Debra L. Silver, PhD
Assistant Professor
Duke Institute for Brain Sciences Investigator
research • biography • lab members • publications • lab website

Representative Publications:

• Silver, DL*, Leeds, K, Hwang, H, Miller, EE, and Pavan, WJ*. The RNA binding protein, Magoh, is critical for neural crest derived melanocyte development. The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. Developmental Biology. 2013
  (*co-corresponding Author)

• Silver, DL, Watkins-Chow, D Schreck, K, Pierfelice, T, Larson, DM, Burnetti, A, Liaw, H, Myung, K, Walsh, CA, Gaiano, N, and Pavan, WJ. The exon junction complex component, Magoh, controls brain size by regulating neural stem cell division. Nature Neuroscience. May; 13(5):551-558. 2010
  (Accompanying News and Views by Dave, KA. Regulating Brain Size Nature Neuroscience, May; 13(5):531. 2010)
  
  
• McCulloch, DR, Dixon, LJ, Nelson, C, Silver, DL, Wylie, J, Sasaki, T, Cooley, M, Argraves, SW and Apte, SS. ADAMTS proteases generate active versican fragments that regulate interdigital web regression. Dev. Cell. Nov. 17; 17(5):687-698. 2009
  
  
• Matera, I, Watkins-Chow, DE, Loftus, SK, Hou, L, Incao, A, Silver, DL, Rivas, C, Elliott, EC, Baxter, LL, and Pavan, WJ.  A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet. July 15; 17(14):2118-2131. 2008
  
  
• Silver, DL, Hou, L, Somerville, R, Young, ME, Apte, SS, and Pavan, WJ. The secreted metalloprotease, ADAMTS20, is required for melanoblast survival. PloS Genetics. Feb. 29; 4(2):e1000003. 2008
  
  
• Silver, DL, Geisbrecht, ER, and Montell DJ. Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. Development. Aug; 132(15):3483-3492. 2005
  
  
• Silver, DL, Naora, H, Liu, J, Cheng, W, and Montell, D.J. Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Research. May 15; 64(10):3550-3558. 2004
  
  
• Silver, DL and Montell, DJ. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.  Cell. Dec 28; 107(7):831-841. 2001
  
  
• Tinker, B*, Silver, DL*, and Montell, DJ. Requirement for the vasa RNA Helicase in gurken mRNA Localization. Dev Biol. Jul 1; 1999(1):1-10. 1998                                
  *These authors contributed equally.
  
  
• Jenkins AL, Nannizzi-Alaimo L, Silver DL, Sellers JR, Ginsberg MH, Law DA, Phillips DR. Tyrosine phosphorylation of the b3 cytoplasmic domain mediates integrin-cytoskeletal interactions. J Biol Chem. May 29; 273(22):13878-13885. 1998
  
  
• Ford HL, Silver DL, Kachar B, Sellers JR, Zain SB. Effect of Mts1 on the structure and activity of nonmuscle myosin II.  Biochemistry. Dec 23; 36(51):16321-16327. 1997
  
  
• Silver DL, Vorotnikov AV, Watterson DM, Shirinsky VP, Sellers JR. Sites of interaction between kinase-related protein and smooth muscle myosin. J Biol Chem. Oct 3; 272(40):25353-25359. 1997

[Lab Website]