Graduate Student Directory
MGM Graduate Student
0045 CARL Building
Box 3053 DUMC
Durham, N.C. 27710
Research Interest: The role of a dysregulated innate immune
system in inflammatory conditions such as rheumatoid arthritis.
Brandt Levitt began his academic career at the University of Wisconsin – Madison in the Bacteriology department. While studying microbial physiology, host pathogen interactions and innate immunity, he worked in the laboratory of Patricia Keely of the pharmacology department, where he dissected the role of the R-Ras oncogene in aberrant cellular signaling that results in breast cancer. After completing his bachelor's degree, Brandt spent three years in the biotechnology industry, developing molecular diagnostics tests for infectious diseases ranging from RNA viruses to drug resistant bacteria for Third Wave Technologies. Brandt then went on to study the innate immune system and autoimmunity in the laboratory of Michael Holers at the University of Colorado, publishing half a dozen articles about complement and Rheumatoid Arthritis. In 2009, Brandt joined the Duke Molecular Genetics and Microbiology PhD program because of its strength in host-pathogen interactions. In 2010, he joined the Garcia-Blanco laboratory where he studies exonucleases that act as pro-flaviviral host factors for Dengue and Yellow Fever Virus RNA replication. He anticipates a career in public health, utilizing the problem solving and critical thinking skills gained through research.
Initiation of the Alternative Pathway of Murine Complement by Immune Complexes is Dependent on N-Glycans in IgG Antibodies. Banda NK, Takahashi M, Wood A, Levitt B, Rudd P, Royle L, Abrahams J, Stahl G, Holers VM, Arend WP. Arthritis and Rheumatism. 58(10):3081-3089. October 2008.
Targeted Inhibition of the Complement Alternative Pathway with Complement Receptor 2 and Factor H Attenuates Collagen Antibody-Induced Arthritis in Mice. Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, and Holers VM. J. Immunol. 183:5928-5937. November 2009.
Complement Activation Pathways in Murine Immune Complex-induced Arthritis and in C3a and C5a Generation in vitro. Banda, NK, Levitt, B, Wood, AK, Takahashi K, Stahl GL, Holers VM and Arend WP. Clinical & Experimental Immunology, 159:100–108. October 2009.
Treatment with Cl-amidine, a peptidyl arginine deiminase (PAD) inhibitor, significantly reduces collagen-induced arthritis (CIA). Willis VC, Gizinski A, Banda NK, Knuckley B, Cordova K, Causey CP, Levitt B, Glogowska MJ, Benbarak M, Chandra P, Kulik L, Arend WP, Robinson WH, Thompson PR, and Holers VM. J. Immunol., 182:50-6. Apr 2009.
Essential Role of Complement Mannose-Binding Lectin-Associated Serine Proteases-1/3 in the Murine Collagen Antibody-Induced Model of Inflammatory Arthritis. Banda NK, Levitt B, Takahashi M, Glogowska M, Nicholas J, Takahashi K, Stahl GL, Fujita T, Arend WP, Holers VM. J Immunol. Sep 24 2010.
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