Passador L, Iglewski BH. Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy. J Bacteriol, 1995; 177(3):654-659.