Graduate Student Directory


Matthew Tay

Graduate Student

114 SORF
Box 103020 DUMC
Durham, N.C. 27710


Phone: 919.684.2771
Fax: 919.684.5230
Email: matthew.zirui.tay@duke.edu  

Matthew Tay

Research interests: infectious disease, immunology, informatics

I was born and raised in Singapore, a metropolitan tropical island just 85 miles north of the equator. For undergraduate studies, I went to Brown University in Providence, RI. There, I received a degree in Immunology, did an undergraduate thesis project tracking the evolution of HIV drug-resistance mutations, and experienced my first snowfall. 

My research interest lies in host-pathogen interactions. I am concerned about the state of infectious diseases in the world today: drug-resistant strains of bacteria and parasites are rapidly becoming prevalent, and no effective vaccines are available for many important viruses such as HIV, influenza, and dengue virus.  I believe that the answer to this problem is a robust understanding of both pathogen and the immune system. All pathogens have evolved methods to avoid the immune system in order to survive in their host, and understanding such virulence factors allow us to develop effective therapeutics that interfere with them to alter the balance in favor of the host. I am interested in applying both traditional as well as newer computational techniques to approach these issues.

At Duke, my first rotation was in the Kuehn lab, where I studied the impact of P. aeruginosa aminopeptidase (PaAP), an uncharacterized protein abundantly found in P. aeruginosa outer membrane vesicles, on the virulence of the bacteria in vitro. My second rotation is in the Tomaras lab, where I am studying the ability of mixtures of monoclonal antibodies to capture infectious and non-infectious HIV virions. 

On the side, I enjoy reading (I am a big fan of Tolkien), and after hours you might find me lounging at home on the sofa with a book in one hand and my pet hedgehog on my lap. 

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