Faculty and Research

Robin P. Wharton, PhD
Professor
bio  •  lab members  •  lab website

Representative Publications:

• Gupta, Y.K., Nair, D.T., Wharton, R.P., and Aggarwal, A.K. (2007) Structures of human Pumilio with non-cognate RNAs reveal flipped-out nucleotides (submitted).

• Kadyrova, L., Habara, Y., Lee, T.H. and Wharton, R.P. (2007). Translational control of maternal CyclinB mRNA by Nanos in the Drosophila germ line. Development 134: 1519-1527. [PubMed]

• Song, Y., Lee, T., Fee, L., and Wharton, R.P. (2007). The molecular chaperone Hsp90 is required for mRNA localization in Drosophila melanogaster embryos. Genetics 176: 2213-2222. [PubMed]

• Lee, C.-Y., Wilkinson, B.D., Siegrist, S.E., Wharton, R. P., and Doe, C. Q. (2006) Brain tumor (Brat) is an asymmetrically localized Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev. Cell 10: 441-49. [PubMed]

• Edwards, T.A., Butterwick, J.A., Zeng, L., Gupta, Y.K., Wang, X., Wharton, R. P., Palmer, A.G., Aggarwal, A.K. (2005). Solution structure of the Vts1 SAM domain in the presence of RNA. J. Mol. Biol. Dec 20, 2005 (epub). [PubMed]

• Menon, K.P., Sanyal, S., Habara, Y., Sanchez, R., Wharton, R.P., Ramaswami, M., and Zinn, K. (2004). The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Neuron 44: 663-676. [PubMed]

• Araki, M., Wharton, R.P., Tan, Z., Yu, H, and Asano, M. (2003). Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. EMBO J. 22: 6115-6126. [PubMed]

• Edwards, T.A., Wilkinson, B.D., Wharton, R.P. and Aggarwal, A.K. (2003). Model of the Brain tumor-pumilio translation repressor complex. Genes and Development 17:2508-2513. [PubMed]

• Green, J.B., Gardner, C.D., Wharton, R.P., and Aggarwal, A.K. (2003). RNA recognition via the SAM domain of Smaug. Mol. Cell 11: 1537-1548. [PubMed]