Jörn Coers, PhD
Assistant Professor
Department of Molecular Genetics and Microbiology
biography  •  lab members  •  website

Representative Publications

• Coers J. *, Monahan C. *, Roy C.R. (*Authors contributed equally to this paper) Modulation of phagosome biogenensis by Legionella pneumophila creates an organelle permissive for intracellular growth. Nature Cell Biology. 1999 Nov;1 (7):451-453.
  
  
• Roy C.R., Coers J. Exploitation of macrophages as a replication niche by Legionella pneumophila: response. Trends Microbiol. 2000 Feb;8(2):49-50.
  
  
• Coers J., Kagan J.C., Matthews M., Nagai H., Zuckman D.M., Roy C.R. Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Mol Microbiol. 2000 Nov;38(4):719-736.
  
  
• Kralovics R., Buser A.S., Teo S.S., Coers J., Tichelli A., Van Der Maas A.P., Skoda R.C. Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. Blood. 2003 Sep 1;102(5):1869-1871.
  
  
• Coers J., Ranft C., Skoda R.C. A truncated isoform of c-mpl with an essential C-terminal peptide targets the full-length receptor for degradation. J. Biol Chem. 2004 Aug 27;279(35):36397-36404.
  
  
• Bernstein-Hanley I., Balsara Z.R., Ulmer W., Coers J., Starnbach M.N., Dietrich W.F. Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. Genes Immun. 2006 Mar;7(2):122-129.
  
  
• Bernstein-Hanley I.*, Coers J.*, Balsara Z.R., Taylor G.A., Starnbach M.N., Dietrich W.F. (*Authors contributed equally to this paper) The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. Proc Natl Acad Sci U S A. 2006 Sept 19;103(38):14092-14097.
  
  
• Coers J.*, Vance R.E.*, Fontana M.F., Dietrich W.F. (*Authors contributed equally to this paper) Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell Microbiol. 2007 Oct;9(10):2344-2357.
  
  
• Coers J., Bernstein-Hanley I., Grotsky D., Parvanova I., Howard, J.C., Taylor, G.A., Dietrich W.F., Starnbach, M.N. Chlamydia muridarum evades growth restriction by the IFNg inducible host resistance factor Irgb10. J. Immunol. 2008 May 1;180(9):6237-6245.
  
  
• Tiedt R.*, Coers J.*, Ziegler S., Wiestner A., Hao-Shen H., Bornmann C., Schenkel J. Karakhanova S., de Sauvage F.J., Jackson C.W., Skoda R.C. (*Authors contributed equally to this paper). Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood. 2009 Feb 19;113(8):1768-1777.
  
  
• Henry S.C., Daniell X.G., Burrough, A.R., Indaram M., Howell D.N., Coers J., Starnbach M.N., Hunn J.P., Howard J.C., Feng C.G., Sher A., Taylor G.A. Balance of Irgm protein activities determines IFN-induced host defense. J. Leukoc. Biol. 2009 May;85(5):877-885.
  
  
• Coers J., Starnbach M.N., Howard J.C. Modelling infectious disease in mice: Co-adaptation and the role of host-specific IFNy responses. PLOS Pathogens 2009 May;5(5):e1000333.
  
  
• Khaminets A., Könen-Waisman S., Hunn J.P., Zhao Y.O., Preukschat D., Coers, J., Boyle J.P., Ong Y., Reese M.L., Boothroyd J.C., Reichmann G., Howard J.C. Coordinated, hierarchical loading of multiple IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole correlates inversely with parasite virulence. Cell Microbiol. 2010 In press.
  
  
• Traver M.K., Henry S.C., Cantillana V., Oliver T., Hunn J.P., Howard J.C., Beer S., Pfeffer K., Coers J., Taylor G.A. Immunity-related gtpase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. J Biol Chem., 2011 Jul 12. [Epub ahead of print].
  
  
• Coers J., Gondek D.C., Olive A.J., Rohlfing A., Taylor G.A., Starnbach M.N. Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog., 2011 Jun;7(6):e1001346. [Epub 2011 Jun 23].