Representative Publications:

• Ray, C. A., Black, R. A., Kronheim, S. R., Greenstreet, T. A., Sleath, P. R., Salvesen, G. S. and D. J. Pickup (1992). Viral Inhibition of Inflammation: Cowpox virus encodes an inhibitor of the Interleukin-1b converting enzyme. Cell 69, 597-604.

• Hu, F.-Q., Smith, C. A., and Pickup, D. J. (1994). Cowpox virus contains two copies of an early gene encoding a soluble, secreted form of the Type II TNF receptor. Virology 204, 343-356.

• Smith, C. A., Hu, F.-Q., Davis-Smith, T, Richards, C.L., Smolak, P., Goodwin, R. G., and Pickup, D. J. (1996) Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LTa. Virology 223, 132-147.

• Loparev, V.N., Parsons, J.M., Knight, J.C., Fanelli Panus, J., Ray, C.A., Buller, R.M.L., Pickup, D.J., and Esposito, J.J. (1998). A third distinct tumor necrosis factor receptor of orthopoxviruses. Proc. Natl. Acad. Sci. USA 95, 3786-3791.

• Oie, K.L. and Pickup, D.J. (2001) Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of the activation of NF-kB. Virology 288: 175-187.

• Fanelli Panus, J., Smith, C.S., Ray, c.A., Davis Smith, T., Ptael, D.D., and Pickup, D.J. (2002).  Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue.  Proc. Natl. Acad. Sci. USA 99, 8348-8353.

• McKelvey, T.A., Andrews, S.A., Miller, S.E., Ray, C.A., and Pickup, D.J. (2002).  Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions. J. Virology 76: 11216-11225.